Obesity, Metabolism, and Disease Risk Flashcards
Obesity is linked to what diseases?
CVD, Colon cancer, Breast cancer, Joint disorders, Gall Bladder Disease, Sleep apnea, type-2 diabetes
More than ___% of people with __ have are overweight/obese.
More than 85% of people with type-2 diabetes have are overweight/obese.
Insulin resistance causes ?
Insulting resistance causes more FFA and glucose in blood stream
What is insulin resistance?
When tissues that normally respond to insulin don’t
Tissues that are Insulin resistance cause ___ to ___ more ___ causing ____
Tissues that are Insulin resistance cause pancreas to secrete more insulin causing hyperinsulinemia
Beta-cell failure + high glucose =
Beta-cell failure + high glucose = diabetes
With ___ insulin, ____ releases ____ from ____
with ___ insulin, ____ surpressed –> no _____
With ___Insulin, ____ increases uptake of ____ by ___ —> ______
With low insulin, HSL releases FFA’s from adipose tissue
with high insulin, HSL surpressed –> no lipolysis
With high Insulin, LSL increases uptake of lipids by adipose tissue —> lipogenesis
insulin resistance –> ___ does not respond to ____ = ____ levels of ___ and ___ in blood
insulin resistance –> AT does not respond to insulin = higher levels of TG and FFA’s in blood
Obesity alters ___ _____
Obesity alters lipoprotein metabolism
In Obesity and CVD liver takes up more ____ then liver secretes more ___
In Obesity and CVD liver takes up more FFA then liver secretes more VLDL
Atherosclerosis occurs from higher circulating __ and __
Atherosclerosis occurs from higher circulating VLDL and LDL
Obesity promotes cell ____ and suppresses ____
Obesity promotes cell proliferation and suppresses apoptosis
cell/tumor growth can occur from _____
cell/tumor growth can occur from hypertinsuliemia
increase ___ ____ –> increase ___ ___ –> tumor growth (____)
increase adipose tissue –> increase estrogen synthesis –> tumor growth (breast)
