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Pathology > Carcinogens: Organ & Impact > Flashcards

Carcinogens: Organ & Impact Flashcards

1
Q

Aflatoxins

A

Liver: Hepatocellular carcinoma

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2
Q

Alkylating agents

A

Blood: leukemia/lymphoma

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3
Q

Aromatic amines (benzidine, 2-naphthylamine)

A

Bladder: transitional cell carcinoma

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4
Q

Arsenic

A

Liver: Angiosarcoma
Lung: lung cancer
Skin: Squamous cell cancer

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5
Q

Carbon tetrachloride (used to be in fire extinguishers)

A

Liver: Centrilobular necrosis, fatty change

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6
Q

Asbestos

A

Lung: Bronchogenic carcinoma>mesothelioma

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7
Q

Cigarette smoke

A 
Bladder: Transitional cell carcinoma
Cervix: Cervical carcinoma
Esophagus: squamous cell/adeno-carcinoma
Kidney: renal cell carcinoma
Larynx: squamous cell carcinoma
Lung: squamous and small cell carcinoma
Pancreas: Adenocarcinoma
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8
Q

Ethanol

A

Esophagus: squamous cell carcinoma
Liver: hepatocellular carcinoma

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9
Q

Ionizing radiation

A

Thyroid: Papillary thyroid carcinoma

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10
Q

Nitrosamines

A

Stomach: Gastric cancer

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11
Q

Radon

A

Lung: lung cancer: second leading causes after smoking

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12
Q

Vinyl chloride

A

Liver: angiosarcoma

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13
Q

Paraneoplastic cancer: Hodgkin lymphoma

A

1, 25 OH-D3–>hypercalcemia

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14
Q

Paraneoplastic cancer: Non-hodgkin lymphoma

A

1,25-OH-D3–>hypercalcemia

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15
Q

Paraneoplastic cancer: Small cell lung carcinoma

A

ACTH–> Cushing syndrome
ADH –> SIADH
Anti-presynaptic Ca2+ channels at NMJ–>Lambert-Eaton Myasthenic syndrome (muscle weakness)

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16
Q

Paraneoplastic cancer: Renal cell carcinoma

A

ACTH: Cushing syndrome
EPO: Polycythemia
PTHrP: Hypercalcemia

17
Q

Paraneoplastic cancer: Intracranial neoplasms

A

ADH: SIADH

18
Q

Paraneoplastic cancer that elevate EPO

A 
Hepatocellular carcinoma
Renal cell carcinoma
Hemangioblastoma
Leiomyoma
Pheochromocytoma
=> Polycythemia
19
Q

Paraneoplastic cancer: Squamous cell lung cancer

A

PTHrP: Hypercalcemia

20
Q

Paraneoplastic cancer: Breast cancer

A

PTHrP: Hypercalcemia

Pathology (5 decks)

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