Obs and Gynae Flashcards
what causes stress incontinence?
weakened urethral sphincter muscles mean that the detrusor pressure > urethral closing pressure which causes leakage when coughing and exervising
RF for stress incontinence
menopause, vaginal births, congenital weakness, pelvic surgery
How do you investigate urinary incontinence?
Urine stix - exclude UTI freq/vol chart - functional capacity of the bladder urodynamics QoL questionaire vaginal exam
how do you manage stress incontinence?
- Conservative - 3 months of pelvic floor exercises, lose weight, stop smoking, treat a cough and constipation
- peri-urethral bulking agents
Medication: Duloxetine
what causes overactive bladder?
overactive detrusor muscle
what are the RF for an overactive bladder?
MS/neurological/incontinence surgery/increasing age
what provokes symptoms of an overactive bladder?
provoked by cold weather, opening the front door, coughing and sneezing
how do you manage an overactive bladder? what are the side effects of the first line medical treatment
- Lifestyle - avoid excess fluids, caffeine, carbonated drinks, alcohol
1st line = oxybutynin (anti muscarinic) - relaxes the detrusor by blocking the parasym - SE = dry mouth/constipation/nausea
2nd line = mirabegron (B3 agonist)
3rd line = botox injection
what is a prolapse?
protrusion of organs into the vagina due to weaened pelvic floor
Features of a prolapse (retrocele/cystocele)?
dragging sensation
Cystocele - urinary frequency/urgency/incomplete emptying
Retrocele - constipation/difficulty defacating
what are the RF for a vaginal prolapse?
prolonged labour, trauma and surgery to the pelvic floor, forcep delivery, chronic cough, obesity, high BMI
How do you investigate a prolapse?
clench test
bimanual examination
How do you manage a prolapse?
- pelvic floor exercises, lose weight, treat cough, stop smoking
- pessary (SE - discharge)
- surgical repair
what does LH do?
binds to theca cells which stimulates production of androgens
induces ovulation
what does FSH do?
binds to granulosa cells and converts androgens to oestrogen, and stimulates the production of inhibin
what are primary and secondary amenorrhea?
primary - no period by the age of 16
secondary - periods stop for >6 months in women with a previous regular cycle
Name some causes for primary amenorrhea?
congenital malformation of organs
Turner’s syndrome
familial
androgen insensitivity
what is Turner’s syndrome? what are the signs?
45X Coarction of aorta spade shaped chest - wide nipples and neck horseshoe kidney primary amenorrhea
what is androgen insensitivity syndrome?
peripheral insensitivity to testosterone despite having genotype 46XY - female phenotype but genetically male
name some causes of secondary ameonrrhea?
thyrotoxicosis PCOS Asherman's syndrome Sheeshan's syndrome prolactinoma hypothalamic
what is asherman’s syndrome?
scarred uterus from D&C - blood can’t leave uterus due to the scarring
what is sheeshan’s syndrome?
ischaemic damage to AP (panhypopituitarism)
name some causes of raised prolactin? what are the signs?
prolactinoma, antipsychotics (2nd generation)
galactorrhea, reduced libido, amenorrhea
how do you investigate amenorrhea?
bHCG, oestrogen, progesterone
FSH and LH levels
testosterone
what is menarche? when do you investigate?
first period - need to investigate if not started by 16. also investigate if no other sex characteristics by the age of 14.
what is the normal order of sexual development in a female?
- breast buds
- pubic hair
- axillary hair
- menses
what is the role of oestrogen?
prepares endometrium for implantation. Keeps the cervical mucus thin which is good for the sperm
what is the role of progesterone?
maintains the endometrium and creates a hostile environment to prevent more sperm entering the uterus.
what is dysmenorrhea?
painful periods with/without N&V.
how can you manage dysmenorrhea?
Mefenamic acid (NSAID) Tranexamic acid (if heavy bleeding) COCP - suppresses ovulation
name some causes of dysmenorrhea?
endometriosis, adenomyosis, fibroids, polyp
what is endometriosis?
endometrial tissue is present outside of the uterus. Disease driven by oestrogen.
RETROGRADE MENSTRUATION THEORY
what is the presentation of endometriosis?
cyclical pain with menstrual cycle severe dysmenorrhea adhesions deep dyspareunia dysuria, dyschezia reduced fertility
what do you find on examination of an endometriosis patient?
fixed and retroverted uterus
uterosacral masses on ligament
cervical excitation
Ix for endometriosis?
TVUS/MRI
CA125
gold standard = laparoscopy
how can you manage a patient with endometriosis who wants to get pregnant?
Mefenamic acid, tranexamic acid
Name some treatments for endometriosis?
- COCP + paracetamol
- Mirena IUS
- GnRH analogue (Goserelin)
- surgical ablation of endometriosis lesions
name some complications of endometriosis?
subfertility, adhesions, chocolate cysts
what is a fibroid?
benign tissue of smooth muscle of the myometrium (oestrogen dependant)
how do fibroids present?
menorrhagia
subfertility (submucosal)
pain
mass effect on bladder/bowel
How do you investigate fibroids?
TVUS
histeroscopy + biopsy
how do you manage fibroids?
<3cm - Mirena coil
other: GnRH analogue, myomectomy, uterine artery embolisation
name complications of fibroids?
subfertility
red degeneration
what is FGM?
any cutting/removal to external female genitalia - ILLEGAL IN THE UK
Acute and chronic effects of FGM?
ACUTE - blood loss, death, sepsis, pain, urinary retention
CHRONIC - dyspareunia, apareunia, UTIs, urinary retention
name some physiological ovarian cysts?
follicular corpus luteal
name some pathological ovarian cysts?
dermatoid (mature teratoma)
mucinous
chocolate cysts
how do ovarian cysts present?
asymptomatic chronic pain/dull ache/cyclical pain ACUTE - torsion irregular bleeding mass/ascites
IX for a ovarian cyst?
FBC, CA125, hCG, CEA
TVUS
MRI
what are the features of lichen sclerosis?
hourglass distribution of pearly white areas on the labia minora and the clitoris + regression of this tissue
ITCHY!
What is the definition of menopause?
<50 years - no periods for 24 months
>50 years - no period for 12 months
what are the features of the menopause?
menstrual irregularity
vasomotor - night sweats, hot flushes, palpatations
atrophy of genitalia and breasts
osteoporosis
How do you manage the menopause?
diet and exercise oestrogen cream for atrophic vaginitis SSRI for hot flushes HRT bisphosphonates for osteoporosis
what do you use for HRT if the woman has a uterus?
opposed oestrogen
name some contradictions of HRT?
oestrogen dependant cancer, undiagnosed PV bleed, previous PE
name some side effects of HRT?
fluid retention, bloating, acne, tender breasts
what annual checks do you do on a patient
BP, weight, breasts, PV bleeding
Risks of HRT?
increased risk of Breast cancer, VTE, stroke, MI
what is PID? name some causes
upper genital tract infection
chlamydia, gonorrhea, uterine instrumentation, IUCD
how does PID present?
abdo pain, dyspareunia, vaginal discharge
how do you investigate PID?
STI triple swab check
FBC/CRP/blood cultures
name some complications of PID?
Fitz hugh curtis syndrome
recurrent/chronic PID
abscess
subfertility and ectopic pregnancies
how do you treat PID?
ceftriaxone, azithromycin, doxycycline
what is PCOS criteria? what does it include?
ROTTERDAM CRITERIA
hyperandrogenism
oligomenorrhea
PCO > 12 on US
signs of PCOS?
subfertility, oligomenorrhea, hirtuism, acne, obesity, hyperinsulinaemia, acanthosis nigricans
how do you Ix PCOS?
TVUS LH and FSH - high LH:FSH ratio testosterone raised prolactin CA125 TFT glucose tolerance test
how do you manage PCOS?
GENERAL - weight loss, stop smoking, dietary advice
metformin - for increased insulin sensitvity
clomifene - induces ovulation
COCP - regulates cycle
cyroproterone - cream for hirsutism
what does PCOS increase the risk of?
endometrial cancer, T2DM, gestational diabetes
main feature of endometrial cancer?
POST MENOPAUSAL BLEEDING!
RF for endometrial cancer?
high BMI, post menopausal, HTN, PCOS, nullparity, late menopause, oestrogen only HRT, HNPCC
how do you investigate endometrial cancer?
TVUS - endometrial thickness >4?
hysteroscopy and biopsy –> FIGO staging
what is the commonest type of ovarian cancer?
serous cell
what is cervical screening looking for?
CIN (levels of dykaryosis)
what happens with the results of cervical screening?
BORDERLINE/MOD –> Test for HPV –> +ve –> colposcopy
MOD –> colposcopy
who do we screen for cervical cancer?
25-50 screen 3 yearly
50-70 screen 5 yearly
how do you manage CIN?
loop diathermy
symptoms of cervical cancer?
post-coital and intermenstrual bleeding, discharge, pain, ureteric and bowel disruption
what would you find on examination of a patient with cervical cancer?
irregular cervix surface, increased acetic acid uptake, rough and hard cervix, abnormal vessels
what causes thrush? symptoms? Ix? management?
cause: candida albicans
signs: cottage white cheese discharge, fissures, pain and itch
Ix: MC&S, micella and spores
Mx: topical clotrimazole or oral fluconazole
what causes trinchomonas? symptoms? Ix? management?
trinchomonas vaginalis
signs: strawberry cervix, thin fishy discharge
wet film: motile flagellates
Mx: metronidazole and contact trace
what causes BV? symptoms? Ix? management?
gardenerella vaginalis
signs: fishy discharge, large vol, pH>4.5, positive whiff test (add KOH and there is an ammonia smell)
clue cells on microscopy
Mx: metronidazole
what causes gonorrhea? symptoms? Ix? management?
neisseria gonorrhea
pres: abdo pain, discharge, post-coital bleeding
Ix: swab –> NAAT –> sensitivities
Mx = Ceftriaxone + azithromycin
what causes chlamydia? symptoms? Ix? management?
symptoms: dysuria, discharge, post coital bleeding
Ix: swab –> NAAT
Mx: azithromycin + contact trace
name some complications of chlamydia?
PID, fitz hugh curtis syndrome, Reiters
what strains of HPV cause genital warts?
6 and 11
who do we screen for breast cancer?
women aged 50-70 every 3 years with the mammogram
commonest type of breast cancer?
invasive ductal carcinoma
what are the RF for breast cancer?
BRCA 1/2, 1st degree
who do you refer to a breast specialist?
> 30 - woman with lump/pain
>50 - nipple dischrge/retraction/abnormal changes
how do we medically treat breast cancer? different age groups and their actions
pre-menopause - Tamoxifen (selective oestrogen receptor modulator)
post menopausal - aromatase inhibitor (anastrazole)
HER2 +ve - Herceptin
Surgeries used for breast cancer?
mastectomy, wide local excision, radiotherapy, chemo, immune checkpoint inhibitors
SE of tamoxifen?
increasd risk of VTE/EC/hot flushes/PV bleeding/amenorrhea
name some benign breast lesions
fibroadenoma
cysts
Discuss the development of the placenta?
develops from trophoblastic cells which invade spiral arteries and form sinuses. Villi form at 6 weeks and forms the functional placenta units –>placenta continues to grow until 16 weeks
what are the functions of the placenta?
gas exchange, produces hCG/GF/oestrogen/progesterone, barrier to infection/drugs, nutrient transfer.
what physiological changes are there during pregnancy?
HAEM - increased blood volume - produces physiological anaemia
CVS - increases in CO/SV, reduced peripheral resistance, varicose veins
VENTILATION - increases by 40%
reduced gut motility due to progesterone - constipation/GORD
what are the role of progesterone and oestrogen during pregnancy?
PROGESTERONE - produced by placenta after day 35. Reduces the smooth muscle excitability (uterus/gut/ureters) and increases the body temperature
OESTROGEN - increases breast and nipple growth, water retention
how many days into a pregnancy will the pregnancy test test positive?
9 days post conception
what is the definition of infertility?
inability to conceive pregnancy after 2 years of trying with regular intercourse
cause of infertility?
male causes
unexplained
ovulation failure
tubal damage (chlamydia/PID)
Ix for infertility? what would you be looking at?
semen sample
21 day progesterone (low progesterone –> refer to specialist, if it is high this means that ovulation is occuring.)
how do you score post-natal depression?
Edinburgh post-natal depression scale
Features of a multiple pregnancy?
uterus large for date hyperremesis gravidarum polyhydramnios 2 fetal heart beats multiplicity of fetal parts
what increases the risk of a multiple pregnancy?
family history previous twins IVF increasing maternal age clomifene
name some complications of a twin pregnancy?
polyhydramnios
pre-eclampsia
increased risk of APH
operatie delivery
what is an ectopic pregnancy?
implantation of a fertilised ovum outside of the uterus (commonly within the fallopian tube)
where is the most common site of ectopic pregnancy associated with rupture?
isthmus
what increases the risk of an ectopic pregnancy?
IUCD, PID, endometriosis, previous fallopian tube surgery
what is the presentation of an ectopic pregnancy?
6-8 weeks amenorrhea unilateral pain (radiating to the shoulder) PV bleeding N&V signs of shock
what do you find on examination of a patient having an ectopic pregnancy?
what Ix would you do?
cervical excitation
tender abdomen
adnexal mass
bHCG - >1500
US uterus - empty
How do you manage an ectopic pregnancy?
EXPECTANT - unruptured, no fetal HB, falling hCG - monitor hCG for 48 hours
MEDICAL - methotrexate
SURGICAL - if ruptured, pain, fetal HB, bHCG>1500 - Salpingectomy
what is a miscarriage?
expulsion of conception products <24 weeks
name some causes of recurrent miscarriages?
antiphospholipid syndrome
increasing maternal age
bicornuate uterus
fibroids
what are the features of the 4 types of miscarriage (inevitable, incomplete, missed, threatened)
INEVITABLE - clots, pain, blood, os open
INCOMPLETE - blood, clots, pain, parts of foetus expelled
MISSED - foetus dead, no expulsion yet
THREATENED - painless PV bleed
How can you manage a missed miscarriage?
- Expectant - wait for the foetus to be expelled spontaneously
- MISOPROSTOL (prostaglandin - causes contractions)
- surgical vacuum asipration
how do you manage an abortion?
<9 weeks - Mifepristone (anti-progesterone) + prostaglandins for contractions
>9 weeks - surgical dilation and suction
what is the definition of labour?
regular painful contractions, effacement of cervix, rupture of membranes and release of cervical plug
what do you monitor during labour?
fetal - heart rate (CTG)
contractions
maternal - HR/BP/urine/temp
what problems arise during stage 1 of labour - how do you manage this
inefficient contractions - syntocinin
cephalopelvic disproportion - C section
what are the indications for an operative vaginal delivery?
prolonged 2nd stage of labour maternal exhaustion fetal distress under GP assisted delivery of preterm breech vaginal delivery cord prolapse
what is cord prolapse?
umbilical cord descends below the presenting part of the foetus. Causes cord compression and vasospasm resulting in foetal hypoxia
what are the RF for cord prolapse?
premature, polyhydramnios, multiple pregnancy, long cord
How do you manage a cord prolapse
emergency alarms
try and push the cord as far inwards as [possible
deliver fetus ASAP - C section or instrumental
get the patient on all fours
complications of the PROMS?
maternal - chorioamnionitis, oligohydramnios
fetal - premature, pulm hypoplasia, infection
causes of PROM?
BV, gonorrhea chlamydia
how do you manage PROMs?
monitor temp - ensure no infection
10 days erythromycin
how do you manage pre-term labour?
give corticosteroids - fetal lungs
GBS - give benzylpenicillin
Give an anti-oxytocin - Atosiban
how do you manage breech position?
at 36-37 weeks undergo extracephalic version
C/I to extracephalic version?
twins, placental praevia, uterine scars
how do you manage shoulder dystocia?
- call for help
- episiotomy
- McRoberts manouvre
what is a hydaditiform mole?
proliferating chorionic villi resulting in raised bhCG and increased symptoms of pregnancy
presentation of hydatiform mole?
early miscarriage HG uterus large for gestational age strongly positive pregnancy tests US - snowstorm effect
what is hyperremesis gravidarum?
persistant vomiting, weight loss, ketosis
features of hyperremesis gravidarum?
can’t keep food or drink down, lost weight, dehydration, malloryweiss tear, inability to swallow saliva
Ix for hyperremesis gravidarum?
urine - UTI/ketosis
FBC - raised haematocrit
US - exclude mole
UEs - low K and Na
Mx of hyperremesis gravidarum?
admit - correct UE disturbances and correct hydration status
Daily UEs
anti-emetic - promethazine
RF for uterine rupture
pain during labour
usually occurs on LSCS scars - previous C section
obstructed labour, breech extraction
how to manage a uterine rupture?
category 1 CS
give O2
cross match blood
post op Abx
most common cause of puerperal infection? how do you treat this?
Endometritis
Gentamycin + clindamycin
what is an APH?
genital tract bleeding occuring after 24 weeks
name some causes of APH?
placental abruption, placenta praevia,vasa praevia
how do you manage a APH?
- Admit - US - where is the placenta?
2. IVI - fluids, O2, raise legs
what is abruption? Features of placenta abruption? what is it associated with?
placental detaches from uterus
pain, hard uterus, PV bleed, shock out of keeping with visible losses, fetal HR distressed
ASS: pre-eclampsia, smoking, cocaine, abdo trauma
what is placenta praevia? RF and features?
placenta lying 2.5cm from the internal OS
RF - multiparity, previous C section, uterine surgery
FEATURES - shock proportional to visible losses, no pain, uterus not tender, FHR normal
what is vasa praevia?
fetal placental vessels lie beneath the presenting parth
Rupture - painless PV bleeding, fetal distress, no pain
what does GBS risk to the foetus?
meningitis, pneumonia, septicaemia
when do you give benzylpenicillin in labour? (GBS)
preterm (<37 weeks)
urine sample +ve for GBS
temperature intrapartum
previous child affected by GBS
what is pre-eclampsia?
HTN, proteinuria and oedema - occur after 20 weeks gestation due to failed trophoblastic invasion of the spiral arteries - raised BP
what increased your risk of pre-eclampsia?
previous pre-eclampsia, chronic HTN, SLE, anti-phospholipid, CKD
complications of pre-eclampsia?
HELLP, eclampsia, oedema, ARDS, placental abruption
what are the symptoms of pre-eclampsia/eclampsia?
asymptomatic, headache, RUQ pain, N&V, oedema, flashing lights, hyperreflexia, tonic-clonic seizure
how do you manage pre-eclampsia?
MONITOR: BP, URINE, UE/LFT/FBC, strict fluid balance, steroids for fetal lungs
- Labetalol
- Nifedipine
- Prophylactic MgSO4
how do you manage eclampsia?
MEDICAL EMERGENCY - CALL FOR HELP
- O2/IVI/monitor sats
MgSO4 for seizure (need calcium gluconate to hand)
Monitor FHR
what is HELLP syndrome?
haemolysis, elevated liver enzymes, low platelets
what is the definition of SGA?
birthweight < 2.5kg
1 reading < 10th centile/static growth
how do you manage a foetus which is SGA?
- refer for foetal US -e measure size
2. umbilical artery doppler (26-28 weeks)
what are the RF for SGA?
maternal age > 40 smoking cocaine pre-eclampsia trisomies congenital infections
RF for gestational DM?
BMI>30, previous macrosomic baby, previous gestational DM, 1st degree relative with diabetes
what is the diagnostic criteria for DM?
fasting glucose > 5.6
2hr glucose > 7.8
when do you test for gestational DM?
previous gestational DM - OGTT at booking and at 24& 28 weeks
any RF for gestational DM - OGTT at 24 and 28 weeks
how do you manage gestational diabetes?
- Diet and exercise
- Metformin
- Insulin
what effect does gestational diabetes have on the foetus?
Shoulder dystocia macrosomia polyhydramnios stillborn hypoglycaemia
how do you manage chronic HTN in pregnancy?
switch the medication to labetalol
what is pregnancy induced HTN?
HTN > 20 weeks of pregnancy (no proteinuria or features of pre-eclampsia._)
when do you screen for anaemia during pregnancy?
at booking and 28 weeks
how do you manage a MSU +ve sample (asymptomatic bacteruria) in a pregnant woman?
Cefalexin 500mg TDS
what raises the risk of VTE in pregnancy?
Hx of VTE, family history, thrombophilia, SLE, sickle cell, age >35, obesity, parity >3, varicose veins, pre-eclampsia, immobility, dehydration
how do you manage a VTE in pregnancy?
antenatal LMWH - continue until 6 weeks postpartum
what are primary and secondary PPH?
primary - loss of >500mL blood in first 24hours after delivery of the baby
secondary - loss of >500mL >24hours after delivery
name the causes of a primary PPH?
tone
trauma
thrombin
tissue
name the causes of a secondary PPH?
usually due to retained placental tissue
How do you manage a PPH?
CALL FOR HELP High flow O2, assess airway 2 large bore cannulas cross match blood IV hartmaans
- deliver placenta, empty the uterus of clots
- syntometrine (contracts the uterus)
- repair any vaginal tears
- rusch balloon/compression suture/uterine artery ligation
when do you give anti-D immunoglobunlin?
medical terminations spontaneous miscarriage evacuation of a mole ECV amnioscentesis
what are the contraindications for the COCP?
BMI>30, breast feeding, HTN, VTE history, migraines with aura, breast cancer
how does the COCP work?
inhibits ovulation due to negative feedback, inhibits proliferation of endometrium and thickened cervical mucus
how does the POP work?
thickens mucus in the cervixand to a degree inhibits ovulation, thins the endometrium
how long after unprotected sex can you take levongesterel? how does it work?
use within 72 hours
delays ovulation
how long after unprotected sex can you take ullipristal acetate? how does it work?
120 hours after unprotected sex
progesterone receptor modulator
how long after unprotected sex can you have the IUD fitted?
5 days