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OCB02 > OCB02-1017 Dentinogenesis > Flashcards

OCB02-1017 Dentinogenesis Flashcards

1
Q

What is dentineogenesis?

A

Formation of dentine

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2
Q

Where does dentineogenesis occur?

A

Dental papilla

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3
Q

What cells perform dentineogenesis?

A

odontoblasts

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4
Q

When does dentineogenesis occur?

A

Later bell stage

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5
Q

What do differentiating odontoblasts undergo rapid changes in?

A

size and polarisation

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6
Q

Where does cytodiffrentiation start?

A

tip of cusps or incised margins, and travels rootwards

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7
Q

What is the structure of the odontoblast?

A

Large nucleus at the basal part

Many small cell processes directed towards the basement membrane

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8
Q

Where is the predentine?

A

In the space between the odontoblast cell body and mental dentine

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9
Q

What colour is the staining of pre dentin?

A

Pale

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10
Q

What is another term for mineralisation front?

A

Metadentine

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11
Q

What is the mineralisation front?

A

It is part of the predentine, directly below mineralised dentine

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12
Q

What do odontoblast processes secrete?

A

Dentine phosphoprotein
Dentine sialophosphoprotein
Minerals associated with proteoglycans

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13
Q

Where does mineralisation start?

A

With mantle dentin and moves towards circumpulpal dentin

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14
Q

What occurs when the odontoblast secretes mantle dentin?

A

It buds off matrix vesicles which are 30-200nm in diameter

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15
Q

What is the purpose of alkaline phosphatase in the vesicles of mineralisation?

A

They increase PO43- concentration to develop crystals

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16
Q

Where are crystalline structures only present in?

A

Mantle dentine

17
Q

What is controlled to control odontoblasts?

A

Controlling influx of Ca2+ ions

Controlling secretion and metabolism of matrix proteins

18
Q

How does mineralisation of circcumpulpal dentine occur?

A

By Ca2+ nucleation at spaces present with bundles of collagen

19
Q

What controls mineralisation of circumpulpal dentine?

A

DPP

Dentine phosphoprotein

20
Q

What does it mean by circupulpal dentine having a linear mineralisation front?

A

The calcification of dentine appears uniform

21
Q

What are the properties of DPP?

A

Highly acidic so binds to Ca2+

Can change shape to bind Ca2+ ions to allow crystal growth

22
Q

What are the functions of DPP?

A

Transports Ca2+ to mineralisation front
Stabilisation of formed crystals
Inhibits crystal formation in high concentration

23
Q

What are the proteins of odontoblasts?

A

Osteonectin
Osteopontin
Boe Sialoprotein
Proteoglycans

24
Q

What does osteonectin do?

A

Inhibits growth of hydroxyapatite and promotes Ca2+ and Po4 3- binding to collagen

25
Q

What does osteopontin do?

A

Promotes mineralisation

26
Q

Where is bone sialoprotein found?

A

Early mineralising dentine, predentine and peritubular dentine

27
Q

What are circular areas of mineralisation called?

A

Calcospherites

28
Q

What are areas where calcospherites fail to fuse called?

A

Interglobular dentine

29
Q

When does the peritubular dentine layer form?

A

Same time as interlobular dentine

30
Q

What is root dentine initiated by?

A

The formation of HERS

31
Q

How does the rate of formation of root dentine differ to coronal dentine?

A

Root dentine forms slower than coronal dentine

32
Q

What is mineralisation like in multicoated teeth?

A

They have isolated areas of mineralisation

33
Q

What are the properties of root dentin (hyaline layer)?

A

No dentinal tubules

Non-collageous fibrillar matrix

34
Q

What signalling molecules are in tertiary dentine formation?

A

TGF-B

OCB02 (18 decks)

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