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Final NAPLEX > Oncology drugs > Flashcards

Oncology drugs Flashcards

1
Q

Filgrastim

A

Neuopgen, Zarxio

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2
Q

Pegfilgrastim

A

Neulasta

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3
Q

Aprepitant

A

Emend

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4
Q

Fosaprepitant

A

Emend (injection only), dosed one time

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5
Q

Ondansetron

A

Zofran

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6
Q

Granisetron

A

Sancuso

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7
Q

Dolasetron

A

Anzemet

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8
Q

Palonosetron

A

Aloxi

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9
Q

Palonosetron + netupitant

A

Akynzeo

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10
Q

Dexamethasone

A

Decadron

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11
Q

Prochlorperazine

A

Compazine

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12
Q

Promethazine

A

Phenergan

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13
Q

Metoclopramide

A

Reglan

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14
Q

Dronabinol

A

Marinol

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15
Q

Nabilone

A

Cesamet

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16
Q

Mucsal Barrier Gel Spray

A

Episil, Gelclair

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17
Q

Artificial Saliva Substitutes

A

Aquora, Biotene

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18
Q

Pilocarpine

A

Salagen

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19
Q

Calcitonin

A

Miacalcin

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20
Q

Zoledronic acid

A

Zometa

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21
Q

Denosumab

A

Xgeva

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22
Q

Tamoxifen

A

Soltamox (SERM)

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23
Q

Fulvestrant

A

Faslodex (SERM)

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24
Q

Anastrozole

A

Arimidex (Aromatase inhibitor)

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25
Q

Letrozole

A

Femara (Aromatase inhibitor)

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26
Q

Exemestane

A

Aromasin (Aromatase inhibitor)

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27
Q

Leuprolide

A

Lupron Depot (GnRH agonist)… osteoporosis + tumor flare

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28
Q

Goserelin

A

Zoladex (GnRH agonist)… osteoporosis + tumor flare

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29
Q

Degarelix

A

Firmagon Gonadotropic releasing hormone antagonist

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30
Q

Bicalutamide

A

Casodex (First generation antiandrogen)

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31
Q

Enzalutamide

A

Xtandii (Second generation antiandrogens)

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32
Q

Cyclophosphamide

A

Cytoxan (alkylating agent)

33
Q

Carmustine

A

BiCNU (alklylating agent)

34
Q

Bendamustine

A

Bendeka (alkylating agent)

35
Q

Busulfan

A

Myleran (alkylating agent)

36
Q

Melphalan

A

Alkeran (alkylating agent)

37
Q

Cisplatin

A

nephrotoxic, ototoxic (confirm doses >100 mg/m2/cycle with prescriber)

38
Q

Carboplatin

A

Calvert formula: dose = (target AUC) x (GFR + 25) [AUC range from 2-8 mg/ml*min) (GFR commonly capped at 125 ml/min)

39
Q

Oxaliplatin

A

acute sensory neuropathy, cold

40
Q

Doxorubicin

A

Adriamycin (Anthracycline, total cumulative dose 450-550 mg/m2)

41
Q

Dexrazoxane

A

Totect, used for anthracycline extravasation; Zinecard for cardioprotection

42
Q

Mitoxantrone

A

anthracenedione related to anthracyclines; blue urine discoloration

43
Q

Vincristine

A

Vincasar (vinca alkaloid), intrathecal = death

44
Q

Vinblastine

A

myelosuppressive, less neurotoxic

45
Q

Paclitaxel

A

Taxol (Taxane) (peripheral sensory neuropathy)

46
Q

Docetaxel

A

Taxotere (Taxane)

47
Q

Cabazitaxel

A

Jevtana (Taxane)

48
Q

Paclitaxel albumin-bound

A

Abraxane (no premedication required)

49
Q

Irinotecan

A

Camptosar (topoisomerate I inhibitor (acute cholinergic symptoms, delayed diarrhea)

50
Q

Etoposide

A

VePesid (Topoisomerase II inhibitor)

51
Q

Fluorouracil

A

Adrucil, 5-FU (Pyrimidine analog antimetabolites)

52
Q

Capecitabine

A

Xeloda (Oral prodrug of fluorouracil)

53
Q

Methotrexate

A

Trexall [folate antimetabolite] (drug interaction with NSAIDs, csalicylates, beta-lactams, PPI, sulfanoamide antibiotics –> decrease clearance of methotrexate)

54
Q

Pemetrexed

A

Alimta (folate antimetabolite, related to methotrexate)

55
Q

Tretinoin

A

All-trans retinoic acid (used in acute promyelocytic leukemia), decreases proliferation and increases differentiation

56
Q

Arsenic trioxide

A

Trisenox (QT prolongation)

57
Q

Asparaginase

A

Erwinaze, deprives leukemia cells of essential amino acid asparagine

58
Q

Pegaspargase

A

Oncaspar (pegylated form of asparaginase allows less frequent dosing and less allergic reactions)

59
Q

Bleomycin

A

Not myelosuppressive, lifetime dose of 400 units due to pulmonary toxicity

60
Q

Mitomycin

A

Vesicant, antidote is dimethyl sulfoxide (cool compress)

61
Q

Everolimus

A

Afinitor - for cancer

Zortress - for transplant

62
Q

Lenalidomide

A

Revlimid (immunomodulator used in multiple myeloma, severe birth defects)

63
Q

Pamilidomide

A

Pomalyst (immunomodulator used in multiple myeloma. severe birth defects.)

64
Q

Thalidomide

A

Thalomid (immunomodulator used in multiple myeloma. severe birth defects)

65
Q

Bortezomib

A

Velcade (proteasome inhibitor - antiviral can prevent herpes reactivation)

66
Q

Carfilzomib

A

Kyprolis (peripheral neuropathy)

67
Q

Bevacizumab

A

Avastin (VEGF innibitor), delayed wound healing

68
Q

Ramucirumab

A

Cyramza (VEGF inhibitor) delayed wound healing

69
Q

Trastuzumab

A

Herceptin (Human epidermal growth factor receptor 2 HER2 inhibitors), cardiotoxicity, embryo-fetal toxicity

70
Q

Pertuzumab

A

Perjeta (Human epidermal growth factor receptor 2 HER2 inhibitors), cardiotoxicity, embryo-fetal toxicity

71
Q

Ado-trastuzumab Emtansine

A

Kadcycla (Human epidermal growth factor receptor 2 HER2 inhibitors), cardiotoxicity, embryo-fetal toxicity

72
Q

Cetuximab

A

Erbitux (Epidermal Growth Factor Receptor EGFR inhibitor), cardiac arrest; rash + sun sensitivity

73
Q

Panitumumab

A

Vectibix (EGFR inhibitor) dermatologic toxicities

74
Q

Rituximab

A

Rituxan (Leukocyte Cluster of Differentiation (CD) Antigen Inhibitors , Rituxmab is CD20; premedicate for infusion reactions; must be CD20 positive to use

75
Q

Blinatumomab

A

Blincyto (Leukocyte Cluster of Differentiation CD19 and CD3 inhibitor)

76
Q

Pembrolizumab

A

Keytruda (PD-1 inhibitor -> blocks the binding of the Programmed cell death ligand from binding PD-1 receptor on T cells, which allows T-cells to live longer and attack cancer)

77
Q

Nivolumab

A

Opdivo (PD-1 inhibitor)

78
Q

Ipilimumab

A

Yervoy (Cytotoxic T-Lymphocyte Antigen-4 CTLA-4 inhibitor)

79
Q

Common Toxicities of Tyrosine Kinase Inhibitors (Hint: thyroid, heart, skin, blood vessels, intestines, liver)

A
  1. Thyroid gland: Hypothyroidism
  2. Heart: QT Prolongation
  3. Skin: EGFR TKI cause severe acienform rash that is correlated with efficacy
  4. TKI that target vascular endothelial growth factor: Hand-foot syndrome and hypertension (interference with growth of blood vessels)
  5. large intestine: diarrhea
  6. liver: hepatic metabolite (CYP3A4 substrate); hepatic toxicity

Final NAPLEX (15 decks)

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