Obs and Gynae Flashcards
what causes stress incontinence?
weakened urethral sphincter muscles mean that the detrusor pressure > urethral closing pressure which causes leakage when coughing and exervising
RF for stress incontinence
menopause, vaginal births, congenital weakness, pelvic surgery
How do you investigate urinary incontinence?
Urine stix - exclude UTI freq/vol chart - functional capacity of the bladder urodynamics QoL questionaire vaginal exam
how do you manage stress incontinence?
- Conservative - 3 months of pelvic floor exercises, lose weight, stop smoking, treat a cough and constipation
- peri-urethral bulking agents
Medication: Duloxetine
what causes overactive bladder?
overactive detrusor muscle
what are the RF for an overactive bladder?
MS/neurological/incontinence surgery/increasing age
what provokes symptoms of an overactive bladder?
provoked by cold weather, opening the front door, coughing and sneezing
how do you manage an overactive bladder? what are the side effects of the first line medical treatment
- Lifestyle - avoid excess fluids, caffeine, carbonated drinks, alcohol
1st line = oxybutynin (anti muscarinic) - relaxes the detrusor by blocking the parasym - SE = dry mouth/constipation/nausea
2nd line = mirabegron (B3 agonist)
3rd line = botox injection
what is a prolapse?
protrusion of organs into the vagina due to weaened pelvic floor
Features of a prolapse (retrocele/cystocele)?
dragging sensation
Cystocele - urinary frequency/urgency/incomplete emptying
Retrocele - constipation/difficulty defacating
what are the RF for a vaginal prolapse?
prolonged labour, trauma and surgery to the pelvic floor, forcep delivery, chronic cough, obesity, high BMI
How do you investigate a prolapse?
clench test
bimanual examination
How do you manage a prolapse?
- pelvic floor exercises, lose weight, treat cough, stop smoking
- pessary (SE - discharge)
- surgical repair
what does LH do?
binds to theca cells which stimulates production of androgens
induces ovulation
what does FSH do?
binds to granulosa cells and converts androgens to oestrogen, and stimulates the production of inhibin
what are primary and secondary amenorrhea?
primary - no period by the age of 16
secondary - periods stop for >6 months in women with a previous regular cycle
Name some causes for primary amenorrhea?
congenital malformation of organs
Turner’s syndrome
familial
androgen insensitivity
what is Turner’s syndrome? what are the signs?
45X Coarction of aorta spade shaped chest - wide nipples and neck horseshoe kidney primary amenorrhea
what is androgen insensitivity syndrome?
peripheral insensitivity to testosterone despite having genotype 46XY - female phenotype but genetically male
name some causes of secondary ameonrrhea?
thyrotoxicosis PCOS Asherman's syndrome Sheeshan's syndrome prolactinoma hypothalamic
what is asherman’s syndrome?
scarred uterus from D&C - blood can’t leave uterus due to the scarring
what is sheeshan’s syndrome?
ischaemic damage to AP (panhypopituitarism)
name some causes of raised prolactin? what are the signs?
prolactinoma, antipsychotics (2nd generation)
galactorrhea, reduced libido, amenorrhea
how do you investigate amenorrhea?
bHCG, oestrogen, progesterone
FSH and LH levels
testosterone
what is menarche? when do you investigate?
first period - need to investigate if not started by 16. also investigate if no other sex characteristics by the age of 14.
what is the normal order of sexual development in a female?
- breast buds
- pubic hair
- axillary hair
- menses
what is the role of oestrogen?
prepares endometrium for implantation. Keeps the cervical mucus thin which is good for the sperm
what is the role of progesterone?
maintains the endometrium and creates a hostile environment to prevent more sperm entering the uterus.
what is dysmenorrhea?
painful periods with/without N&V.
how can you manage dysmenorrhea?
Mefenamic acid (NSAID) Tranexamic acid (if heavy bleeding) COCP - suppresses ovulation
name some causes of dysmenorrhea?
endometriosis, adenomyosis, fibroids, polyp
what is endometriosis?
endometrial tissue is present outside of the uterus. Disease driven by oestrogen.
RETROGRADE MENSTRUATION THEORY
what is the presentation of endometriosis?
cyclical pain with menstrual cycle severe dysmenorrhea adhesions deep dyspareunia dysuria, dyschezia reduced fertility
what do you find on examination of an endometriosis patient?
fixed and retroverted uterus
uterosacral masses on ligament
cervical excitation
Ix for endometriosis?
TVUS/MRI
CA125
gold standard = laparoscopy
how can you manage a patient with endometriosis who wants to get pregnant?
Mefenamic acid, tranexamic acid
Name some treatments for endometriosis?
- COCP + paracetamol
- Mirena IUS
- GnRH analogue (Goserelin)
- surgical ablation of endometriosis lesions
name some complications of endometriosis?
subfertility, adhesions, chocolate cysts
what is a fibroid?
benign tissue of smooth muscle of the myometrium (oestrogen dependant)
how do fibroids present?
menorrhagia
subfertility (submucosal)
pain
mass effect on bladder/bowel
How do you investigate fibroids?
TVUS
histeroscopy + biopsy
how do you manage fibroids?
<3cm - Mirena coil
other: GnRH analogue, myomectomy, uterine artery embolisation
name complications of fibroids?
subfertility
red degeneration
what is FGM?
any cutting/removal to external female genitalia - ILLEGAL IN THE UK
Acute and chronic effects of FGM?
ACUTE - blood loss, death, sepsis, pain, urinary retention
CHRONIC - dyspareunia, apareunia, UTIs, urinary retention
name some physiological ovarian cysts?
follicular corpus luteal
name some pathological ovarian cysts?
dermatoid (mature teratoma)
mucinous
chocolate cysts
how do ovarian cysts present?
asymptomatic chronic pain/dull ache/cyclical pain ACUTE - torsion irregular bleeding mass/ascites
IX for a ovarian cyst?
FBC, CA125, hCG, CEA
TVUS
MRI
what are the features of lichen sclerosis?
hourglass distribution of pearly white areas on the labia minora and the clitoris + regression of this tissue
ITCHY!
What is the definition of menopause?
<50 years - no periods for 24 months
>50 years - no period for 12 months
what are the features of the menopause?
menstrual irregularity
vasomotor - night sweats, hot flushes, palpatations
atrophy of genitalia and breasts
osteoporosis
How do you manage the menopause?
diet and exercise oestrogen cream for atrophic vaginitis SSRI for hot flushes HRT bisphosphonates for osteoporosis
what do you use for HRT if the woman has a uterus?
opposed oestrogen
name some contradictions of HRT?
oestrogen dependant cancer, undiagnosed PV bleed, previous PE
name some side effects of HRT?
fluid retention, bloating, acne, tender breasts
what annual checks do you do on a patient
BP, weight, breasts, PV bleeding
Risks of HRT?
increased risk of Breast cancer, VTE, stroke, MI
what is PID? name some causes
upper genital tract infection
chlamydia, gonorrhea, uterine instrumentation, IUCD
how does PID present?
abdo pain, dyspareunia, vaginal discharge
how do you investigate PID?
STI triple swab check
FBC/CRP/blood cultures
name some complications of PID?
Fitz hugh curtis syndrome
recurrent/chronic PID
abscess
subfertility and ectopic pregnancies
how do you treat PID?
ceftriaxone, azithromycin, doxycycline
what is PCOS criteria? what does it include?
ROTTERDAM CRITERIA
hyperandrogenism
oligomenorrhea
PCO > 12 on US
signs of PCOS?
subfertility, oligomenorrhea, hirtuism, acne, obesity, hyperinsulinaemia, acanthosis nigricans
how do you Ix PCOS?
TVUS LH and FSH - high LH:FSH ratio testosterone raised prolactin CA125 TFT glucose tolerance test
how do you manage PCOS?
GENERAL - weight loss, stop smoking, dietary advice
metformin - for increased insulin sensitvity
clomifene - induces ovulation
COCP - regulates cycle
cyroproterone - cream for hirsutism
what does PCOS increase the risk of?
endometrial cancer, T2DM, gestational diabetes
main feature of endometrial cancer?
POST MENOPAUSAL BLEEDING!
RF for endometrial cancer?
high BMI, post menopausal, HTN, PCOS, nullparity, late menopause, oestrogen only HRT, HNPCC
how do you investigate endometrial cancer?
TVUS - endometrial thickness >4?
hysteroscopy and biopsy –> FIGO staging