Gen Obs Flashcards
antihypertensives to be replaced for women planning pregnancy
ACEI or ARBs
PET screening at 11-14 weeks
Combination of
1. clinical risk markers
2. uterine artery PI
3. PlGF
when to start aspirin for PET prevention
preferably before 16 weeks;
till 36 weeks
calcium recommendation for PET prevention
500mg/d
if low dietary intake of calcium (ie <900mg/day)
when to initiate anti-HTN
140/90 or more
target DBP for pregnant women on meds with chronic HTN or PIH
85mmHG
when should PLT transfusion be considered for NVD and for CS
<20 x10^9 for vaginal delivery
or
<50 x10^9 for c/s,
or at any time if there is:
- excessive active bleeding
- known PLT dysfunction
- rapidly falling PLT count
- coagulopathy
Timing of delivery for chronic HTN
Initiation of delivery offered at 38-39+6
Advised from 40+0
timing of delivery for PIH
Initiation of delivery offered at 38-39+6
Advised from 40+0
HOWEVER, for women who are already at 37+0 and present with PIH, delivery should be discussed
timing of delivery for PET
Discuss initiation of delivery at 34-35+6.
Consider initiation delivery at 36-36+6
Recommend delivery at 37+0 or later
first line antiHTN for breastfeeding women
- labetalol
- methyldopa
- nifedipine
- enalapril or captopril
definition of hypertension (office based)
≥140 mm and/or ≥90 mm Hg,
based on the average of at least 2 measurements,
taken after 5 minutes’ rest, at least 15 minutes apart,
using the same arm
definition of HTN on home monitoring
> 135/85
thresholds for severe HTN and management
> 160/110:
admit to hospital and keep CTG on until BP stable
proteinuria values
- PCR >40mg/mmol urinary PCR on random spot test
- ACR >8mg/mmol
- 24h urine collection >0.3g/day
maternal surveillance for PIH
- test for PET to rule it out on diagnosis
- proteinuria testing at each subsequent antenatal visit
fetal surveillance for PIH
At diagnosis
1) angiogenic marker
2) USS (growth, LV, UA doppler)
Followup
1) repeat USS monthly
maternal surveillance for PET
at diagnosis
1. comprehensive testing for PET
- O2 sat
- PLT
- Serum creat
- AST or ALT
followup
2. maternal testing twice weekly
fetal surveillance for PET, or superimposed on chronic HTN
At diagnosis
1. angiogenic markers
2. USS
Followup
1. USS every 2 weeks for growth
2. USS at least once every 2 weeks for LV and UA doppler
definition of PET
gestation HTN with new-onset proteinuria, or one/more adverse conditions
(maternal end organ complication or evidence of uteroplacental dysfunction)
Adverse PET conditions/end organ dysfunction CNS
severe headache/visual symptoms
Adverse PET conditions/end organ dysfunction Cardio/resp
- chest pain/dyspnea
- O2 <97%
Adverse PET conditions/end organ dysfunction: Fetal
- Atypical/abnormal NST/CTG
- IUGR
- oligohydramnios
- AREDF on UA doppler
- angiogenic imbalance
(soluble fms-like tyrosine kinase-1:placental growth factor ratio of >85 by the Roche assay)
deliver regardless of gestational age for PET - CNS
- eclampsia
- PRES
- cortical blindness or retinal detachment
- GCS <13;
- Stroke, TIA or RIND (reversible ischemic neurological deficit <48h)
deliver regardless of gestational age for PET - Cardio/Resp
- uncontrolled severe HTN over a period of 12h despite use of 3 agents
- pulmonary edema
- positive inotropic support
- MI
- O2 <90%
- need for >50% O2 for >1h
- intubation (other than for CS)
delivery regardless of gestational age for PET - hematological
- PLT <50
- transfusion of any blood product
Indications to deliver regardless of gestational age for PET - renal
- AKI : Creat >150uM with no prior renal disease
- new indication for dialysis
Indications to deliver regardless of gestational age for PET - hepatic
- hepatic dysfunction : INR >2 in absence of DIC or warfarin
- hepatic hematoma or rupture
deliver regardless of gestational for PET - uteroplacental dysfunction
- abruption with evidence of maternal or fetal compromise
- Absent or reversed ductus venous a-wave
- IUFD
transient HTN - risk of progression to persistent HTN
40%
masked HTN - found in what % of pregnancy cases
30%
(vs 10% of cases outside of pregnancy)
An office BP <140/90 mm Hg, but an out-of-office BP ≥135/85 mm Hg
how often should maternal assessment be performed in PET
twice weekly
sensitivity of clinical risk factors for PET
<40%
high risk factors for PET (any 1)
- prior PET
- booking BMI >30
- Chronic HTN
- T1 or T2DM
- CKD
- SLE or APLS
- ART
Moderate risk factors for PET (2 or more)
prior
- abruption
- SB
- IUGR
Maternal:
- age >40
- nulliparity
- multifetal pregnancy
sensitivity of combining clinical, biochemical, and sonographic risk markers for PET
75% for pre-term PET
47% for term PET
ASPRE trial: 150mg of aspirin note reduced preterm PET by ___%
62% (to 1.6%)
but no effect on term PET.
NB - good adherence, 80%
daily dose of 91mg aspirin may be less effective based on _____, in up to ___% of women
platelet insensivity - 40%
adverse effects of ASA
- vaginal spotting
- APH
- PPH
- post partum hematom
- 0.06% increase in neonatal intracranial haemorrhage
high dose calcium supplementation should begin from ___ weeks, at ___ dose
from 20 weeks gestation at a dose of at least 1000mg/day
(for women with low dietary intake of <900mg)
calcium for prevention of PET in women with prior PET
500mg/day before pregnancy, and up to 20 weeks
then 1.5g/day after
need at least 80% adherence
physical activity for reduction of PET
to achieve a reduction of 25%, need at least 140 minutes per week of moderate-intensity exercise
stabilisation of maternal condition (PET) for transport
- BP <160/110
- meds given as needed
- pt is responsive or intubated/ventilated
- IV access established
- Foley catheter inserted
MGSO4 for eclampsia prophylaxis for transport
5g IM MgSO4 into each buttock (+/- xylocain 1% without epinephrine 2ml)
risk of status asthmatics in poorly controlled asthma with labetalol
0.5%
combined IV/IM admin of MgSO4: loading dose
4g MgSO4 IV in 100ml NS / 20 minute
+
5g IM into each buttock, every 4h
combined IV/IM admin of MgSO4: maintenance doses
5g IM into ONE buttock every 4h
signs of magnesium toxicity
- decreased or absent reflexes
- resp rate <12/min x 15 min
- O2 <94% x 15min
- low BP, low HR or arrhythmia
- urine <30ml x 4h
FH monitoring with MgSO4
<26/40 :
IA q30min
> 26/40 :
cCTG
MgSO4 - when do patellar reflexes disappear
10meQ
MgSO4 - when does respiratory depression occur
12meq
antidote for MgSO4
calcium gluconate 10%, 1 ampule (10ml) IV over 3 minutes
postpartum HTN accounts for up to ___% of all HDPs
25%
Placenta previa - risk factors for an increased risk of urgent/preterm C/S
Patient features
- APH <29/40 or >3 episodes
- previous CS
- short cx (<3cm PP, <2cm LLP)
Placental features
- thick placenta edge (>1cm)
- presence of a marginal sinus
- evidence of invasive placentation
dx of placenta prevue should be confirmed after ____wks
32/40
in women with LLP, USS should be used to confirm location prior to delivery - within last ____
7-14 days
C/S timing for PP
- in presence of RF’s 36-36+6
- in absence of RF’s 37-37+6
C/S timing for LLP (<=10mm)
- in presence of RFs 37 to 37+6
- in absence of RFs 38-38+6
LLP trial of labour recommended if
11-20mm from cervical os;
can be carefully selected women where placenta edge <10mm
incidence of PP
4-6/1000 pregnancies
RFs for PP
- AMA, multiparity
- previous c/s, PP
- chronic HTN, DM
- smoking, cocaine
- multiple gestation, ART
TV USS for PP dx, sensitivity and specificity
sen 88%
spec 99%
likelihood of resolution of LLP if dx made in 2nd trimester
> 98%
conditions under which PP is more likely to persist
if overlap >20-25mm at 18-23 weeks gestation;
40% of cases persisted
for PP/LLP, repeat USS at 36/40 if ?
if USS at 32/40 shows:
- placental edge <20mm,
- or with overlap <20mm
in PP, cx length associated with increased APH and PTB
<3cm (79 vs 38% APH)
and C/S 69% (vs 21%)
in LLP, cx length associated with increased APH and PTB
<2cm
APH in presence of PP is associated with contraction in ___% of women
33%
risk of APH in LLP <10mm
29%
risk of APH in LLP 11-20mm
3%
likelihood of a vaginal delivery in LLP <10mm
9-38%
likelihood of a vaginal delivery in LLP 11-20mm
57-93%
C/S Mat request for LLP 11-20mm timing
39-40+6
high risk of vasa previa
- low or velamentous cord insertion
- bilobate or succenturiate placenta
- PVB
vasa previa - timing of steroid admin
28-32 weeks
vasa previa - timing of hospitalization
30-32 weeks
reported incidence of vasa previa
1/1275 - 1/5000
incidence of vasa previa with velamentous cord insertion
1/50
incidence of vasa previa with ART/IVF
1/202 (LR 7.75)