October 24

Question 1

Smoking

Answer 1

5 - 60% of available THC absorbed into body

Question 2

Dabbing

Answer 2

Highly concentrated THC; up to 80%

Question 3

Vaping

Answer 3

• Hash oil or marijuana in a vape device
  
  • Marijuana about 12% absorption; hash oil at least 60%

Question 4

Administration via ingestion

Answer 4

• Onset delayed
  
  • Acidic degradation, enzyme action, and first pass metabolism
  • Bioavailability of ingested THC is only between 4 and 12%
  • Longer lasting effects after absorption; no smoking effects

Question 5

Distribution

Answer 5

• THC is taken out of the blood quickly and moves into fatty tissue
  * 25 - 30% of single does can stay in fatty tissue for week
  * Continuous doses accumulate in fat and leech back into the system
  
  • Delay tends to form type of reverse tolerance to drug

Question 6

CBD

Answer 6

• Enters body similarly to THC
  
  • Skin permeability of CBD 10x higher than THC
  • ’Non-psychoactive’
    
    • May elevate other drug blood concentrations
  • Bioavailability of CBD via inhalation is 11 - 45%
    
    • Oral CBD is 6%

Question 7

THC metabolism

Answer 7

1.) 11-hydroxy-THC
* Active metabolite with similar effect
2.) 11-nor-9-carboxy-THC
* Not psychoactive

Question 8

CBD metabolism

Answer 8

• Approximately 40 metabolites
  
  • Major metabolite 7-hydroxycannabidiol (7-OH-CBD) is weaker, but bioactive