OCAT #1 Flashcards

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1
Q

steroid, slippery

A

lipophilic

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2
Q

gastric mucosa, cardiac muscle, mast cells, brain

A

H2

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3
Q

delivered by the post, can be done for later

A

packaged

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4
Q

acts on other cells

A

paracrine

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5
Q

activation of degranulation occurs

A

translocation

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6
Q

blocks response to receptor

A

antagonist

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7
Q

internal source chemical that calls for response

A

endogenous

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8
Q

enzyme that removes the carboxyl group

A

decarboxylase

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9
Q

VMAT2

A

Vesicular Monoamine Transporter 2

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10
Q

1st messenger introduced to the cell

A

transduction

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11
Q

connective tissue and mucosal, paracrine

A

mast cell

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12
Q

increases secretion of gastric acid

A

Glands

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13
Q

ring structure of histamine

A

imidazole

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14
Q

protein in granule during degranulation

A

VAMP

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15
Q

dendritic cells prevent antigen on membrane to trigger T cells

A

Contact dependent (need interaction between membrane molecules)

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16
Q

prominent in gut for stimulating gastric secretion

A

Enterochromaffin like (ECL) cells

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17
Q

exchanges protons from inside granule for histamine from cytoplasm

A

VMAT2 / contra transport

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18
Q

secretes hormones into the blood stream for long distance

A

endocrine cell

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19
Q

signal is more effective and stable

A

short distance

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20
Q

intracellular signalling pathway

A

DNA (transcription), RNA (translation), and Protein (enzymes and receptors)

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21
Q

sent out from sending cell to target cell

A

release

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22
Q

acts on self, spreads cancer

A

autocrine

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23
Q

promotes vasodilatation, causes edema

A

Vasculature

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24
Q

how ligands binding to receptors bring about an effect to a system

A

recognition, transduction, response

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25
Q

increase in size and loss of granule staining

A

activated mast cell

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26
Q

stops molecule from continuing signalling event

A

termination

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27
Q

pushing system to see what it does

A

functional

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28
Q

degradation termination intracellular

A

methyltransferase

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29
Q

fluorescent tagged antibodies

A

microscopy

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30
Q

specific hormone secreted into blood

A

neurohormone

31
Q

histamine, noradrenaline, acetylcholine

A

amine

32
Q

smooth muscle, endothelium, brain

A

H1

33
Q

external source chemical that calls for response

A

exogenous

34
Q

lipid bilayers are close and granules can flow out

A

fusion

35
Q

found in neurons, then in electrical synapse

A

gap junction (direct cytoplasmic connection)

36
Q

causes release of mediators

A

degranulation

37
Q

fat cell containing granules in different forms and locations

A

mast cell

38
Q

allergic conditions

A

H1

39
Q

image to show the surface structure of a cell

A

scanning electron microscope

40
Q

initiates physiological response when combine with receptor

A

agonist

41
Q

type of white blood cell

A

basophil

42
Q

when detected by target cell it is stimulated

A

a response

43
Q

converts a form of signal into another

A

signal transduction

44
Q

gastric acid secretion

A

H2

45
Q

H2 nobel prize

A

Black

46
Q

decreases camp

A

H3

47
Q

corticosteroids, prostaglandins

A

lipophilic mediators

48
Q

peptide, can not pass through membrane

A

hydrophilic

49
Q

categorized by distance between signalling and target cells

A

messenger molecule

50
Q

protein in membrane during degranulation

A

SNAP

51
Q

pumps protons into granule creating proton motive force

A

ATPase

52
Q

plasma membrane and vesicle are in close distance, stable complex formed

A

docking/priming

53
Q

increases camp

A

H2

54
Q

does not allow for endocrine or neuronal control

A

Ex-vivo (isolated tissues)

55
Q

image to show the internal structures of a mast cell

A

transmission electron microscopy

56
Q

Increases IP3, Diacylglycerol (DAG), intracellular Ca

A

H1

57
Q

toxic form with added carboxyl group

A

histidine

58
Q

do not express 1 type of histamine receptor

A

engineered mice

59
Q

activates other molecules in the cell

A

2nd messenger

60
Q

Decreases cAMP, increases intracellular Ca

A

H4

61
Q

chemicals secreted by neutrons that diffuse over small gaps

A

neurotransmitters

62
Q

common over the counter drugs

A

histamine receptor antagonists

63
Q

Production, Packaging, Release, Response, and Termination

A

extracellular communication

64
Q

difficult to generalize complex biological conditions

A

In-vitro (isolated cells)

65
Q

complex disease states (controlled enviro or clinical work)

A

In-vivo (organisms)

66
Q

H1 nobel prize

A

Bovet

67
Q

contraction of intestine, bronchioles

A

Smooth muscle

68
Q

measurement or assessment of structure, quantified property

A

structural

69
Q

delayed release of mediator in mast cell

A

leukotrienes

70
Q

degradation termination extracellular

A

diamine oxidase

71
Q

substance that induces immune response

A

antigen

72
Q

generic signalling molecule, in demand or in advance

A

produced

73
Q

increases heart rate

A

Cardiac muscle

74
Q

multiple cell types can be involved

A

Ex-vivo (isolated tissues)