Oncology LEK Flashcards
The treatment of pre-invasive cervical cancer consists in:
a. Excision of the affected part of the cervix
b. strict cytologic and colposcopy examination once a month
c. simple hysterectomy
d. radicalhysterectomy
e. Brachytherapy
a. Excision of the affected part of the cervix
Pre-invasive cervical cancer, often referred to as cervical intraepithelial neoplasia (CIN), is a precursor to invasive cervical cancer. This condition can be treated effectively by surgically excising the affected part of the cervix, typically through procedures like LEEP (loop electrosurgical excision procedure) or cold-knife conization.
Early gastric cancer is defined as:
a. malignant neoplasm crossing the gastric wall, with metastases to the
lymph nodes but with no metastases to the distant organs
b. Does not exceed the stomach wall
c. Malignant neoplasm of the stomach categorized as T2 by the TNM
classification
d. Malignantneoplasminmucousandsubmucousmembranes,butnot infiltrating the muscle membrane of the stomach
e. Malignant neoplasm of the stomach diagnosed in a patient under 50 years of age
d. Malignant neoplasm in mucous and submucous membranes, but not infiltrating the muscle membrane of the stomach
Early gastric cancer is a malignancy that is confined to the mucosa and submucosa, regardless of the presence or absence of lymph node metastasis. It has not yet infiltrated the muscularis propria or beyond.
Screeningprogramsarescientificallyjustifiedinpracticeforthedetectionof: 1) Breastcancer
2) prostatecancer 3) cervicalcancer 4) lungcancer
5) colorectalcancer 6) melanoma
The correct answer is:
a. 1,3,5
b. 1,2,3,5 c. 1,3,4,5 d. 1,2,3,4,5 e. 1,3,5,6
a. 1,3,5 (Breast cancer, cervical cancer, colorectal cancer)
Screening programs are justified for these cancers because early detection can significantly improve outcomes. Breast cancer screening typically involves mammography, cervical cancer screening involves Pap smears and HPV testing, and colorectal cancer screening can involve colonoscopy, stool tests, or other methods. Screening for other cancers like prostate and lung cancer may also be beneficial, but this can depend on factors like age, risk level, and individual patient circumstances.
An increased level of prostate-specific antigen (PSA):
a. Justifies the diagnosis of prostate carcinoma
b. indicated the need of transrectal ultrasound-guided fine-needle
biopsy
c. Indicates the need of transrectal ultrasound with excision for histologic examination
d. requirespelvicmagneticresonanceimaging
e. requires use of positron emission tomography
b. indicates the need of transrectal ultrasound-guided fine-needle biopsy
Elevated PSA levels may suggest the presence of prostate cancer or other conditions such as an enlarged or inflamed prostate. However, PSA is not definitive for diagnosing prostate cancer and further tests, like a transrectal ultrasound-guided fine-needle biopsy, are needed to confirm the diagnosis.
Fever in a patient with breast cancer who recently received a subsequent course of adjuvant postoperative chemotherapy:
a. May be due to treatment-induced neutropenia
b. is always an indication for the use of granulocyte-colony stimulating agents
c. is always an indication for the primary use of antifungal agents
d. AandBaretrue
e. A.b and C are true
May be due to treatment-induced neutropenia
Fever in patients who recently received chemotherapy could be a sign of febrile neutropenia, a condition characterized by low white blood cell counts and fever. This can indicate a severe infection that requires immediate medical attention.
In cancer patients with acute lysis syndrome laboratory abnormalities include:
a. uric acid
b. potassium
c. phosphates
d. correctanswersAandB
e. correct answers A,B,C
e. correct answers A,B,C (uric acid, potassium, phosphates)
Tumor lysis syndrome is a potentially life-threatening condition that can occur after treatment of cancer, particularly with rapidly proliferating malignancies. It is characterized by metabolic abnormalities including hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia.
Carcinoembryonic antigen level assessment is of most value in:
a. Breast cancer
b. Lung cancer
c. colorectal cancer
d. pancreaticcancer
e. stomach cancer
c. colorectal cancer
Carcinoembryonic antigen (CEA) is a type of tumor marker. It’s often used to monitor response to treatment and check for recurrence in people with colorectal cancer. It can also be used to a lesser extent in the management of other cancers, such as breast or lung cancer, but it is most valuable in colorectal cancer.
Which of the following was the most frequently occurring malignant tumor in Polish women for the 5 years (2010-2014)?
a. Breast cancer
b. Endometrial cancer
c. cervical cancer
d. ovariancancer
e. lung cancer
a. Breast cancer
As of my knowledge cut-off in 2021, breast cancer is the most common cancer in women worldwide and this has been the case in Poland during 2010-2014 as well. Note that statistics can change over time.
Symptoms of ovarian cancer do not include:
a. pain in the lower abdomen or pelvis
b. oliguria
c. increase in the abdominal circumference
d. Tympanites,abdominaldistention
e. urge incontinence
b. oliguria
Early gastric cancer is characterized by its restriction to the mucosa and submucosa, irrespective of the presence or absence of lymph node metastasis. It is defined as such since it has not yet invaded the muscle membrane or deeper layers of the stomach wall. The other options listed describe more advanced stages of gastric cancer or aren’t related to the staging of gastric cancer.
Which of the following must be performed first in the case of a patient with a liver tumor diagnosed incidentally on ultrasound and a suspicion of cancer metastasis?
a. Accurate medical history, contrast enhanced CT of the abdomen, endoscopy of the upper and lower gastrointestinal tract
b. Accurate medical history and core needle biopsy of the tumor for histopathological examination
c. Accurate medical history and PET-CT as soon as possible
d. Accuratemedicalhistory,contrastenhancedCToftheabdomenand
urgent decision on laparotomy and partial hepatectomy with tumor
resection
e. All the above statements are false
a. Accurate medical history, contrast enhanced CT of the abdomen, endoscopy of the upper and lower gastrointestinal tract
In which of the following breast areas breast cancer most frequently resides?
a. Retroareolar
b. upper inner quadrant
c. lower outer quadrant
d. lowerinnerquadrant
e. upper outer quadrant
e. upper outer quadrant
Cancers of unknown origin:
1) represent 3-10% of all malignant tumors;
2) do not require detailed diagnostics, because the primary site may be identified in 5% of cases only
3) are most frequently adenocarcinomas;
4) are more frequent in women
5) are indications for positron emission tomography.
The correct answer is:
a. 1,2 b. 1,3 c. 1,3,5 d. 2,3,4 e. 2,4
c. 1,3,5
Pancreatic cancer may be related to:
a. Obesity
b. smoking tobacco
c. diabetes
d. correctanswer:AandB
e. correct answer: A,B and C
e. correct answer: A,B and C
The typical management of acute tumor lysis syndrome includes:
a. Hydration and forced diuresis
b. allopurinol administration
c. Glucocorticoids administration
d. A and B
e. A, B, C
d. A and B
Cancer-related ileus:
a. Is most frequent in patients with ovarian cancer and gastrointestinal tumors
b. May be caused by a mechanical obstruction or may be related to metabolic
disorder
c. Is always an indication for using somatostatin analogues
d. A and B are true
e. A, B and C are true
d. A and B are true
Cancer staging:
a. is important to determine the prognosis for patients
b. helps to select the best method of treatment
c. is based on TNM classification for all malignant tumors
d. A and B are true
e. A, B and C are true
d. A and B are true
Which of the following is the most common cause of death due to neoplastic disease in women in Poland?
a. Lung cancer
b. Breast cancer
c. cervical cancer
d. ovariancancer
e. colon cancer
a. Lung cancer
Bronchoscopy in a patient with a suspicion of lung cancer: 1) is one of the basic diagnostic examinations; 2) should be applied to peripheral lesions only; 3) may include tissue sampling for histologic examination; 4) provides cellular material sampling for cytological examination; 5) may be performed only in patients with the normal values of respiratory function tests. The correct answer is:
a. 1,2
b. 1,3,4
c. 2,4,5
d. 1,2,5
e. All the answers are correct
b. 1,3,4
- A 72-year-old woman in the 4th stage of chronic kidney disease and with
severe back pain was admitted to the department of nephrology with the suspicion
of monoclonal immunoglobulin deposition disease in the course of multiple
myeloma. Indicate the examinations that allow to confirm the diagnosis:
1) presence of plasmocytes in the bone marrow > 10%;
2) nephrotic proteinuria;
3) presence of monoclonal immunoglobulins in the serum and in the urine;
4) haematuria;
5) deposits of light or heavy immunoglobulin chains in the kidney glomeruli.
The correct answer is:
a. 1,2,5 b. 1,2,4 c. 1,3,5 d. 1,3,4 e. 2,4,5
c. 1,3,5
Which of the following is not a risk factor for endometrial cancer?
a. Obesity
b. smoking tobacco
c. Diabetes
d. exogenous estradiol
e. late menopause
b. smoking tobacco
Which of the following is not typical of cervical cancer?
a. Urinary urgency
b. Bloody vaginal discharge with unpleasant smell
c. intermenstrual bleeding
d. abdominalpain
e. contact bleeding
a. Urinary urgency
The most frequent origin of metastasis in the liver is:
a. prostate cancer
b. colon cancer
c. kidney cancer
d. thyroid cancer
e. parathyroid carcinoma
b. colon cancer
Indicate the true sentences regarding screening for the neoplastic disorders of female genital organs:
1) screening for vaginal and vulvar cancer is not performed because of the low incidence of these tumours;
2) screening for endometrial cancer is not performer because its first symptoms, i.e. uterine bleeding, are easily noticed by women and reported to their doctors;
3) screening for non-epithelial tumours of the ovaries, the uterus and the vagina is not performed because of the low incidence of these tumours;
4) screening for endometrial cancer is performed and includes ultrasound imaging, the measurement of the markers: CA 125, HE 4 (human epididymis protein 4) and chorion gonadotropin;
5) Screening for cervical cancer is performed and includes a cytological test, a test which sensitivity reaches 85-90% in leading centers.
The correct answer is:
a. 1,2,3
b. 1,5
c. 3,4,5
d. 4,5
e. 1,3,4
a. 1,2,3
Which of the following concerning carcinoma of the ampulla of Vater is false?
a. predominant sign of carcinoma of the ampulla of Vater is painless mechanical
jaundice
b. carcinoma of the ampulla of Vater may lead to so called courvoisier’s sign
c. Percentage of resection operation in carcinoma of the ampulla of Vater is
significantly lower in pancreatic head cancer
d. long term results of treatment are better in carcinoma of the ampulla of Vater
than in pancreatic cancer
e. its incidence in males and females is similar
c. Percentage of resection operation in carcinoma of the ampulla of Vater is
significantly lower in pancreatic head cancer
Which of the following concerning pancreatic cancer is false?
a. More than 95% of cases of pancreatic cancer is ductal cancer,
b. usually located in the body of pancreas Mechanical jaundice may be the first sign of pancreatic cancer
c. About 15-30% of pancreatic cancers are resectable at diagnosis
d. Primary surgical techniques used in the treatment of cancer of the body of the pancreas is partial pancreatic resection
e. TNM classification is the most commonly used method for the evaluation of tumor staging
b. usually located in the body of pancreas Mechanical jaundice may be the first sign of pancreatic cancer
Which of the following is relative contraindication to conservative surgery in breast cancer?
a. Tumor diameter exceeding 3cm
b. lack of patients consent to conservative surgery
c. synchronous bilateral breast cancer
d. contraindications to radiotherapy
e. Breast cancer in males
c. synchronous bilateral breast cancer
The most common neuroendocrine pancreatic tumor is:
a. Gastrinoma
b. Somatostatinoma
c. VIPoma
d. Glucagonoma
e. Insulinoma
e. Insulinoma
In the TNM classification of colon cancer T1 denotes infiltration of:
a. Mucous membrane
b. Submucous membrane
c. muscle membrane
d. serous membrane
e. neighboring organs
b. Submucous membrane
A 47-year-old woman comes to the office because of a weight gain of 10 kg
during the last 6 weeks. She is hungry all the time. Sometimes she does not
remember what happened a few minutes before. What is the most probable
diagnosis that has to be excluded first?
a. Insulinoma
b. reactive hypoglycemia
c. Type 2 Diabetes
d. Type 1 Diabetes
e. Adrenal Insufficiency
a. Insulinoma
Which of the following does not influence (neither positively or negatively) the
risk of colon cancer?
a. Tobacco smoking
b. Age >50 years
c. Aspirin
d. Obesity
e. Angiotensin convertase inhibitors or angiotensin receptor antagonists
e. Angiotensin convertase inhibitors or angiotensin receptor antagonists
Wells’ scoring system used to estimate the risk of pulmonary embolism does
not include:
a. Blood platelet count
b. Tachycardia >100/min
c. Hemoptysis
d. Malignant tumor
e. recent surgery
a. Blood platelet count
Which of the following colon lesions bears the highest risk of malignant
transformation?
a. Tubulovillous adenoma
b. tubular adenoma
c. villous adenoma
d. hyperplastic poly
e. juvenile polyp
c. villous adenoma
Indicate the true statements concerning esophageal cancer:
1) it has a good prognosis;
2) most common type of esophageal cancer is adenocarcinoma;
3) achalasia is one of its risk features;
4) it infiltrates surrounding tissues at early stages and metastases to the lymph
nodes;
5) surgery is the primary mode of treatment.
The correct answer is:
a. 1,2,3,5
b. 1,2,3
c. 1,2,5
d. 3,4
е. 3,4,5
e. 3,4,5
“This tumor can develop before puberty but the peak incidence is observed in
women of reproductive age. It easily ruptures which may lead to peritoneal signs
and symptoms demanding urgent surgery. In postmenopausal women it may cause
abnormal bleeding from the reproductive tract. Surgical excision does not guarantee
full recovery as this tumor recurrence may be observed as many as 30 ears after
the initial diagnosis”.
The above is a characteristic of:
a. Ovarian cancer
b. sarcoma
c. Hydatidiform mole
d. Germinoma
e. Granulosa cell tumor
e. Granulosa cell tumor
Indicate the true statement concerning ovarian cancer surgery:
a. it strives for tumor sample obtaining and fast radical chemotherapy
application
b. cytoreduction is performed to the highest possible extent
c. only and always the affected ovary is removed
d. following ureterectomy the region of the lesser pelvis may be irradiated
e. neoadjuvant chemotherapy is always used in order to decrease a tumor mass
b. cytoreduction is performed to the highest possible extent
When should the next cytological examination be ordered in a 35-year-old
multipara with normal results of the last three cytological examinations and
without any risk factors?
a. in 3 months
b. in 6 months
c. in a year
d. in three years
e. only of some symptoms occur, such as increased vaginal discharge or contact
bleeding
d. in three years
A 45-year-old woman with the diagnosis of cervical cancer went to see her
gynecologist. Which of the following data from her medical history is not a risk
factor for this cancer?
a. 5 deliveries
b. numerous viral and bacterial infections of the cervix
c. obesity
d. smoking
e. frequent changing of sexual partners
c. obesity
Which of the following are the main symptoms of Hodgkin’s lymphoma in
children
a. Abdominal pain, bleeding, vomiting, dysphaga
b. non-symmetrical lymphadenopathy, affecting mainly cervical and
supraclavicular nodes (firm and painless, forming packets), fever
c. Abdominal pain, bone pain, hepatosplenomegaly, normal lymph nodes
d. Apathy, thrombocytopenic purpura, subfebrile state, predilection for
infections
e. high fever, lesions on the mucosa of the pharynx, Lymphadenopathy,
hepatosplenomegaly
b. non-symmetrical lymphadenopathy, affecting mainly cervical and
supraclavicular nodes (firm and painless, forming packets), fever
Alpha-fetoprotein is a laboratory indicator of:
a. Gastrointestinal stromal tumor (GIST)
b. fetal renal cancer
c. Gastric sarcoma
d. Hepatocellular carcinoma
e. pancreatic islet tumor
d. Hepatocellular carcinoma
Extranodal lymphoma is most commonly localized in:
a. stomach
b. duodenum
c. small intestine
d. colon
e. rectum
a. stomach
Which of the following operations can be performed in the case of
adenocarcinoma localized in the sigmoid colon?
a. Laparoscopic sigmoid resection
b. Hartmann’s procedure by means of laparotomy
c. Sigmoid resection by means of laparotomy
d. Laparoscopic Hartmann operation
e. All of the above
e. All of the above
The most common symptom reported by patients with vulvar cancer:
a. pain
b. fever
c. malaise
d. pruritus
e. Dysuria
d. pruritus
Which of the following is the most probable diagnosis in the case of impaired
fertility, chronic pelvic pain, painful periods, and dyspareunia?
a. Endometriosis
b. Ovarian cancer
c. cervical cancer
d. Adnexitis
e. premature ovarian failure
a. Endometriosis
Microscopic evaluation of the material obtained at the outer opening of the
cervix is called cervical smear (Papanicolaou test) and is used to diagnose
precancerous states or cervical cancer. Which of the following should be advised in
the case of the abnormal result of cervical smear - HSIL (high-grade squamous
intraepithelial lesion)?
a. Repeat cervical smear- twice every 4-6 months
b. perform colposcopy with the biopsy of the suspected lesion and abrasion
of the cervical canal
c. HPV determination
d. repeat cervical smear and determine HPV
e. none of the above
b. perform colposcopy with the biopsy of the suspected lesion and abrasion
of the cervical canal
The risk factor for breast cancer is not:
a. Age over 35
b. regular consumption of alcohol
c. obesity
d. late menarche and early menopause
e. use of hormone replacement therapy including oral contraceptives
d. late menarche and early menopause
Which of the following does not suggest the development of malignant
melanoma from a nevus?
a. enlargement of the nevus
b. bleeding nevus
c. equal distribution of pigment in the nevus
d. inflammation in the nevus
e. ulceration within the nevus
c. equal distribution of pigment in the nevus
The Lauren classification concerns:
a. colon cancer
b. stomach cancer
c. pancreatic cancer
d. liver cancer
e. extension of gastric inflammatory changes
b. stomach cancer
The increased risk of endometrial cancer has not been associated with:
a. obesity
b. diabetes
c. hypertension
d. late menopause
e. endometriosis
e. endometriosis
Which of the following is characteristic of borderline ovarian tumors?
a. no destructive infiltration of the stroma
b. occurrence limited to the ovaries only
c. prognosis similar to that of ovarian cancer
d. no effective treatment options available
e. occurrence in postmenopausal women only
a. no destructive infiltration of the stroma
Indicate the true statements concerning vulvar cancer:
1) most commonly it develops from the stratified squamous epithelium;
2) HPV infections play an important role in pathogenesis of some vulvar cancers;
3) supraclavicular lymph nodes are the most common site of metastasis;
4) basic treatment consists in the surgery and radiochemotherapy;
5) hormonal therapy is the most effective method of vulvar cancer treatment.
The correct answer is:
a. only 5
b. 1.2.3
c. 1.2.5
d. 2,3,4
e. 1,2,4
e. 1,2,4
What kind of damage to the kidneys can be observed in the course of multiple
myeloma?
1) AL. amyloidosis;
2) focal segmental glomerulosclerosis (FSGS);
3) monoclonal immunoglobulin deposition disease;
4) cast nephropathy;
5) membranous nephropathy.
The correct answer is:
а. 1,3,5
b. 1,3,4
c. 1,2,3,5
d. 2,4,5
е. 3,4
b. 1,3,4
Ménétrier’s disease belongs to precancerous condition of:
a. stomach
b. duodenum
c. small intestine
d. large intestine
e. gallbladder
a. stomach
Early gastric cancer is defined as:
a. lesion limited only to the epithelium only
b. lesion limited only to the mucous membrane without metastases in the
lymph node
c. lesion limited only to the mucous membrane irrespective of the presence of
metastases in the lymph nodes
d. lesion limited to the mucous membrane and submucosa, regardless of the
presence of metastases in the lymph nodes.
lesion limited to the mucous membrane and submucosa without the
presence of metastases in the lymph nodes
d. lesion limited to the mucous membrane and submucosa, regardless of the
presence of metastases in the lymph nodes.
Which of the following is the most common source of metastases to the liver?
a. colon cancer
b. pancreatic cancer
c. gallbladder cancer
d. gastric cancer
e. lung cancer
a. colon cancer