Oncology

Question 1

What is the recommended treatment for massive hepatocellular carcinoma?
MST without treatment in dogs?
with treatment in dog and cats?
metastatic rate?

Answer 1

• surgical resection
• MST without surgery -270d
• MST with surgery >1460d in dogs and 2.4y in cats
• variable metastatic rate reported. higher with diffuse (100%) and nodular (93%) compared to massive form

other treatments include:

• chemoembolisation
• Rt
• chemo: gemcytabine

Selmic VCNA 2017

Question 2

What are the two major categories of chronic lymphocytic leukaemias?

Answer 2

B-cell CLL => small and CD21 generally
CD8 T-cell CLL or large granular lymphocyte leukaemia. most common. => CD8+ CD45+ T cells
- CD8 Tzone leukaemia/lymphoma lacks CD45 antigen

vcna 2017

Question 3

What are teh major classes of acute leukaemias:

Answer 3

1. Acute lymphocyte leukaemia = CD5+ CD34+ Tcell ALL

2. Acute myeloid leukaemia =CD14+ CD34
Can also have a MHC class II - subset

3. Acute undifferentiated leukaemia=CD5+ CD14+

generally produce CD34 marker (Stem cell)

Question 4

What % of cats treated for small cell GI lymphoma develop large cell lymphoma?
What is the MST once they have developed this?
what other monitored factors change with this disease transition?

Answer 4

9.9%
MST 55 days from LCL diagnosis

concurrent changes noted including:

• weight loss
• anaemia
• hypoalbuminaemia
• hypoproteinaemia

Wright JFMS 2019