Ocular pharmacology Flashcards
what is the main barrier when it comes to delivering medication to the eye?
the cornea
hydrophilic drugs are limited by what and why?
the epithelium because its hydrophobic
hydrophobic drugs are limited by what and why?
the stroma because its hydrophilic
if you add alcohol/acetate to a steroid what does it do? e.g prednisolone acetate
makes it more hydrophobic
if you add phosphate to a steroid what does it do? e.g prednisolone phosphate
makes it more hydrophilic
route of administration?
subconjunctival
subtenons
ocular injections
who shouldnt you give topical steroids to?
somebody with a red eye!
when are topical steroids used?
post op
uveitis
to prevent corneal graft rejection
what are the local side effects of steroids?
cataract
glaucoma
exacerbation of viral infection
what is used in allergic conjunctivitis?
antihistamine and mast cell stabliser
first line for glaucoma
latanoprost
what do mydriatics do?
dilate the pupil by blocking parasympathetic nerve supply to iris
what drug can cause optic neuropathy?
ethambutol
what can chloroquine cause?
bulls eye maculopathy
