End of life Flashcards

1
Q

prognostication

A

process of predicting what a patients outcome is likely to be
- admission decisions
- treatment limitations - IPPV, RRT, extracorporeal life support
- tracheostomy
- invasive procedures
- withdrawal of life sustaining treatments

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2
Q

post cardiac arrest

A

OOH - < 10% survive to hospital discharge
in hospital - 25% survive to hospital discharge
Resus council - 72 hrsunconscious, GCS motor score 3 or less. 2 of
- absent pupillary light reflex
- Adverse CT/MRI (anoxic injury)
- Absent SSEPs
- Status myoclonus
- malignant EEG
- NSE > 60

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3
Q

Neurological outcome after brain injury

A

cerebral perfomance category
1 - good
2 - moderate disability independent
3 - severe disability (ambulant –> paralysis) conscious but dependent
4. coma or vegetative state (any impaired consciousness without brain death)
5. brain death

Modified rankin scale
0 - no symptoms
1 - symptoms but no disability - all ADLs
2 - mild disability - not all ADLs
3 - mod disability - help, walks without assistance
4 - mod severe disability - assistance to walk and bodily needs)
5 - severe disability - bed bound
6 - dead

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4
Q

frailty

A

Clinically recognisable state of vulnerability resulting from age related decline in reserve and function across multiple physiological systems such that ability to cope with everyday or acute stressors is compromised

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5
Q

performance status

A

initially used to assess patients independence in the context of malignancy
0 - fully active
1 - restricted strenuous activity
2 - ambulatory, self caring, unable to carry out work activities
3 - limited self care, confined to chair or bed 50%
4 - completely disabled confined to bed or chair
5 - dead

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6
Q

palliative care

A

holistic care of patients with advanced progressive incurable illness, to support patients to live well until they die
focus on symptom management and psychological, spiritual, social support

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7
Q

end of life

A

patients approaching end of life when it is likely they will die in the next 12 months
end stage is fine; period of progressive disease

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8
Q

futility

A

perceived non-benefit of treatment
- physiological - unable to maintain acceptable physiology
- quanititative - low chance of succeeding
-qualitative - cannot achieve acceptable QoLec

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9
Q

principles of EOL decision making

A

equalities
human rights
presumption in favour of preserving life
presumption of capacity
overall benefit

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10
Q

decision making for adults without capcaity

A
  • be clear what decisions must be made
  • check of legally binding advance decisions
  • enquire whether someone holds legal authority to decide
  • take responsibility for deciding which treatment will provide overall benefit, consulting’sg those close to patient

role of family
- provide information about patients wishes, preferences, feelings, beliefs and values
- don’t make decisions
- unless they have legal authority to make decisions on behalf of the patient who lacks capacity

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11
Q

disagreement about decisions surrounding EOLC

A
  • seek advice from colleagues
  • independent advocate
  • case conference or ethics consultaion
  • mediation services
  • legal advice, independent court ruling
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12
Q

principles of withdrawing care

A
  • not to prolong death, relieve symptoms and maintain dignity
  • likely procedures involved e.g. extubation
  • uncertainty about dying process, amount of time
  • support
  • how symptoms will be managed
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13
Q

withdrawing organ support

A
  • individualised assessment
  • stop non-comfort medications
  • stop monitoring
  • assess relevant symptoms
  • sequential reduction in support - vasoactive medications, ventilatory support, extubation

special circumstances
- status epilepticus - continuing sedation
- NIV - weaning support and O2 to air
- MCS / ECMO - reduction in pump and gas flow
- ICD - deactivation

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14
Q

consequences of death for the individual

A
  • cessation of resuscitation efforts
  • religious ceremonies
  • execution of will
  • post mortem examination
  • registration and certification of death
  • organ donation
  • disposition of body
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15
Q

somatic criteria for death

A

general recognition of death by another person (recognition of life extinct criteria)
- decapitation
- massive cranial disruption
- hemicorporectomy
- incineration
- decomposition / putrefaction
- rigor mortis

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16
Q

cardiorespiratory criteria for death

A

loss of consciousness
continuous apnoea and asystole
- cessation of circulation - absent pulse, absent heart sounds
- cessation of respiratory system - absent respiratory effort, no breath sounds
- cessation of cerebral function (5 mins after above) - fixed dilated pupils, no corneal reflex, no motor response to pain

17
Q

time of death

A

at time of verification of life extinct
1st set of tests in brainstem death

18
Q

37/ 40 - 2 months VLE

A

no heart sounds
no respiratory effort or breath sounds
no spontaneous movement or response to stimulation

19
Q

medical examiner

A

provides scrutiny of all deaths
provide support for bereaved
improve quality of death certification and mortality data

20
Q

coroner

A

independent judicial officer responsible for investigating a patients cause of death in certain circumstances
- who
- how, when, where death occurred
- may involve post mortem or inquest
clinical team responsible for referring appropriate cases

21
Q

indictions for referral to coroner

A
  • mechanism - unnatural trauma, self harm, neglect, poisoning, notifiable accidents/diseases, anaesthesia, post-operative
  • unknown cause of death
  • unknown patient
  • patient in custody or state detention
22
Q

coroner conclusions

A
  • natural causes
  • misadventure
  • suicide
  • unlawful killing
  • lawful killing (self defence)
  • industrial disease
  • narrative - described circumstances but not bound by above
23
Q

last offices

A

historical term used to describe care after death
- spiritual / cultural wishes
- preparing body for transfer to mortuary
- privacy, dignity
- honouring wishes for organ and tissue donation
if coronial involvement - leave all lines, keep infusions attached but clamped, do not wash or begin mouth care
no coronial - mouth care, tidy, clean, dress

24
Q

Diagnosing death by neurological criteria

A
  1. Evidence of irreversible brain injury of known aetiology
  2. exclusion of reversible causes of coma and apnoea
  3. examination of absent brainstem function
25
Q

DND

A

preconditions
- brain injury known aetiology
- GCS 3 requiring mechanical ventilation
causes
- intracranial - haemorrhage, TBI, ischaemic stroke
- extra cranial - profound hypoxia
exclusion of reversible causes of apnea and coma
- CVS instability
- PaO2 > 10, PaCO2 < 6, MAP > 60, pH 7.35-45
- drugs
- sedatives, NMB
- reversal agents if needed
- Metabolic
- temp > 34
- Na 115 - 160
- K > 2
- glucose 3-20
- Po4 / Mg 0.5 - 3
- Endocrine - if doubt levels to be taken

26
Q

red flags DND

A
  • within 6 hours of loss of last reflex
  • within 24 hours if cause is anoxic damage
  • within 24 hours if rewarming
  • neuromuscular disorders
  • prolonged fentanyl infusions
  • decompressive craniectomy
  • steroids in SOL
  • posterior fossa or brainstem pathology
  • therapeutic decompressive craniectomy
27
Q

Brain stem testing

A

Afferent / efferent
- pupillary light response - II, III
- corneal reflex - V / VII
- supra-orbitals pressure - V / VII
- vestibulochlear - VIII, III, VI
- Gag - IX, X
- Cough - IX, X

28
Q

Apnoea test

A

baseline ABG
Adjust ventilation to ensure - pH < 7.4 pCO2 > 6
repeat ABG
PreO2
disconnect from ventilator and maintain oxygenation with waters circuit
observe for 5 mins for any ventilation
if none, repeat abg
PCO2 > 0.5 rise

29
Q

DND challenging

A

extensive facial injury - unable to perform cranial nerve examination
high cervical spine injury - aetiology of apnoea

ancillary testing - CT angiography

30
Q

critical care management of brain stem dead organ donor

A

important as average donates 3.3 organs
standardised mx improves organ retrieval
challenges
- cvs instability
- DI
- Neurogenic pulmonary oedmea
- electrolyte disturbance
- DIC
- hypothermia

31
Q

immediate objectives in care of heart beating organ donor

A
  • methylprednislone
  • identify and treat DI
  • switch NA to vasopressin
  • correct hypovolaemia
  • glycemic control
  • stop unnecessary medications
    physiological targets
  • pO2 > 10
  • pH > 7.25
  • MAP 60-80
  • UO 0.5-2
  • Na < 150
  • glucose 4-10
  • normothermia
32
Q

specific optimisation

A

respiratory
- LPV
- recruitment maneouvres
- tracheal suctioning / physio
- consider bronchoscopy and lavage
cvs
- correct hypovaolaeia
- CO monitoring
VP 0.5-4units/hr
fluids.metabolic
- 15mg/kg methylprednisolone
- NH water if hypernatraemia
- UO > 4ml/kg/hr give DDAVP
- LMWH

33
Q

DCD Maastricht criteria

A

controlled donor = retrieval after expected death (III, IV)
uncontrolled = after unexpected and irreversible cardiac arrest (I, II, V)
I - dead on arrival
II - unsuccessful resuscitation
III - anticipated cardiac arrest
IV - cardiac arrest in brain dead donor
V - unexpected arrest in ICU patient

34
Q

DCD limitations

A

eligbilility
containdications
- age > 85
- CJD
- viral haemorrhage fever
- TB
- active cancer generally
- HIV generlaly
susceptibility of organs to warm ischaemia

35
Q

stages of DCD

A
  • decision to withdraw active treatment
  • screening of suitability for DCD
  • conset for DCD
  • withdrawal ( theatre)
  • palliative care
  • diagnosis of death circulatory criteria
  • retrieval
  • last offices
36
Q

ischaemic time

A
  • ischaemic organ injury and influence outcome of graft
    functional warm ischaemic time
  • starts when sBP < 50 or SaO2 < 70%
  • ends when cold perfusion takes place
    graft cold ischaemia
  • starts at cold perfusion
  • ends at removal from cold storage
    graft warm ischaemic time
  • starts at removal from cold storage
  • ends at reperfusion

Suggested max functional warm ischaemic time
- liver 30 mins
- pancreas 30 mins
- lung 60 mins
- kidney 120 mins

37
Q

ex vivo perfusion

A

machine perfusion to improve viability of organs
dcd heart / kidneys
in vivo technique - thoracic and abdominal organs perfused in situ after cerebral circulation isolated
dcd lungs - tracheal intubation after confirmation of death. single recruitment manoeuvre > 10 mins after systole followed by CPAP 5cmh20