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Pathology - Neoplasia > Disease Conditions Associated w/ Neoplasms > Flashcards

Disease Conditions Associated w/ Neoplasms Flashcards

1
Q

Acanthosis nigricans

A

Rare paraneoplastic indicator of visceral malignancy (more commonly associated with insulin
resistance)

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2
Q

Barrett esophagus

A

Precursor to esophageal adenocarcinoma

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3
Q

Chronic atrophic gastritis, post-surgical gastric remnants

A

Predispose to gastric adenocarcinoma

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4
Q

Cirrhosis

A

Predisposes to hepatocellular carcinoma

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5
Q

Ulcerative colitis

A

Predisposes to colon adenocarcinoma

AND cholangiocarcinoma!

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6
Q

Actinic keratosis

A

Precursor to squamous cell carcinoma of the skin

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7
Q

Dermato/polymyositis

A

Predispose to visceral malignancies, particularly genitourinary

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8
Q

Dysplastic nevus

A

Precursor to malignant melanoma

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9
Q

Multiple seborrheic ketatoses

A

Leser-Trelat sign: GI, breast, lung, and lymphoid malignancies

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10
Q

Paget disease of the bone

A

Predisposes to 2° osteosarcoma and fibrosarcoma

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11
Q

Plummer-Vinson syndrome

A

Predisposes to squamous cell carcinoma of the esophagus

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12
Q

Tuberous sclerosis

A

Often manifests with multiple hamartomatous (benign) tumors including giant cell astrocytomas,
renal angiomyolipomas, cardiac rhabdomyomas; tumors may become malignant

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13
Q

Xeroderma pigmentosum, albinsim

A

Predispose to squamous cell carcinoma, basal cell carcinoma, melanoma

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14
Q

AIDS

A

Predisposes to aggressive lymphoma (non-Hodgkin) and Kaposi sarcoma

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15
Q

Autoimmune disease (eg Hashimoto/SLE)

A

Predispose to lymphoma

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16
Q

Down syndrome

A

Predisposes to acute lymphocytic leukemia

17
Q

Immunodeficiency

A

Predisposes to lymphoma, melanoma, renal cell carcinoma

18
Q

Li-Fraumeni syndrome?

A

p53 mutation predisposes to various cancer types at a young age (e.g., sarcoma, breast, leukemia,
adrenal gland)

19
Q

Radiation exposure

A

High risk of developing leukemia, sarcoma, papillary thyroid cancer, breast cancer

Pathology - Neoplasia (8 decks)

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