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Final NAPLEX > HIV > Flashcards

HIV Flashcards

1
Q

List seven HIV drug classes

A
  1. Nucleoside/Nucleotide reverse Transcriptase Inhibitors (NRTI)
  2. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)
  3. Protease Inhibitors/PK Boosters
  4. Integrase Strand Transfer Inhibitors (INSTI)
  5. CCR5 Antagonists
  6. Fusion Inhibitors
  7. CD4-Directed Post-Attachment HIV-1 Inhibitor
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2
Q

List 8 NRTI used in HIV

A
  1. Ziagen (abacavir)
  2. Epivir (Lamivudine)
  3. Emtriva (emtricitabine)
  4. Viread (tenofovir disoproxil fumarate)
  5. TAF (tenofovir alafenamide)
  6. Retrovir (Zidovudine)
  7. Zerit (Stavudine)
  8. Videx (Didanosine)
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3
Q

List four NNRTI used in HIV

A
  1. Sustiva (Efavirenz)
  2. Edurant (Rilpivirine)
  3. Viramune, Viramune XR (Nevirapine)
  4. Intelence (Etravirine)
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4
Q

List eight protease inhibitors used in HIV

A
  1. Prezista (Darunavir)
  2. Reyataz (Atazanavir)
  3. Lexiva (Fosamprenavir)
  4. Crixivan (Indinavir)
  5. Kaletra (Lopinafivr + ritonavir)
  6. Viracept (Nelfinavir)
  7. Invirase (Saquinavir)
  8. Aptivus (Tipranavir)
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5
Q

List two pharmacokinetic boosters used in HIV

A
  1. Norvir (Ritonavir)

2. Cobicistat (Tybost)

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6
Q

List four INSTIs used in HIV

A
  1. Elvitegravir
  2. Bictegravir (contained in Biktarvy)
  3. Tivicay (Dolutegravir)
  4. Isentress (Raltegravir)
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7
Q

List 1 CCR5 antagonist used in HIV

A
  1. Selzentry (Maraviroc)
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8
Q

List 1 fusion inhibitor used in HIV

A
  1. Fuzeon (Enfuvirtide)
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9
Q

List 1 CD-4 directed post-attachment HIV-1 inhibitor

A
  1. Trogarzo (Ibalizumab-uiyk)
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10
Q

List 1 PI-based single tablet regimen

A
  1. Symtuza (Darunavir + Cobicistat + emtricitabine + tenofovir alafenamide)
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11
Q

List five NNRTI-based single tablet regimens

A
  1. Atripla (Efavirenz + emtricitabine + tenofovir disoproxil fumarate)
  2. Symfi (Efavirenz 600 mg+ lamivudine + TDF)
  3. Symfi lo (Efavirenz 400 mg + lamivudine + TDF)
  4. Complera (Rilpivirine + emtricitabine + TDF)
  5. Odefsey (Rilpivirine + emtricitabine + tenofovir alafenamide)
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12
Q

List five INSTI-based single tablet regimens

A
  1. Stribild (elvitegravir + cobicistat + emtricitabine + TDF)
  2. Genvoya (elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide)
  3. Biktary (Bictegravir + emtricitabine + tenofovir alafenamide)
  4. Triumeq (Dolutegravir + abacavir + lamivudine)
  5. Juluca (Dolutegravir + rilpivirine)
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13
Q

What is contained in Epzicom?

A

abacavir + lamivudine

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14
Q

what is contained in Truvada?

A

emtricitabine + TDF

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15
Q

With or without food: Atazanavir and Evotaz

A

With (PI)

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16
Q

With or without food: darunavir and prezcobix

A

with (PI)

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17
Q

With or without food: Atripla

A

without

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18
Q

With or without food: Efavirenz

A

without

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19
Q

With or without food: Indinavir (boosted)

A

with (PI)

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20
Q

With or without food: Kaletra oral solution

A

with (contains ritonavir)

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21
Q

With or without food: Symfi

A

without

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22
Q

With or without food: nelfinavir

A

with (PI)

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23
Q

With or without food: ritonavir

A

with (PI)

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24
Q

With or without food: symfi lo

A

without

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25
Q

With or without food: saquinavir

A

with (PI)

26
Q

With or without food: tipranavir

A

with (PI)

27
Q

With or without food: Genvoya

A

with (package insert)

28
Q

With or without food: Complera

A

with (because of rilpivirine)

29
Q

With or without food: Juluca

A

with (because of rilpivirine)

30
Q

With or without food: Odefsey

A

with (because of rilpivirine)

31
Q

With or without food: Stribild

A

with

32
Q

With or without food: Symtuza

A

with (because of darunavir)

33
Q

With or without food: Indinavir (unboosted)

A

without

34
Q

With or without food: didanosine

A

without

35
Q

List 22 HIV medications that must be dispensed in original container

A
  1. Atripla
  2. Biktarvy
  3. Cimduo
  4. Complera
  5. Descovy
  6. Genvoya
  7. Juluca
  8. Odefsey
  9. Stribild
  10. Symfi and Symfi Lo
  11. Symtuza
  12. Triumeq
  13. Truvada
  14. Darunavir
  15. Dolutegravir
  16. Etravirine
  17. Indinavir
  18. Nelfinavir
  19. Raltegravir
  20. Ritonavir
  21. Rilpivirine
  22. Tenofovir disoproxil fumarate
36
Q

NRTI class effect?

A

Lactic acidosis

37
Q

NNRTI class effect?

A

rash

38
Q

PI class effect?

A

metabolic abnormalities (hyperlipidemia, hyperglycemia, lipohypertrophy) and N/V/D

39
Q

Common ADR of abacavir?

A

Hypersensitivity and possible increase risk of MI

40
Q

Common ADR of didanosine?

A

Pancreatitis and peripheral neuropathy

41
Q

Common ADR of emtricitabine

A

Headache

42
Q

Common ADR of lamivudine?

A

Headache

43
Q

Common ADR of stavudine?

A

Pancreatitis and peripheral neuropathy

44
Q

Common ADR of Tenofovir (TDF and TAF)

A

Renal toxicity (fanconi syndrome) and decreased bone mineral density

45
Q

Common ADR of Zidovudine?

A

Macrocytic anemia and myopathy

46
Q

Common ADR of Efavirenz?

A

CNS effects (impaired concentration, abnormal dreams, confusion)

47
Q

Common ADR of Nevirapine?

A

Hepatotoxicity and hypersensitivity

48
Q

Common ADR of Etravirine?

A

SJS/TEN

49
Q

Common ADR of Rilpivirine?

A

Depression and Insomnia

50
Q

Common ADR of darunavir?

A

Headache

51
Q

Common ADR of atazanavir?

A

Nephrolithiasis and indirect hyperbilirubinemia

52
Q

Common ADR of fosamprenavir?

A

rash

53
Q

Common ADR of indinavir?

A

Nephrolithiasis and urolithiasis

54
Q

Common ADR of lopinavir/ritonavir?

A

hypertriglyceridemia

55
Q

Common ADR of nelfinavir?

A

Diarrhea

56
Q

Common ADR of ritonavir?

A

N/V/D

57
Q

Common ADR of saquinavir?

A

Nausea

58
Q

Common ADR of Tipranavir?

A

Intracranial hemorrhage

59
Q

Common ADR of Raltegravir?

A

Increased CPK, myopathy and rhabdo

60
Q

Common ADR of Elvitegravir?

A

Headache and insomnia

61
Q

Common ADR of dolutegravir?

A

Increased SCr without effecting GFR

Final NAPLEX (15 decks)

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