oncology Flashcards
what is neuroblastoma
tumours arising from neural crest tissue whcih develops into the nervous system and adrenal glands
at what age does neuroblastoma occur
often occurs in children under 5yrs
clinical presentation of neuroblastoma
bone pain
weight loss
malaise
abdo mass
hepatomegaly
limp
where does neuroblastoma often start
abdomen
which can then spread to bones liver and skin
investigations for neuroblastoma
blood tests
imaging
urinalysis - catecholamines
what is retinoblastoma
malignant tumour of retinal cells which can affect one or both eyes
clinical features of retinoblastoma
white pupillary reflex instead of normal corneal reflex
squint/ strabismus
redness or inflammation of eye
poor vision
which chromosome is the retinoblastoma susceptibility gene found in
chromosome 13
pattern of inheritance in retinoblastoma
dominant with incomplete penetrance
inheritance of bilateral and unilateral retinoblastoma
all bilateral tumours are hereditary
most unilateral tumours are not
investigations of retinoblastoma
corneal reflex test
what is wilms tumour
renal tumour
most present before 5yrs
clinical features of wilms tumour
large abdo mass
haematuria
lethargy
fever
htn
weight loss
investigations for wilms tumour
USS- first line
biopsy- gold
management of wilms tumour
chemo then nephrectomy
radio is for those with more advanced disease
