Obligate Intercellular bacteria- Chlymidia

Question 1

Chlymidia characteristics (type, how the multiple, target cells)

Answer 1

Gram negative bacteria
multiply thru binary fission
target epithelial cells

Question 2

What are the two states of chylymidia in the life cycle

Answer 2

Elementary body (infectious)
Reticulate body (replicating)

Question 3

steps of the chylmidia life cycle

Answer 3

EB taken into cell
Changes to RB and grows/multiplies
changes back to EB and is extruded of lysed

Question 4

How does chylmidia evade

Answer 4

as an intracellular pathogen it can hide in provilaged intracellular compartments to make themselves immune to mechanisms

Question 5

What are the 2 reportable chlymidia infections

Answer 5

C. Psittaci (causes lung infections)

C. Trachomatis (eye and urogenital infections)

Question 6

C. psittaci- natural host, transmission and s+s

Answer 6

Birds
-transmission via airborne

causes psittacoisis which causes fever, dry cough, and pneumonia

Question 7

C. pneumonia- host, transmission, pathology

Answer 7

Human to human
-thru respiratory droplets

Causes damage to lining of the respiratory tract (cough, horseness, pneumonia)

Question 8

Tx of c. pneumonia

Answer 8

usually self limiting

can be tx w macrolides/tetracyclines

Question 9

c. trachomatis general- hosts, transmisson

Answer 9

Humans only

-finger to eye, sexually, from birth canal

Question 10

trachomatis immunotypes a-c–> transmission, effects, tx

Answer 10

via touch to the eye

starts as conjunctivitis which will then lead to scarring and inward growth of eyelid (can cause blindness)

tx- oral azithromycin and topical tertacycline

Question 11

Trachomatic immunotypes d-k (non gonoccal urethritis)–> clinicl picture in males/females

Answer 11

> 50% cases asymptomatic

m- urethritis and mucoid discharge
f-urethrits, cervitis, discharge

Question 12

Trachomatic immunotypes d-k (non gonoccal urethritis)–> tx + pot. complications (triad)

Answer 12

tx- doxycycline or azithromycin (also tx gonnerhea at same time)

complications- Conjunctivitus, urethritis and arthritis

Question 13

Trachomatic immunotypes d-k (inclusion conjunctivitis) -> causes in kids/adults

Answer 13

neonatal- during childbirth

adult- transmitted sexually or hand to eye contact

tx- oral azithromycin, tetracycline

Question 14

Trachomatic immunotypes L1/2/3 (lymphogranuloma venereum)–> stages , tx

Answer 14

1. Painless papule on ext genitalia
2. Multiplication in regional lymph nodes (fever, headaches, myalgia etc)
3. urethral/rectal strictures, abscesses etc)

tx- Doxycyline for 21 days