*OBJ - Enzymes as Biocatalysts Flashcards
Interpret the energy diagram of an enzyme catalyzed reaction and an uncatalyzed reaction
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Define activation energy and its relationship with the transition state complex formation
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Define binding energy and describe its importance in enzyme catalyzed reactions
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Define transition state, and explain how structural information on the transition state of a reaction can be exploited in drug development
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Distinguish between the lock-and-key model and the induced-fit model for substrate binding
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Describe the active site of chymotrypsin, and explain the major chemical steps leading to peptide bond cleavage
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Identify the specific roles of the active site amino acid residues involved in the peptide bond cleavage
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Distinguish between catalytic transition state and catalytic intermediates and identify their positions in the energy diagram of a given enzyme-catalyzed reaction
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List the functional groups commonly encountered in the active sites of enzymes.
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