Oligoclonal Bands Flashcards
1
Q
What do oligoclonal bands indicate in protein electrophoresis?
A
- Oligoclonal bands indicate immunoglobulin production.
2
Q
Where are oligoclonal bands typically located in the protein electrophoresis spectrum?
A
- Are located in the gamma region of the protein electrophoresis spectrum.
3
Q
What does the presence of oligoclonal bands in CSF indicate?
A
- Can indicate multiple sclerosis or other neurologic disorders
- Such as encephalitis, neurosyphilis, or Guillain-Barre Syndrome.
4
Q
What does the presence of oligoclonal bands in serum and CSF indicate?
A
- Suggests a potential immune response in individuals with HIV infection.
5
Q
What conditions may be associated with the presence of oligoclonal bands in serum only?
A
- May be associated with conditions such as leukemia, lymphoma, and viral infections.
6
Q
Why might CSF banding occur in cases of oligoclonal bands in serum only?
A
- May occur in such cases due to blood-brain barrier (BBB) leakage or blood contamination during a lumbar tap.
7
Q
What is the charge of the anode?
A
- The anode is negatively charged.
8
Q
What is the charge of the cathode?
A
- The cathode is positively charged.
9
Q
Where does protein migrate to in this setup?
A
- Proteins migrate to the cathode.
