Oncogenes and signalling pathways

Question 1

PTEN is implicated in?

Answer 1

Deletion or silencing of PTEN

-Involved in PI3K-AKT pathway –> Increased PDL1 expression

Question 2

Anaplastic lymphoma kinase signalling involved in ?

Answer 2

drive PDL1 expression through signal transducer and activator of transcription 3 (STAT3) signalling