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Pathology > Oncogenes and tumor suppressor genes > Flashcards

Oncogenes and tumor suppressor genes Flashcards

1
Q

BCR-ABL

A

GOF Tyrosine kinase: CML, ALL

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2
Q

BCL-2

A

GOF Antiapoptotoic molecule: Follicular/undifferentiated lymphomas

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3
Q

BRAF

A

GOF Serine/threonine kinase: Melanoma, nonHodgkin lymphoma

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4
Q

c-kit

A

GOF Cytokine receptor: Gastrointestinal stromal tumor

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5
Q

c-myc

A

GOF Transcription factor: Burkitt lymphoma

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6
Q

HER2/neu

A

GOF Tyrosine kinase: Breast, ovarian, gastric carcinomas

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7
Q

L-myc

A

GOF Transcription factor: lung tumor

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8
Q

N-myc

A

GOF Transcription factor: Neuroblastoma

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9
Q

RAS

A

GOF GTPase: Colon cacner, lung cancer, pancreatic cancer

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10
Q

RET

A

GOF Tyrosine kinase: MEN2A, MEN2B, medullary thyroid cancer

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11
Q

APC

A

Colorectal cancer associated with FAP (LOF)

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12
Q

BRCA1/BRCA2

A

Breast and ovarian: LOF DNA repair protein gene

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13
Q

DCC

A

Colon cancer: LOF DCC gene (“Deleted in colon cancer”)

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14
Q

DPC4/SMAD4

A

Pancreatic cancer LOF DPC gene (“Deleted in pancreatic cancer”)

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15
Q

MEN1

A

MEN1: LOF Menin gene

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16
Q

NF1

A

NF1: LOF RAS GTPase activating protein (neurofibromin)

17
Q

NF2

A

NF2: LOF merlin (schwannomin protein)

18
Q

p16

A

Melanoma: LOF cyclin-dependent kinase inhibitor 2A

19
Q

p53

A

Most human cancers/Li-Fraumeni: LOF Transcription factor for p21, blocks G1–>S phase

20
Q

PTEN

A

Breast, prostate, endometrial cancer

PTEN~Prostate, tits, endometrial

21
Q

Rb

A

Osteosarcoma, Retinoblastoma: LOF inhibitor E2F, blocks G1->S phase

22
Q

TSC1

A

Tuberous sclerosis: LOF Hamartin protein

23
Q

TSC2

A

Tuberous sclerosis: LOF Tuberin protein

24
Q

VHL

A

von Hippel-Lindau/renal cell carcinoma: LOF inhibitor of hypoxia inducible factor 1a

25
Q

WT1/WT2

A

Wilms Tumor “nephroblastoma”

Pathology (5 decks)

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