CSF Glutamine

Question 1

How is CSF glutamine indirectly measured?

Answer 1

• CSF glutamine is indirectly measured through CSF ammonia levels.

Question 2

Why is CSF glutamine preferred over the direct measurement of CSF ammonia?

Answer 2

• CSF glutamine is preferred because ammonia is volatile and easily evaporates, making it challenging to measure accurately.

Question 3

What are the normal values for CSF glutamine, and what condition is associated with elevated levels of CSF glutamine?

Answer 3

• The normal values for CSF glutamine are 8-18mg/dL.
• Elevated levels of CSF glutamine are associated with liver disorders that result in increased blood and CSF ammonia.

Question 4

What is the source of glutamine in the cerebrospinal fluid (CSF)?

Answer 4

• Glutamine in CSF is produced from ammonia and a-ketoglutarate by brain cells.

Question 5

Why is the production of glutamine from ammonia significant in the CNS?

Answer 5

• This process helps remove ammonia from the central nervous system (CNS).

Question 6

toxic to CNS tissue

Answer 6

• Ammonia

Question 7

How is glutamine used as an indirect test in CSF?

Answer 7

• Glutamine levels in CSF are used as an indirect test to assess the presence of excess ammonia.

Question 8

In what clinical scenario is CSF glutamine frequently requested?

Answer 8

for patients with coma of unknown origin.

Question 9

In what condition is there an increase in approximately 75% of children concerning CSF glutamine?

Answer 9

• An increase in CSF glutamine is observed in approximately 75% of children with Reye Syndrome.