Disease conditions associated with neoplasms

Question 1

Acanthosis nigricans

Answer 1

Rare paraneoplastic indicator of visceral malignancy

*More commonly associated with insulin resistance

Question 2

Barrett esophagus

Answer 2

Precursor to esophageal adenocarcinoma

Question 3

Chronic atrophic gastritis, postsurgical gastric remnants

Answer 3

Predispose to gastric adenocarcinoma

Question 4

Cirrhosis

Answer 4

Predisposes to hepatocellular carcinoma

Question 5

Ulcerative colitis

Answer 5

Predisposes to colon adenocarcinoma

Question 6

Actinic keratosis

Answer 6

Precusor to squamous cell carcinoma of the skin

Question 7

Dermato/poly-myositis

Answer 7

Predispose to visceral malignancies (particularly GU)

Question 8

Dysplastic nevus

Answer 8

Precursor to malignant melanoma

Question 9

Multiple seborrheic keratoses

Answer 9

Leser-Trelat

GI, breast, lung and lymphoid malignancies

Question 10

Paget disease of the bone

Answer 10

Secondary osteosarcoma and fibrosarcoma

Question 11

Plummer-Vinson syndrome

Answer 11

Squamous cell carcinoma of the esophagus

Question 12

Tuberous sclerosis

Answer 12

Multiple hamartomas: giant cell astrocytomas, renal angiomyolipomas, cardiac rhabdomyomas
Tumors may become malignant

Question 13

Xeroderma pigmentosum, albinism

Answer 13

Squamous cell carcinoma, basal cell carcinoma, melanoma

Question 14

AIDS

Answer 14

Predisposes to aggressive lymphoma (non-Hodgkin) and Kaposi sarcoma

Question 15

Autoimmune diseases (Hashimoto thyroiditis, SLE)

Answer 15

Predisposes to lymphoma

Question 16

Down syndrome

Answer 16

Predisposes to acute lymphocytic leukemia

Question 17

Immunodeficiency

Answer 17

Predisposes to lymphoma, melanoma, renal cell carcinoma

Question 18

Li-Fraumeni syndrome

Answer 18

p53 mutation predisposes to various cancer types at a young age
Sarcoma, breast, leukemia, adrenal gland

Question 19

Radiation exposure

Answer 19

High risk of developing leukemia, sarcoma, papillary thyroid cancer, breast cancer