Obs & Paeds Flashcards

1
Q

Obstetric critical care admissions

A

83% postnatal
Haemorrhage, sepsis, pre-eclampsia commonest
Antepartum - covid, respiratory failure

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2
Q

Fetal considerations in maternal critical care

A

monitoring
- obstetric and midwifery teams
- CTG / auscultation / dopplers as indicated
Delivery
- timing decided by MDT
- mother may benefit if intractable hypoxia
- lung maturation with steroids 24-34 weeks
resuscitation
- specialised equipment
teratogencity
- imaging risks
- drug risks 1st trimester

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3
Q

Risks of imaging

A

fetus maximum risk 10 - 17 weeks from ionising radiation (microcephaly, developmental delay)
iodine - fetal thyroid risk worse with age
mother CTPA - risk of breast cancer. V/Q increased risk to fetus

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4
Q

pharmacological concerns

A
  1. teratogenicity 1st trimester - AEDs, warfarin, ACE, antibiotics (trimethoprim, tetracyclines)
  2. Analgesics - NSAIDs - closure of DA, avoid after 30/40, codeine unreidvtable breastfeeding, opioids neonatal resp depression and withdrawal
  3. sedatives - depressant effect on fetus at delivery
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5
Q

Hypertensive disease in pregnancy

A

10% pregnancies
neonatal and maternal morbidity and mortality

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6
Q

gestation hypertension / PIH

A

> 140/90 after 20/40
- aim for < 135/85
- methyldopa
- labetalol
- nifedipine
- Ix for PET
160/110
- admit to hospital

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7
Q

PET

A

> 140 / 90
20/40
Organ dysfunction
- proteinuria (PCR > 30mg/mmol) / 2+
- creatinine > 90
- headache
- ALT 2x ULN
- platelets < 150
- IUGR

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8
Q

Severe PET features

A

> 160 / 110
Pulmonary oedema
Eclamptic seizures
RUQ pain
HELLP
platelet < 100
severe headache, visual disturbance

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9
Q

PET pathophysiogy

A

complex multi-system disease associated with endothelial dysfunction
abnormal placentation, relative placental hypoxia
- inflammatory factors
decrease proangiogenic (VEGF)
increase antiangiogenic
increased vascular tone and permeability

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10
Q

PET MX

A
  • BP control - methyldopa, labetalol, nifedipine
    • labetalol 200mg 12hrly increased to 2.4g/24hr
    • IV bolus 20mg then commence infusion
  • Aim for < 135/95
  • MgSo4 seizure or severe. 4g bolus then 1g/hr. tendon reflexes. toxicity - calcium.
  • MAGPIE - lower risk of eclampsia
  • consideration of invasive monitoring
  • monitoring for end organ complications - U+E / LFT / Coag studies
  • If severe –> delivery. dependent on gestation, severity
  • careful fluid balance (1ml/kg/hr)
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11
Q

PET Complications

A
  • eclamptic seizures
  • severe organ dysfunction - liver, renal, DIC
  • hypertensive emergencies - aortopathy, ACS, ICH
  • fluid leak - pulmonary oedema
  • fetal compromise - IUGR, death, preterm birth
  • PPH
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12
Q

PET admission to critical care

A
  • features of severe disease
  • pulm oedema requiring respiratory support
  • severe hypertension requiring IV
  • eclamptic seizures
  • strict fluid balance, severe ologuria
  • severe coagulopathy needing mx
  • Bleeding / PPH

considerations
- difficult airway
- hypertensive response to laryngoscopy
- risk of pulmonary oedema - restrictive balance, GTN

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13
Q

Major obstetric haemorrhage

A

9% perinatal deaths (50% worldwide)

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14
Q

Classification

A

Antepartum 24/40 - delivery
- abruption, praaevia, trauma, accreta, rupture
Postpartum
- primary - 24hrs
- secondary 24hrs-12 weeks - infection
- minor 500-1L
- major > 1L. moderate 1L-2L. severe > 2L

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15
Q

WHO maternal sepsis

A

life threatening organ dysfunction resulting from infection during pregnancy, childbirth, post-abortion or postpartum period

leading cause of maternal morbidity and mortality worldwide. UK 11% deaths.

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16
Q

Common causes maternal sepsis

A

Direct
- Genital tract infection - Group A strep
- endometritis - e.coli
indirect
- urinary tract infection
- respiratory
- meningitis
- covid

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17
Q

risk factors maternal sepsis

A

patient
- immunocompromise - medications, diabetes
- ivdu
- strep colonised
pregnancy / delivery related
- IUD
- pph
- instrumentation
- prolonged labour
- PROM
- retained products
- trauma
- c-section

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18
Q

Management priorities in maternal sepsis

A

prevention - vaccination, abx for instrumentation, management of PROM
cvs support - left lateral displacement fluid management
surgical source control - wound infection, ERPC, delivery of fetus

considerations re. delivery - source, severity, gestation age, fetal wellbeing, state of labour, parity

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19
Q

AFE

A

exposure of fetal antigens or amniotic fluid substances to maternal circulation leads to sudden catastrophic immune activation
2 phases
- initial entry of substances leads to pulmonary hypertension, RV failure, microvascular damage, hypotension
- LV failure, endothelial activation, capillary leak, DIC

high mortality, neurological injury

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20
Q

AFE presentation

A
  • fetal distress
  • sudden profound maternal collapse
  • cardiac arrest
  • hypotension
  • pulmonary oedema, ards, hypoxia
  • seizures
  • dic

clinical diagnosis, confirmation postmortem only

acute hypotension, cardiac arrest, hypoxia, coagulopathy, haemorrhage in absence of other explanation

DDX anaphylaxis, PE, MI, sepsis, LAST, major haemrrhage

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21
Q

risk factors for AFE

A

advanced age, eclampsia, multiple pregnancy, male fetus, induction, oxytopicin, c-section

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22
Q

Causes of maternal cardiac arrest

A

Hypoxia
- PE
- AFE
- Pulmonary oedema
Hypovolaemia
- Haemorrhage
- Sepsis
Hypo/hyperkalaemia
hypothermia rare
toxins - LAST
Tamponade: aortic dissection
Thrombosis: AFE, PE
Tension

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23
Q

Alterations in ALS for maternal cardiac arrest

A
  • left uterine displacement
  • perimortem cesarean - within 5 mins
    Specific drugs
  • MgSO4 for eclampsia
  • calcium for magnesium toxicitiy
  • thrombolysis
  • intralipid
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24
Q

MBRACCE 2019-21

A

Indirect causes
1. covid-19
2. Cardiac disease
3. Neurological
4. Sepsis
5. Psychiatric
Direct causes
1. Thrombosis
2. Haemorrhage
3. Psychiatric
4. Sepsis
5. PET
6. AFE

Direct = resulting from obstetric complications of the pregnant state, including interventions, omissions, treatment
Indirect = resulting from previous existing disease or disease that developed during pregnancy, not due to direct obstetric causes but aggravated by physiological changes of pregnancy

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25
bronchiolotis
respiratory infection, children under 2 (3-6mo) clinical diagnosis coryza, fever, wheeze, cough, crepitations varying respiratory failure DDx pneumonia, croup, asthma, viral wheeze Severe disease - FiO2 > 0.5 to maintain 95% - severe recessions - tachypnoea, tachycardia, apnoeas Life threatening - Sats < 88% despite HF / CPAP - respiratory acidosis - apnoeas requiring FMV, exhaustion, grunting
26
risk factors in bronchiolitis
- chronic lung disease - prematurity - cardiac comorbidity - < 6 weeks of age
27
Mx bronchiolotis
- clear nasal secretions - respiratory support - humidified O2, CPAP, BIPAP - hydration / NG feed - gastric decompression - invasive ventilation - deteriorating severe disease - respiratory acidosis, hypoxia on NIV ICU complciations - secondary bacterial infection - mucous plugging - bronchospasm - bradycardia - hyponatraemia
28
How might a child with congenital heart disease present to hospital?
- cardiac arrest - respiratory failure - shock - failure to thrive - cyanosis
29
Fontan circulation
single functional ventricle e.g. pulmonary atresia, hypo plastic left heart 4-12 mo cavopulmonary connection 5 year completion - IVC connection to PA
30
CHD presentations to intensivist
- severe cyanosis - TGA, pulmonary atresia, obstructed TAPVD - cardiac failure - left outflow obstruction.- severe AS, coarctation, hypo plastic left heart. may present when DA closes. cold pale weak pulses, hepatomegaly
31
Management principles in congenital heart disease
- reduce O2 demand - IPPV - correct acidosis, hypoxia, hypercarbia - prostaglandins for duct patency - inotropes - dw cardiac centre patients surviving to adulthood and may present to adult critical care.
32
Cyanotic lesions
Likely if PaO2 doesn't rise 20kPa after 10 mins 100% O2 obstruction to pulmonary flow - ToF, pulmonary stenosis Pulmonary and systemic circulations in parallel - TGA Complete mixing of systemic and pulmonary blood - single ventricle, truncus arteriosis pulmonary venous abnormalities - TAPR intubation and early prostaglandin
33
Non-cyanotic lesions
- septal defects - left --> right shunt - left sided obstruction - coarctation, AS lead to pulmonary oedema. systemic circulation from RV through DA.
34
Duct dependent lesions
Duct dependent pulmonary circulation - pulmonary atresia - pulmonary stenosis - tricuspid atresia - Severe ToF Duct dependent systemic circulation - Severe AS - Coarctation - Hypoplastic left heart Duct dependent pulmonary and systemic - Transposition of great arteries
35
Suspect duct dependent lesions when
cyanosis hypoxia despite O2 tachypnoea without lung pathology Pulmonary oedema, pathological murur, absent femoral pulse, hepatomegaly, cardiogmegaly, lactic acidosis 100% O2 may result in excess flow through the lungs - pulmonary overcirculation. aim for pre and post ductal saturations 75-85%. pink and shocked. balanced circulation - increase PVR or decrease SVR. avoid high O2, modest PEEP
36
prostaglandin side effects
apnoea ypertherthermia hypotension 5-100ng/kg/min. greater SE with high dose
37
DKA in children
HCO3 < 15 / pH < 7.30 Ketones > 3 Differences - first presentation of diabetes - susceptible to cerebral oedema - glucose falls rapidly with rehydration - withhold insulin 1-2 hrs start 0.05units/kg/hr - abdo pain common
38
Fluid management in paediatric DKA
shock - bolus 10ml/kg as needed if not shocked consider 10ml/kg over 60 mins replacement of deficit over 48hrs 0.9% + 20mmol KCL - severe DKA = 10% dehydration - mild-moderate = 5% Add deficit to maintenance maintenance fluid 10 / 50 / 20
39
cerebral oedema in DKA
early - headache, agitation, bradycardia, hypertension late - reduced GCS, abnormal breathing pattern, palsies, posturing 3ml/kg 3% saline 0.5g/kg mannitol reduce fluid
40
Neonatal life support
risks fetal - < 37/40, congenital abnormalitiy maternal - infection, PET, high BMI intrapartum - em CS, GA, bleeding, breech vaginal delivery meconium, fetal compromise
41
NLS algorithm
First 60s - delay cord clamping if possible - assess colour, tone, breathing, HR - open airway - 5 inflation breaths (30cmH20) if gasping / not breathing Ongoing - reassess - if no HR improvement look for chest movement - if no chest movement use 2 person airway control - repeat 5 breaths - ventilate for 30s if HR < 60 - chest compressions 3:1 if HR < 60. fiO2 1.0 - reassess every 30s 32/40 + air 28-31/40 0.21 - 0.3 < 28/40 - 0.3 preductal sats (right hand) 65 - 85 -90 2-5-10mins Bradycardia despite AB and CPR adrenaline IV 20mc/kg review at 10mins usually discontinue at 20mins
42
Therapeutic hypothermia
clinica, biochemical evidence of risk of hypoxic ischaemic encephalopathy - consider inducing hypothermia 33-34 degrees
43
Paediatric life support
5 rescue breaths 15:2 non-shockable - 10mcg/kg adrenaline shockable 4J/kg
44
Paediatric arrhythmias
decompensation - reduced LOC, tachypnoea, BP < 5 gentile, CRT > 2 bradycardia - oxygenate. if vagal 20mcg/kg atropine. if not 10mcg/kg adrenaline narrow complex tachycardia - sinus tachycardia infant 180-220, child 160-180. treat precipitant (sepsis, hypovolaemia, pain) - SVT infant > 220 child > 180 - adenosine 100-150mcg/kg, DCCV 1j/kg broad complex tachycardia - if conscious - sedate and DCCV - unconscious - DCCV - 2--> 4 j/k. amiodarone 5mg/kg before 3rd
45
Paediatric sepsis definition
life threatening organ dysfunction caused by dysregulated host response to infection - severe sepsis 2 + SIRS criteria, confirmed or suspected invasive infection, cvs dysfunction, ARDS or 2+ other organ system dysfunction - septic shock - severe infection leading to cvs hypotension, vasoactive medication, impaired perfusion
46
Paediatric SIRS
2 or more 1 must be abnormal temp or abnormal WCC - temp > 38.5 or < 36 - WCC > 34 ---> 11 1w ---> 17 - HR > 2SD above normal (180 up to 1yr, 140 2-5, 130 6-12, 11 13-17 - RR > 2SD above normal
47
Paediatric organ dysfunction
resp - P/F < 300 - need for invasive or non-invasive ventilation CVS - despite 40ml/kg isotonic crystalloid - hypotension BP < 2SD below normal - vasoactive support - acidosis, lactataemia, oliguria, CRT > 5s, core to peripheral temperature differential 3 degrees Neuro - GCS < 11 renal - creatininee > 2x ULN Hepatic - bili > 4mg/dl (68) haem - platelets < 80, INR > 2
48
Other DDX in neonatal collapse
- cardiac - trauma (NAI) - metabolic - surgical
49
Resusctivative measures in paediatric sepsis
- source control - 40-60ml/kg fluid in 1st hour if shock or organ dysfunction - adrenaline, NA first line vasoactive - IV hydrocortisone in refractory instability Extracorporeal support - RRT - fluid overload - VV-ECMO severe pARDS - VA-ECMO - refractory shock
50
Commonest injuries causing death in paediatrics
- RTC - fall from height - drowning - burns - poisoning
51
Injury prevention
Primary - speed limits, cycle lanes, child resistant medication containers Secondary - seat belts, bike helmets Tertiary - pressure to laceration, cold water to burns
52
Consideration of child injury patterns
Chest - elastic tissues - high degree of force to fracture rib. - contusions common Abdomen - liver, spleen, bladder all more exposed - less protection Neuro - single biggest cause of trauma death - fontanelles / sutures may mitigate ICP rise - prone to cerebral oedema Limbs / spine - extremity injury common but less likely to be life threatening - pelvic fractures uncommon - spinal cord injury in absence of fracture
53
Presentations related to NAI
- head injuries - long bone fractures, multiple - ruptured viscus - glove and stocking burns - suffocation - bruising in non-mobile infant, non-exposed areas
54
Doses of resuscitative agents in paediatric trauma
- blood - 5ml/kg - TXA - 15mg/kg - crystalloid 10ml/kg - 20ml/kg blood --> 10ml/kg platelets - 0.1ml/kg 10% calcium chloride transfusion targets - platelets 50 - fibrinogen 1 - ica 1 - hb 80-120
55
GCS in children
< 4 - children's GCS E / M same as adult V 5 - babbles, coos, alert to normal level 4 - less than usual words, irritable cry 3 - cries only to pain 2 - moans to pain 1 - nil to pain preverbal - grimace response
56
NICE paediatric CT head
- GCS < 14 initial (< 15 if under 1) - GCS < 15 at 2hrs - suspected NAI - seizure in absence of epilepsy - suspected BOS fracture - focal neurology - suspected open / depressed fracture - < 1 with > 5cm bruise, swelling, laceration
57
paediatric inflammatory conditions
- sepsis - toxic-shock - HLH - MAS - Kawasaki disease - PIMS-TS (paediatric multisystem inflammatory syndrome temporally associated with Sars Cov-2
58
PIMS-TS
fever, oxygen requirement, hypotension others - mucous membrane changes - lymphednopathy - syncope - confusion - gi upset High fibrinogen, CRP, d-dimer, ferritin low albumin, lymphocytes CXR - patchy infiltrates Echo - myocarditis, valvulitis Management - treat as covid-19 - evaluate cardiac dysfunction - empirical abx - immunomodulation on discussion with MDT - IVIG if Kawasaki disease criteria fulfilled
59
Toxic shock syndrome
acute inflammatory multi system condition associated with exotoxin production from gram positive infections. early shock, rash, desquamation, fever
60
TSS causes
Group A strep - strep progenies (burns, new fas) (TSLS) Staph aureus - menstrual products, nasal packs, IUD, pneumonia
61
TSS presentaiton
fever, malaise, rash circulatory compromise myocarditis abdo pain
62
TSS Ix
Blood cultures MC/S any fluid usual bloods urine - haemoglobinuria cxr - ards staphylococcal antibody, streptococcal exotoxin
63
TSS diagnosis
Probable: clinical case definition + isolation of GAS from non sterile site confirmed : GAS from sterile site clinical case definition - hypotension - 2+ organ involvement - renal, haem, liver, ards, generalised rash, soft tissue necrosis Non-strep - clinical + lab criteria - lab includes negative cultures (apart from SA) negative serology for rocky mountain fever, lepto, measles
64
TSS Mx
source control - debridement - antimicrobials + antitoxin - ivig in streptococcal - supportive care
65
Paediatric DKA
Diagnosis same as adults severity pH < 7.1 - severe (10% dehydration) pH < 7.2 - moderate (5% dehydration) pH < 7.3 - mild (5% dehydration) deaths - cerebral oedema - hypokalaemia - inadequate fluid replacement - aspiration pneumonia
66
Fluid in Paediatric DKA
Shocked - 10ml/kg bolus, repeat as needed not shocked 10ml/kg over 30 mins requirement = deficit + maintenance maintenance = 100 / 50 / 20 deficit = according to severity 5 / 5/ 10%. replaced over 48 hours n/saline + 40mmol KcL switch to 5% dextrose when BM < 14
67
Insulin in paediatric DKA
- start 1-2 hours after fluid - 0.05 - 0.1 units/kg/hr - reduce rate when BM < 14
68
Cerebral oedema in paediatric DKA
headache / agitation / fall in HR / rise in BP deterioration in consciousness, posturing, pupillary changes, breathing abnormalities - 2.5ml/kg 3% saline or 0.5g/kg mannitol 20% - fluid 1/2 maintenance