Oncogenes and Tumor Suppressor Genes Flashcards by Mitchell Bowman | Brainscape

Q

What is an oncogene?

A

Mutation of ONE allele = cancer

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Q

What is a tumor suppressor gene?

A

Mutation of BOTH alleles = cancer

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Q

Associated cancer and gene product of abl?

A

Oncogene

CML

Tyrosine kinase

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Q

Associated cancer and gene product of c-myc?

A

Oncogene

Burkitt’s Lymphoma

Transcription factor

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Q

Associated cancer and gene product of bcl-2?

A

Oncogene

Follicular/undifferentiated lymphomas

Anti-apoptotic protein

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Q

Associated cancer and gene product of HER2?

A

Oncogene

Breast, ovarian, gastric cancers

Tyrosine kinase

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Q

Associated cancer and gene product of ras?

A

Oncogene

Colon cancer

GTPase

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Q

Associated cancer and gene product of L-myc?

A

Oncogene

Lung tumor

Transcription factor

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Q

Associated cancer and gene product of N-myc?

A

Oncogene

Neuroblastoma

Transcription factor

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Q

Associated cancer and gene product of ret?

A

Oncogene

MEN 2A and 2B

Tyrosine kinase

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Q

Associated cancer and gene product of c-kit?

A

Oncogene

GIST

Cytokine receptor

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Q

Associated cancer and gene product of Rb?

A

Tumor Suppressor gene

Retinoblastoma and Osteosarcoma

InhibitsE2F; blocks G1 –> S

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Q

Associated cancer and gene product of p53?

A

Tumor Suppressor gene

Most cancers

Transcription factor for p21; blocks G2 –> S

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Q

Associated cancer and gene product of BRCA1?

A

Tumor Suppressor gene

Breast, ovarian

DNA repair protein

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Q

Associated cancer and gene product of BRCA2?

A

Tumor Suppressor gene

Breast, ovarian

DNA repair protein

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Q

Associated cancer and gene product of p16?

A

Tumor Suppressor gene

Melanoma

Q

Associated cancer and gene product of BRAF?

A

Tumor Suppressor gene

Melanoma

B-raf

Q

Associated cancer and gene product of APC?

A

Tumor Suppressor gene

Colorectal cancer

Q

Associated cancer and gene product of WT1?

A

Tumor Suppressor gene

Wilm’s tumor (nephroblastoma)

Q

Associated cancer and gene product of NF1?

A

Tumor Suppressor gene

Neurofibromatosis type 1

RAS GTPase activating protein (RAS GAP)

Q

Associated cancer and gene product of NF2?

A

Tumor Suppressor gene

Neurofibromatosis type 2

Merlin (schwannomin) protein

Q

Associated cancer and gene product of DPC4?

A

Tumor Suppressor gene

Pancreatic cancer

DPC (Deleted in Pancreatic Cancer)

Q

Associated cancer and gene product of DCC?

A

Tumor Suppressor gene

Colon cancer

DCC (Deleted in Colon Cancer)