Anal disorders Flashcards

1
Q

Define haemorrhoids

A

Abnormal vascular dilatation of anal mucosal cushions

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2
Q

How are haemorrhoids classified?

A

External or internal depending on origin in relation to the dentate line (transition between upper and lower anal canal).

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3
Q

Define external haemorrhoids (3)

A

Originate below dentate line
Covered by modified squamous epithelium (anoderm)
Richly innervated with pain fibres ➔ itchy and painful

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4
Q

Define internal haemorrhoids

A

Originate above dentate line
Covered by columnar epithelium
No pain fibres ➔ not sensitive to touch, temperature, or pain (unless strangulated)

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5
Q

What and where is the dentate line?

A

The transition between the upper and lower anal canal. Located 2cm from the anal verge.

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6
Q

Outline grading of internal haemorrhoids

A

I. project into lumen of anal canal but does not prolapse

II. prolapse on straining but reduce spontaneously when straining stops

III. prolapse on straining and requires manual reduction

IV. prolapsed and incarcerated and cannot be reduced

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7
Q

List 3 risk factors for haemorrhoids

A
Constipation
Straining while trying to pass stools
Increasing age
Heavy lifting
Chronic cough
Pregnancy, childbirth
Obesity
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8
Q

Name 3 complications of haemorrhoids

A
Ulceration
Skin tags
Maceration of perianal skin (softening and breakdown of skin)
Ischaemia
Thrombosis
Gangrene

Rare: perianal sepsis, anaemia

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9
Q

Describe the presentation of haemorrhoids

A

Bright red, painless rectal bleeding (not mixed with faeces)
Discomfort
Pruritus ani
Tenesmus

Pain if Grade IV internal haemorrhoid or thromboses external haemorrhoid

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10
Q

How are haemorrhoids investigated?

A

Proctoscopy

Sigmoidoscopy: used if sinister symptoms are present or elderly

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11
Q

Outline the non-pharmacological management of haemorrhoids

A

Healthy, high fibre diet
Increased fluid intake
Minimising straining
Good anal hygiene: aids healing, reduces irritation

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12
Q

Outline the pharmacological management of haemorrhoids

A

Simple analgesia e.g. paracetamol
Consider topical analgesia
-avoid NSAIDs if rectal bleeding present
Faecal softeners (decusate sodium and glycerol suppositories)
Laxative: osmotic movicol, or bulk fibrogel

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13
Q

Outline the secondary care management of haemorrhoids

A

Band ligation
Injection sclerotherapy

Haemorrhoidectomy
Haemorrhoidal artery ligation (HALO)

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14
Q

Define anal fissure

A

A tear or ulcer in the lining of the anal cannel, immediately within the anal margin

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15
Q

What is the commonest age group affected by anal fissures?

A

15-40yrs

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16
Q

Describe the presentation of anal fissure

A

Anal pain with defecation +/- bright red rectal bleeding

Anal spasm

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17
Q

Differentiate between acute and chronic anal fissures

A

Acute (<6wk) are superficial with well-demarcated edges

Chronic (6+wk) are wider and deeper with muscle fibres visible in the base. Edges often swollen, and skin tag may be visible.

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18
Q

Outline the non-pharmacological management of anal fissures

A

High fibre diet
Increased fluid intake
Avoid straining
Good anal hygiene

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19
Q

Outline the pharmacological management of chronic anal fissures

A

Analgesia
GTN 0.4% cream - if unhealed after 6-8wk with notable symptomatic improvement
Topical diltiazem 2% cream - if unhealed after 6-8wk, but no notable symptomatic improvement

Botox injection into internal sphincter

20
Q

Outline the surgical intervention for anal fissures

A

Lateral sphincterotomy - reduces internal sphincter spasms that impaired anal blood supply and reduced fissure healing

Avoid in females due to complications with childbirth and UTIs

21
Q

Describe the presentation of perianal abscess

A

Gradual onset, constant localised perianal pain
Associated swelling with tenderness +/- discharge
May have associated systemic features: fever, malaise, anorexia

22
Q

Name 2 organisms commonly implicated in perianal abscess

A

E. coli
Enterococcus spp.
Bacteroides spp.

23
Q

Name 3 risk factors of perianal abscess

A
Crohn's disease
Diabetes mellitus
Anal fistula
Steroid use
Immunodeficiency
24
Q

Outline the management of perianal abscess

A

Surgical emergency

Incision and drainage

25
Describe the pathophysiology of perianal abscess and subsequent fistula
Crypts of Morgagni that penetrate the internal sphincter become infected. This allows pus to tract to the anal margin and form an abscess. If the abscess resolves, there is a fistula in this location connecting the anal cavity to the perianal skin.
26
Outline the management of anal fistula
Seton stitch: A thread inserted through the fistula tract and tied outside in a loop. This allows the infection to drain and heal, without damaging the sphincter muscles. Fistulotomy: Laying open of the fistula to allow healing by secondary intention.
27
Define pilonidal sinus disease
Skin disorder featuring openings in the midline of the natal cleft, that allow loose hair and debris to enter creating an epithelial track (sinus)
28
Name 3 risk factors for pilonidal sinus disease
``` Male 15-40yr Caucasian Hirsutism Obesity ```
29
Describe the presentation of pilonidal sinus disease
Asymptomatic, or Acute: pilonidal abscess Chronically discharging sinus
30
Name 2 complications of pilonidal sinus disease
Cellulitis Sepsis Chronic pain Altered body image
31
Outline the management of acute pilonidal abscess
Urgent incision and drainage Analgesia Advice to reduce recurrence: perianal hygiene, buttock hair removal techniques
32
Outline the primary care management of discharging pilonidal sinus disease
Refer to colorectal or general surgical unit Analgesia Antibiotics if cellulitis suspected
33
Outline the surgical management of discharging pilonidal sinus disease
For recurrent abscess or a small sinus ➔ pit picking method (removal of midline pit), excision of superficial abscess scars, drainage of track. For chronic discharging sinuses ➔ wide excision of sinus tracks + primary closure or leaving wound open to heal by secondary intention. Cover with tissue flap if possible to minimise infection risk.
34
What is the commonest type of anal cancer?
Squamous cell carcinoma (80%)
35
Name 3 types of anal cancer
Squamous cell carcinoma (80%) Melanoma Lymphoma Adenocarcinoma
36
Outline the epidemiology of anal cancer
Uncommon (only 4% of lower GI cancers) Incidence 1 in 10,000 F>M
37
Which anal cancers are commoner in men?
Anal margin tumours: well differentiates, good prognosis
38
Which anal cancers are commoner in women?
Anal canal tumours: poorly differentiated, worse prognosis
39
Where do anal cancers most commonly metastasise?
Liver | Lungs
40
Name 3 risk factors for anal cancer
Human papilloma virus (HPV): HPV risk increased by anal intercourse and high number of sexual partners Men who have sex with men HIV-positive Immunosuppression in transplant recipients Cigarette smoking Previous malignancy
41
Describe the presentation of anal cancer
``` Rectal bleeding (50%) Perianal pain Palpable lesion Faecal incontinence +/- mucus discharge Perianal pruritus ``` 20% asymptomatic
42
How should anal cancer be investigated?
Rectal examination and biopsy Staging: CT, MRI, endo-anal USS, PET HIV serology Metastases screening
43
What system is used to stage anal cancer?
TNM staging
44
Outline management of small well-differentiated carcinomas of the anal margin
Local excision
45
Outline management of anal cancers that are larger, poorly-differentiated, or outside of the anal margin
Combined modality chemotherapy (5-fluorouracil + mitomycin C) and radiotherapy Salvage surgery
46
What are the surgical indications for anal cancer?
Tumours that fail to respond to radiotherapy Large tumours causing GI obstruction Small anal margin tumours without sphincter involvement
47
Outline the pharmacological management of acute anal fissures
Bulk forming laxatives Non-opioid analgesia Topical anaesthetic