Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharamcology Endocrine > Oestrogen > Flashcards

Oestrogen Flashcards

1
Q

Which types of Oestrogens are found in the liver from oestradiol

A
  1. Estrone
  2. estriol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Classify oestrogen drugs

A
  1. Natural oestrogen
  2. Synthetic - 1. steroidal 2. nonsteroidal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name natural oestrogens

A
  1. Estradiol
  2. Estriol
  3. Estrone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Name synthetic steroidal oestrogens

A
  1. Ethinyl Estradiol
  2. Mestranol
  3. Tibolone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name synthetic nonsteroidal estrogens

A
  1. Diethylstilbestrol
  2. Dienestrol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the actions of oestrogen

A
  1. Development of Sex organs in females
  2. Proliferative phase of endometrium
  3. contractions of fallopian tube and myometrium
  4. cervical secretions are thin
  5. stimulates growth of breasts
  6. decrease the rate of reabsorption of bone, increase HDL, sodium water retention
  7. enhance coagulability of blood by increasing clotting factors 2, 7, 9, 10
  8. induced synthesis of progesterone receptors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the actions of progestins

A
  1. Maintain pregnancy
  2. secretory phase of endometrium
  3. decrease tubal motility and uterine contractions
  4. cervical mucus becomes thick
  5. stimulates proliferation of breast acini
  6. decrease glucose tolerance, increase LDL, stimulate lipoprotein lipase, sodium and water retention.
  7. increase body temperature
  8. inhibit synthesis of oestrogen receptors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are therapeutic uses of oestrogen

A
  1. Oral contraception
  2. post menopausal hormone replacement therapy
  3. senile vaginitis
  4. dysmenorrhoea
  5. delayed puberty in girls (turner’s) syndrome and hypopituitarism
  6. carcinoma of prostate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

In hormone replacement therapy, in which condition is oestrogen used alone in women

A

Women who have had Hysterectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the drawbacks of hormone replacement therapy

A
  1. Uterine bleeding
  2. Venous thromboembolism
  3. gall stones
  4. mood changes
  5. breast cancer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which drug has both osteogenic, progestogenic, And weekend and activities and does not cause endometrial proliferation can be used for HRT without cyclic progesterone

A

Tibolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the adverse affects of using oestrogen

A
  1. oedema
  2. weight gain
  3. nausea, vomiting
  4. breast tenderness
  5. endometrial and breast cancer
  6. thromboembolic complications
  7. increased incidence of gall stones
  8. liver disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name anti-estrogen

A
  1. Clomiphene citrate
  2. Fluvestrant
  3. Tamoxifen
  4. raloxifene
  5. Ormeloxifene
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Name oestrogen receptors

A
  1. ER -alpha
  2. ER- beta
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the Uses of Clomiphene citrate

A
  1. Infertility
  2. assisted reproduction therapy ART and gamete intra-fallopian transfer technique GIFT
  3. Male infertility
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the adverse effects of clomiphene citrate

A
  1. Hot flashes, nausea, vomiting, headache
  2. loss of hair
  3. hyperstimulation syndrome
  4. multiple pregnancy, ovarian cyst, ovarian malignancy
  5. breast discomfort
  6. weight gain
17
Q

Name selective ER modulators

A
  1. Tamoxifen
  2. raloxifene
  3. ormeloxifene
18
Q

Name selective oestrogen receptor modulators

A
  1. Tamoxifen
  2. ormeloxifene
  3. raloxifene
19
Q

What are the actions of tamoxifen

A
  1. Endometrial proliferation
  2. decreases rate of bone resorption
  3. Reduce cholesterol and LDL levels
20
Q

What are the uses of tamoxifen

A

Carcinoma of the breast in both pre-menopausal woman and postmenopausal woman

21
Q

What are the adverse effects of tamoxifen

A
  1. Endometrial cancer
  2. hot flashes
  3. Venous thrombosis
  4. nausea and vomiting
22
Q

What is the use of Raloxifene

A

Treatment of osteoporosis in menopausal woman

23
Q

What are the adverse effects of raloxifene

A
  1. Deep vein thrombosis
  2. hot flushes
  3. leg cramps
  4. pulmonary embolism
24
Q

What are the uses and side effects of ormeloxifene

A

Use- Treatment of dysfunctional uterine bleeding
Adverse effects- headache, weight gain and nausea

Pharamcology Endocrine (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions