Naloxone

Question 1

Naloxone

Presentation

Answer 1

0.4mg (400mcg) in 1ml vial.

Question 2

Naloxone

Use

Answer 2

• Reversal of respiratory depression in a suspected narcotic overdose.

Question 3

Naloxone

Type

Answer 3

• Naloxone is a pure opioid antagonist .

Question 4

Naloxone

Dose

Answer 4

Dilute 0.4mg (400mcg) /1ml with 9mls NaCl for IV/IO administration
Adult:
• IM:
o 0.4mg (400mcg) every 5 minutes as needed up to 10mg
• IV/IO:
o Administer up to 400mcg Titrated to effect. Repeat every 2 minutes as clinically required to a maximum of 10mg.
Paediatric:
• IM:
o 0.4mg (400mcg) every 5-10 minutes as required up to 2mg.
• IV/IO:
o 0.01mg (10mcg)/kg initial dose. Subsequent dose 0.1mg (100mcg)/kg if required up to 2mg.
.

Question 5

Naloxone

Actions

Answer 5

.competitive inhibition at the opioid receptor sites. It prevents or reverses the effects of opioids, including respiratory depression, sedation and hypotension. In the absence of opioids it exhibits essentially no pharmacological activity.

Question 6

Naloxone

Contraindications

Answer 6

Nil

Question 7

Naloxone

Adverse effects

Answer 7

Withdrawal symptoms such as:
•	Aggression
•	Agitation
•	Nausea/vomiting
•	Dilated pupils and lacrimation
.

Question 8

Naloxone

Precautions

Answer 8

• Polypharmacy overdose.
• Naloxone half-life may be less than that of the opioid
.