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Immunotherapy & TME > Immuno-oncology and Ovarian Cancer > Flashcards

Immuno-oncology and Ovarian Cancer Flashcards

1
Q

Is PDL1 highly expressed in ovarian cancer?

A

Yes

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2
Q

List some cytokines/ILs that contribute to the immunosuppressive pathway in EOC.

A

overexpression of

  • tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO)
  • IL6
  • IL-10
  • PGE2
  • VEGF
  • TGF-Beta
  • arachadonic acid
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3
Q

What are prognosticators in EOC in terms of immune cells?

A

Poor prognosticator: CD163+ TAMs, C8+ TILs

Good prognosticator: high M1/M2

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Immunotherapy & TME (8 decks)

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