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Mrcp > Oncology > Flashcards

Oncology Flashcards

1
Q

Carcinogen that causes hepatocellular carcinoma

A

Aflatoxin

AFLatoxin gives you A F*cked Liver (HCC)’

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2
Q

Carcinogen that causes gastric and oesophageal cancer

A

Nitrosamine

  • ‘Nitrosamines are not NIce to swallow (GI)’
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3
Q

Carcinogen that causes transitional cell carcinoma of bladder

A

Aniline dye

  • ‘ANnihilates your bladder’
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4
Q

Carcinogen that causes lung malig or liver angiosarcoma

A

Arsnic and Vinyl chloride

  • ‘Hip Angie (Hepatic Angiosarcoma) put on a VINYL and shook her ARSE
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5
Q

Carcinogen that causes leukaemia

A

Benzene

Ben and Luke..

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6
Q

What gene defect causes Li-Fraumeni

A

p53

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7
Q

What is the inheritance of Li-Fraumeni

A

Autosomal dominant

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8
Q

Malignancies associated with EBV

A

Burkitt’s lymphoma
Hodgkin’s lymphoma
Nasopharyngeal carcinoma
Hiv CNS lymphoma

Hairy leukoplakia (mon malig)

Note EBV is part of herpes family

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9
Q

Malignancies of Li-Fraumeni syndrome

A

Soft tissue sarcomas, breast cancer, glioblastoma, lymphoma, leukaemia

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10
Q

tumour marker for seminoma

A

hCG is associated with testicular seminomas

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11
Q

tumour marker for schwannomas

A

s-100

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12
Q

Antibody associated with breast colorectal and SCLC rich gives diffuse hypertonia or stiff persons syndrome

A

Anti GAD

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13
Q

Antibody associated with ovarian and breast cancer that causes cerebellar syndrome paraneoplastic

A

Anti yo

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14
Q

Best prognosis in Hodgkin’s lymphoma….

A

Hodgkin’s lymphoma - best prognosis = lymphocyte predominant

Worst is lymphocyte depleted

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15
Q

Diagnosis for patient presenting with haematuria, loin pain, abdominal mass.. on examination you find a eft varicocele

A

Renal cell carcinoma… Can have cannonball mets and cause progressive dyspnoea in about 10%

Varococele from occlusion of left testicular vein

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16
Q

Cancer diagnosis with long history of cough/haemoptysis, cherry red ball seen on bronchoscopy

A

Carcinoid cancer. NOT related to smoking and difficult to see on CXR

17
Q

good v bad prognostics for ALL

A 
Good - Bad
L1 - L3
Low WBC - High Wbc
Undiff - B or T differrentiation
hyperdiploidy - HYPO diploidy
t1:19/11:21 - T9:22
Female - Male
2-10yr  - <2 or >10
18
Q

Tumour marker for peritoneal cancer

A

Ca125

…as well as ovarian cancer and can be used to monitor response to chemo

19
Q

What is Waldenstrom’s macroglobulinaemia?

A

Uncommon condition, seen in older men.
Lymphoplasmacytoid malignancy which secretes monoclonal IgM paraprotein

Weight loss, lethargy, hyperviscosity (e.g. visual disturbances), hepatosplenomegaly, lymphadenopathy

20
Q

Classic presentation of Waldenstrom’s macroglobulinaemia?

A 
Older man , lethargy weight loss
Visual disturbances (or other hyperviscosity symps)

Hepatosplenomegaly
Lymphadenopathy

21
Q

What blood results would you expect in Tumour lysis syndrome?

A

high potassium
high phosphate
High urate
LOW calcium..

. Due to breakdown of cells and release of cellular content

22
Q

What cancer is Lambert Eaton seen in

A

Lambert-Eaton syndrome occurs almost exclusively in small cell lung cancer… to a lesser extent breast and ovarian cancer

23
Q

Palliative patient in pain with CKD, not controlled on cocodamol

A

Alfentanil, buprenorphine and fentanyl are preferred opioids in CKD

24
Q

Oral morphine to SC morphine

A

/2

25
Q

Oral morphine to SC diamorphine

A

/3

26
Q

Oral oxycodone to SC diamorphine

A

/1.5

27
Q

PO codeine to morphine

A

/10

28
Q

oral morphine to transdermal fentanyl

A

1:100

fentanyl 100 patch will deliver 2400 micrograms or 2.4 mg of fentanyl per 24 hours

29
Q

Tumour marker for seminoma

A

hCG

30
Q

neuroblastoma tumour marker

A

Bombesin

31
Q

Teratoma tumour marker

A

AFP

Mrcp (21 decks)

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