Oesophageal disorders Flashcards
Define dyspepsia
Upper GI symptoms typically present for 4+ weeks, including: upper abdominal pain/discomfort, heartburn, acid reflux, NaV
Define GORD
Gastro-oesophageal reflux disease is a chronic condition of abnormal reflux of gastric contents into the oesophagus, which causes predominant symptoms of heartburn and acid regurgitation.
What is ‘proven GORD’?
Endoscopically-determined reflux disease
How does GORD typically present?
Oesophageal symptoms: Heartburn (25%) - burning retrosternal discomfort Acid brash - acid or bile regurgitation Water brash - excessive salivation Odynophagia - pain on swallowing
Name 3 atypical clinical features of GORD
Extra-oesophageal symptoms (atypical): Chest pain, epigastric pain, bloating Nocturnal asthma Chronic cough Laryngitis (Cherry-Donner syndrome) Sinusitis
Name 5 risk factors for GORD
Lifestyle: obesity, trigger foods, smoking, alcohol, coffee, stress
Drugs: CCBs, anticholinergics, theophylline, BDZs, nitrates
Pregnancy
What complications can occur due to GORD?
Oesophagitis Ulcers Benign strictures Iron-deficiency anaemia Barrett's oesophagus ➔ Oesophageal adenocarcinoma
What is Barrett’s oesophagus?
A precancerous stage seen in 10-15% GORD, associated with the development of oesophageal adenocarcinoma (1-10% in next 20yr).
Metaplasia of oesophageal stratified squamous epithelium ➔ simple columnar epithelium
Name 3 causes of GORD
Lower oesophageal sphincter problems
Delayed gastric emptying e.g. gastric outlet obstruction
Hiatus hernia
Obesity/pregnancy
What may be seen on histology of GORD?
Gastric metaplasia ➔ low risk of malignancy
Intestinal metaplasia ➔ 2 yearly surveillance
Low-grade dysplasia ➔ 90% develop cancer within 6yr
High-grade dysplasia ➔ 50% have adenocarcinoma
What is used to grade Barrett’s oesophagus?
Prague C and M endoscopic grading system
How is Barrett’s oesophagus treated?
High-grade dysplasia: Surgical resection, endoscopic mucosal resection, or ablation
Name 3 differential diagnoses for GORD
Oesophagitis from: Corrosives NSAIDs Herpes Candida
Peptic ulcer disease
Cancer
Cardiac cause e.g. MI
Describe the pathology of strictures in GORD
Chronic fibrosis and epithelial destruction
Eventual shortening and narrowing of the lower oesophagus ➔ potential fixation and susceptibility to further reflux
What are the annual and lifetime recurrence risks of GORD? Which patient group is more likely to relapse?
Annual recurrence risk of untreated GORD: 50%
Lifetime risk of recurrence: 80%
More likely to relapse in people with severe oesophagitis
Name 4 indications for investigations for GORD
Age >45 Symptoms last >4wks Persistent vomiting GI bleeding or iron deficiency Palpable mass Dysphagia Weight loss Failed medical treatment
Why could OGD be preformed for any presentation of GORD in over 45s?
Exclude oesophageal malignancy
How is GORD investigated?
Endoscopy
24h continuous pH monitoring +- manometry
Barium swallow - may show hiatus hernia
Describe a positive pH investigation result for GORD
GORD symptoms correspond with pH peaks
What physiological features protect against GORD?
Lower oesophageal sphincter
Fundus located posteriorly and superiorly
Crus of diaphragm
Expansion of stomach
Outline the lifestyle management of GORD
Smoking cessation Weight loss Decrease alcohol consumption Small regular meals Avoid trigger foods Sleep with head of bed raised