Obesity

Question 1

What are the medications that can CAUSE Obesity???

Answer 1

1. Meds for Diabetes: Insulin, Sulfonylureas, Thiazolidinediones
2. Corticosteroids & Estrogen
3. Antihistamines
4. Anticonvulsants
5. Antipsychotics
6. Antidepressants

Question 2

What are the SECONDARY causes of obesity??

Answer 2

1. Cushing Syndrome
2. Insulinoma
3. Hypothyroidism
4. Polycystic Ovarian Syndrome
5. Hypogonadism
6. PREGNANCY
7. Growth Hormone deficiency

Question 3

What is LEPTIN???? How does it WORK???

Answer 3

*SATIETY hormone that works in the hypothalamus & produced in fat cells.
- Obesity cause decreased Leptin sensitivity bc there’s just so much made, body just becomes resistant to it

Question 4

What are the 4 Classification of body weight??

Answer 4

1. BMI
2. NIH classifications
3. Overall health risk: Presence of obesity related diseases AND Cardiovascular risk
4. Waist circumference:
   - Measure with arms straight down, measure at elbow joint!
   - Men: >40 inches
   - Women: > 35 inches
   BOTH MEANS CENTRAL OBESITY: apple shape!! BAD)

Question 5

how do we measure for WAIST CIRCUMFERENCE?? WHAT DO THE VALUES MEAN????

Answer 5

• Measure with arms straight down, measure at elbow joint!
  
  • Men: >40 inches
  • Women: > 35 inches

BOTH MEANS CENTRAL OBESITY: apple shape!! BAD

Question 6

What are the diagnostic tests for Obesity????

Answer 6

1. SLEEP APNEA testing (overnight sleep study):
   - Obesity cause it
   - Increase risk for HTN and Type II
   - Use CPAP to help w/ sleeping
   ———–
2. DIABETES screen (HgbA1C)
3. DYSLIPIDEMIA testing
4. THYROID evaluation
5. LIVER function test
6. 24hr urine for free CORTISOL (for cushing syndrome)

Question 7

What are the medication that help with weight loss?????**
What classification are they on??
How does it work??
What are the common side effects??
What are the Contraindications and Precautions????

Answer 7

SYMPATHOMIMETIC – mimics the SNS!
1. Phendimetrazine, Dietthylpropion, Benzphetamine, and Phentermine
-Anorexogenic effect, and Increased satiety
A. Common adverse effects:
1. Insomnia
2. Irritability
3. Headache
4. Dry mouth
B. Contraindications: Cardiovascular disease, Hyperthyroidism, Arrhythmias, Agitation, Insomnia, and Glaucoma
C. Caution with HYPERTENSION!!!!!!