Oncology

Question 1

Describe the cell cycle

Answer 1

G0 - resting
[Interphase]
G1 - Growth phase, protein synthesis, enzymes for DNA replication
S - DNA synthesis. Low rates of RNA transcription
G2 - High production of microtubules

M - mitosis

Question 2

Complications of cyclophosphamide

Answer 2

1. Interstitial pneumonitis - low doses for prolonged duration
2. Interstitial fibrosis - high doses for prolonged duration
3. Severe cardiotoxicity including pericardial effusion/pericariditis – high doses in short duration e.g. bone marrow transplant