Obs part 2 Flashcards
pre-existing DM - preconception A1C target
=<7.0%
ideally =<6.5%
pre-existing DM - pregnancy A1C target
=<6.5%
ideally =<6.1%
timing of delivery for GDM on insulin
at 39/40
timing of delivery for GDM diet
by 40/40
GDM - what proportion will develop T2DM later in life?
15-50%
50g GCT - normal result (at 1h)
<7.8 mmol/L
no further testing
GDM screening method
screening and diagnostic 2 step:
all pregnant women should be offered screening 24-28 wks with a 50g GCT
50g GCT - what value diagnoses GDM
> =11.1mmol/L
50g GCT - what values requires further testing with 2h 75g OGTT?
7.8-11.0 mmol/L
75g OGTT - GDM is diagnosed if:
following 50g GCT
- FPG >=5.3mmol/L
- 1h PG >= 10.6
- 2h PG >= 9.0
one step 75g OGTT - GDM is diagnosed if
- FPG >=5.1mmol/L
- 1h PG >=10.0
- 2h PG >=8.5
when to do early screening if high risk for GDM
24-48 weeks
RFs for early GDM screening
- Age >35
- BMI >30
- ethnicity
- FHx DM
- PCOS, acanthosis nigricans
- corticosteroid use
- prev GDM or macrosomia
fetal assessment in GDM or T1/T2
- USS growth + LV q3-4w from 28/40
- weekly wellbeing at 36/40
comorbid factors in DM indicating need for earlier onset and/or more frequent fetal surveillance
- obesity
- suboptimal glycemic control
- LGA (>90%) or SGA (<10%)
- previous SB
- HTN
if IUGR, addition of UA and MCA dopplers may be helpful
timing of delivery for pre-existing DM
38-40
depending on glycemic control and other co-morbidity factors
insulin adjustment for steroid admin
- D1 = increase night 25%
- D2/3 = increase all by 40%
- D4 = increase all by 20%
- D5 = increase all by 10-20%
- D6/7 = gradually taper
GDM followup testing - when and how?
75g OGTT
between 6w - 6m
postpartum OGTT - Normal results
- FPG <6.1
- 2h <7.8
- HbA1c <6%
postpartum OGTT - pre-diabetic ranges
- FPG 6.1-6.9
- 2h 7.8-11.0
- HbA1c 6.0-6.4%
postpartum OGTT - T2DM diagnosis
- FPG >=7.0
- RPG or 2h PG >=11.1
- HbA1c >=6.5
definition of microcephaly
HC =<3 SD below mean
alternative is <2centile
most common cause of microcephaly
- Unknown 41%
- Genetic - 20-30%; eg. PKU
- perinatal brain injury (including infxn) 27% congential CMV most common infectious
genetic causes have worse prognosis
microcephaly workup
- confirm GA
- complete maternal hx
- detailed 3-generation FhX
- detailed tertiary USS
- infection workup
- +/- MRI
- geneticist
- serial USS if continuing pregnancy
which side more common for DVT in pregnancy
LEFT leg
which side more common for ovarian vein thrombosis
RIGHT
EFM recommended for which class obesity
> 35 (ie class II and III)
bariatric surgery - who is eligible
- BMI >=40
- BMI >=35 with comorbidities
if not successful with other management strategies
pharmacotherapy for obesity - who is eligible
- BMI >=30
- BMI >=27 with comorbidities
orlistat or liraglutide
time to conception delay if bariatric surgery
24/12
inc risks of NICU, PTB, SGA
weight gain for singleton pregnancy in obesity
5-9kg
(11-20lbs)
better if weight gain in 2nd half
2100 kcal/day, inc to 2400 in 2nd trim
assessment of fetal wellbeing in obesity
- serial growth 28/32/36
- weekly wellbeing from 37/40 till delivery
timing of delivery for obesity
39-40/40
cs wound infection rate for BMI >50
30%
persistent risk regardless of MOD and abx prophylaxis
physical activity in pregnancy - recommendation
- >=150 min
- moderate intensity (aerobic and resistance best)
- over 3 or more days
below recommendation also incurred some benefit
physical activity in pregnancy showed a dose-response relationship for which outcomes?
- PET & PIH
- GDM
- PND