Oncology

Question 1

WAGR is a heritable condition associated with which neoplasm? What gene is involved? Other manifestations?

Answer 1

Wilms tumor
WT1/deletion chromosome 11p13
Aniridia, Genitourinary anomaly, mental retardation

Question 2

Beckwith-Wiedemann is associated with which neoplasm? What genes are involved? Other clinical manifestations?

Answer 2

Wilms tumor
WT2/chromosome 11p15 Uni parental disomy
Hemihypertrophy, large tongue, omphalocele or umbilical hernia at birth, creases or pits in the skin near the ears, kidney abnormalities, neonatal hypoglycemia

Question 3

Adolescent presents with unilateral bone pain, palpable hard mass/swelling. XR shows periosteal new bone formation. What is the most likely diagnosis? Where is the most common site of metastasis? What study is necessary to asses for metastatic spread

Answer 3

Osteosarcoma
Lung is most common site of metastasis
CT of chest to evaluate for metastatic spread

Question 4

Male patient with bone pain worse at night. XR shows central radio lucena area surrounded by thick sclerotic bone. What is the most likely diagnosis?

Answer 4

Osteoid osteoma

Question 5

What are the lab findings in tumors lysis syndrome?

Answer 5

Hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and uremia