Oncogenic microbes and carcinogens Flashcards
EBV
Burkitt lymphoma, Hodgkin lymphoma,
nasopharyngeal carcinoma, 1° CNS
lymphoma (in immunocompromised patients)
HBV, HCV
HCC
HHV-8
Kaposi sarcoma
HPV
Cervical, penile, anal carcinoma (types 16, 18). Head and neck cancer
H. pylori
Gastric adenocarcinoma and MALT lymphoma
HTLV-1
Adult T cell leukemia/lymphoma
Clonorchis sinensis (liver fluke)
Cholangiocarcinoma
Schistosoma haematobium
Bladder cancer, squamous cell
What is known to produce aflatoxins?
aspergillus - can contaminate stored rice and grains
Organ toxicity of aflatoxins?
Liver
Cancer impact of aflatoxins?
Hepatocellular carcinoma
Organ toxicity of alkylating agents?
Blood
Cancer impact of alkylating agents?
Leukemia/lymphoma
Organ toxicity of aromatic amines (eg benzidine, 2-napthylamine)?
Bladder
Cancer impact of aromatic amines (eg benzidine, 2-napthylamine)?
Transitional cell carcinoma
Source of aromatic amines?
Cigarette smoke
Organ toxicity of arsenic?
Liver, Lung, Skin
Cancer impact of arsenic?
Angiosarcoma of liver
Lung Cancer
Squamous cell carcinoma of skin
Source of arsenic?
Cigarette smoke
Organ toxicity of asbestos?
Lung
Cancer impact of asbestos?
Bronchogenic carcinoma>mesothelioma
Organ toxicity of carbon tetrachloride?
Liver
Cancer impact of carbon tetrachloride?
Centrilobular necrosis, fatty change
Organ toxicity of cigarette smoke?
Esophagus Larynx Lung Pancreas Kidney Bladder Cervix
Cancer impact of cigarette smoke?
Esophagus - SCC/adeno Larynx - SCC Lung - Sq, small cell Pancreas - adenocarcinoma Kidney - renal cell ca Bladder - transitional Cervix - carcinoma
Organ tox of ethanol?
Esophagus, Liver
Cancer impact of ethanol?
SCC of eso/oropharynx
HCC of liver
Organ tox of ionizing radiation?
Thyroid
Cancer impact of ionizing radiation?
Papillary thyroid carcinoma
Source of Nitrosamines?
Smoked foods (japan!)
Organ toxicity of nitrosamines?
Stomach
Cancer impact of nitrosamines?
gastric cancer
Organ impact of Radon?
Lung
Cancer impact of Radon?
Lung Ca - 2nd leading cause after smoking
Vinyl chloride source?
Occupational exposure - used to make PVC pipes
Organ tox of vinyl chloride?
Liver
Cancer impact of vinyl chloride?
Angiosarcoma
Nickel/chromium, beryllium, or silicia
Lung carcinoma