Oncology-TKI Flashcards

Question 1

Q

Gleevec

Answer

A

Imatinib
Used in chronic myelogenous leukemia (CML)
BCR-ABL inhibitors

Question 2

Q

Sprycel

Answer

A

Dasatinib
Used in chronic myelogenous leukemia (CML)
BCR-ABL inhibitors

Question 3

Q

Tasigna

Answer

A

Nilotinib
Used in chronic myelogenous leukemia (CML)
BCR-ABL inhibitors

Question 4

Q

Iclusig

Answer

A

PONAtinib
Used in chronic myelogenous leukemia (CML)
BCR-ABL inhibitors

Question 5

Q

Bosulif

Answer

A

Bosutinib
Used in chronic myelogenous leukemia (CML)
BCR-ABL inhibitors

Question 6

Q

Zelboraf

Answer

A

Vemurafenib
Used in melanoma
BRAF inhibitors

Question 7

Q

Tafinlar

Answer

A

Dabrafenib
Used in melanoma
BRAF inhibitors

Question 8

Q

Mekinist

Answer

A

Trametinib
Used in melanoma
MEK inhibitor used in combination with BRAF inhibitor

Question 9

Q

Cotellic

Answer

A

Cobimetinib
Used in melanoma
MEK inhibitor used in combination with BRAF inhibitor

Question 10

Q

Gilotrif

Answer

A

Afatinib
Used in NSCLC (Non small cell lung cancer)
EGFR inhibitors

Question 11

Q

Tarceva

Answer

A

Erlotinib
Used in NSCLC (Non small cell lung cancer)
EGFR inhibitors

Question 12

Q

Iressa

Answer

A

Gefitinib
Used in NSCLC (Non small cell lung cancer)
EGFR inhibitors

Question 13

Q

Xalkori

Answer

A

Crizotinib

ALK inhibitors

Question 14

Q

Zykadia

Answer

A

Ceritinib

ALK inhibitors

Question 15

Q

Alecensa

Answer

A

Alectinib

ALK inhibitors

Question 16

Q

Tykerb

Answer

A

Lapatinib

HER2 inhibitors

Question 17

Q

Nerlynx

Answer

A

Neratinib

HER2 inhibitors

Question 18

Q

Nexavar

Answer

A

Sorafenib
Multiple target
Useful in cancers where traditional therapy has little benefits, such as hepatocellular, renal, thyroid cancers

Question 19

Q

Sutent

Answer

A

Sunitunib
Multiple target
Useful in cancers where traditional therapy has little benefits, such as hepatocellular, renal, thyroid cancers