Diabetes Flashcards
Insulin are produce where in the body?? How many units does that organ make per day??
Pancreas produces 40-50 units per day!!
What’s the rate of production of insulin when fasting vs when eating???
- Slow & steady when fasting
- Increased rate when eating
What are the 2 functions of Insulin???
- Keeps blood glucose from being too high
- Keeps blood lipids within a normal range
Which cells require insulin for glucose uptake???
- Muscle
- Fat
- Portions of the liver
Which cells don’t require insulin to be able to attach/accept blood sugar??
- Brain
- RBCs
- Cornea
- Intestine
- Kidneys
- Portions of the liver
What are the implications of cells that don’t require insulin?????
It makes these cells vulnerable to the effects of high blood sugar. You wouldn’t need to have enough Insulin around for elevated blood glucose to really work on the brain in a negative way or do something awful to the Red blood cells.
Like Hemoglobin A1C; glucose can readily bind to hemoglobin without the aid of Insulin whatsoever.
Which type of diabetics may be diagnosed several YEARSSS after onset, after complications have already arisen??? and which will show instantly (several days, months)? WHY??
- Type 2 diabetes progression is more gradual!! IT TAKES YEARS FOR TYPE II TO BE DIAGNOSED!!!!!!
- Type I will be diagnosed faster because it’s Autoimmune disorder where ur pancreas is failing! So it’s faster!
Anything in between Normal and Diagnostic for diabetes is known as what??????** What does it mean?
Impaired glucose tolerance!!!!!!!!!!!!!
Means that we’re not diagnosed with diabetes yet, but we’re also not normal!
Who’s going to get away with monitoring their blood glucose less frequently???? WHY?
Type II diabetics may not need to monitor it as closely because a lot of them are not on insulin or drugs that directly influence insulin production!!!
T/F? many diabetics gonna deal with hypertension??
TRUE
Fat is broken down into what when we need energy/glucose?
Ketones!
Whenever u find a diabetic who’s looking down, which is always the safe measurement..? Assuming that they are hypoglycemic or hyperglycemic first??
ALWAYS ASSUME THAT THEY ARE HYPOGLYCEMIC!!!!!!!!
BECAUSE even if they are not, we can deal with High blood sugar WAY more effectively than we can deal with Low blood sugar!
What is the 15-15 rule of hypoglycemia?
For giving glucose orally, give 15 grams of glucose then check the Blood glucose in 15 minutes!! Repeat until their BG is within normal range. THEN FOLLOW UP WITH MEAL/SNACK (Complex Carb!!) to prevent secondary hypoglycemia and help liver store glycogen!!!!
What should you do AFTER giving any treatment for hypoglycemia????
What’s the purpose of that?
FOLLOW UP WITH A MEAL OR SNACK (COMPLEX CARBS!) To:
Prevent Secondary hypoglycemia and restore liver glycogen!!!!!
What are the Examples of 15 grams of carbs to treat hypoglycemia???? Including ATI examples!!!
- 1/2 banana
- 1/2 cup of orange juice
- 1 tablespoon of sugar/honey
- 4-5 Saltine Crackers
- 3-4 Glucose Tablets
- 1/2 cup of oatmeal
- 1 Slice of bread!!
- Small piece of fruits!!!
——-
ATI: - 6 saltines
- 8 oz or 1 cup of MILK
- 6-10 hard candies
- 1/3 cup of yogurt
- 1/2 cup of Ice cream!!!!
What are teachings to give family and friends when giving Glucagon Injection to someone who’s hypoglycemic????
- signs of Hypoglycemia
- Injection sites: IM and SC
- Recovery position (left side!!!)
- TACHYCARDIA POSSIBLE
- IF UNSURE, CALL 911!!!!
The only way to know for sure that BG is low is how??? What should you assume if there’s none of that??
By glucose meter or Blood draw!!! In doubt, ALWAYS ASSUME HYPOGLYCEMIA!!!!!
Hypoglycemia can ultimately cause what???
Coma or Stroke, then death!!!! ☠️
What contribute to the manifestations of hypoglycemia and what are the manifestations of it??
SNS Activation and Low Blood glucose to CNS (brain)!!!!!!!!!
“SSSS, PP, FDD, Wah!”
1. Shaking
2. Swearing
3. Slurred Speech
4. Sleepiness
—-
5. Palpitations
6. Parathesia (numbness n tingling on ur limbs)
——
7. Fatigue
8. Dizziness
9. Difficulty THINKING
——
10. Weakness/ Loss of coordination!!
What patient EDUCATION WOULD YOU GIVE FOR HYPOGLYCEMIA!????
1) How to AVOID hypoglycemia:
1. Exercise carefully
2. Regular meals
3. Monitor BG before Meds!!!
2) Wear Medic Alert BRACELET!!
3) Signs and symptoms of hypoglycemia
4) Watch for signs of hypoglycemia when blood glucose is >65-70 mg/dL (consider their normal values)
5) Hypoglycemic Unawareness:**
1. SNS Impairment!!!! Can be due to BETA BLOCKER!!!
2. May contribute to:
- Frequent episodes of hypoglycemia
- Long term diabetes
- Strict control diabetes
What is the Hypoglycemic Unawareness due to???***
- SNS Impairment!!!! Can be due to BETA BLOCKER!!!
- May contribute to:
- Frequent episodes of hypoglycemia- Long term diabetes
- Strict control diabetes
Which insulin is the cloudy insulin?????**
INTERMEDIATE!!!!!!!
which background insulin can we mix rapid and short acting insulin with?????***
INTERMEDIATE is the ONLY CLOUDY insulin!!! Meaning that we can only mix a rapid or short with an intermediate!!!! (NEVER with long acting)
Which type of insulin can you give in IV form?????***
ONLY REGULAR INSULIN (Short acting insulin)!!!!!!!!!!!!!
NEVER INTERMEDIATE OR LONG!!!!
Why would you ever give IV insulin???
- When pt is in diabetic Ketoacidosis or HHS, to give constant insulin
- When they have BURN all over their body and sticking insulin would be hard
- When they have GENERALIZED EDEMA
What are the examples of Intermediate insulin??
(The ones that end with an ‘N’)
NPH, Humulin N, Novolin N
What are the examples of Long insulin??
Determir (Levemir), Glargine (Lantus)
What are the examples of Rapid insulin??
(“Huma has a Lisp” and Nova is an Ass”)
Lispart (Humalog) and Aspart (Novalog)
What are examples of Short Insulin???
(The Regular’s)
Humulin Regular, Novolin Regular
What are the 2 types of Background Insulin?? What do you need to know about them?
1) Intermediate Insulin:
1. Dose only 2x a day because they only work 1/2 a day
2. THE ONLY CLOUDY INSULIN!!!!!!!! (meaning that you can only mix rapid or short with intermediate!!)
2) Long acting Insulin:
1. NO PEAKS. Gives a 24 hr STEADY coverage!!!
2. DON’T MIX LONG ACTING WITH ANYTHING ELSE IN THE SAME SYRINGE!!!
What are The Mealtime/Breakthrough Insulin?? What do you need to know about them?
- Rapid acting: Work almost immediately (faster than short), DON’T GIVE until FOOD IS READY!
- Short acting: Work immediately, but little later after rapid, DON’T GIVE until FOOD IS READY!
BOTH:
- MONITOR FOR HYPOGLYCEMIA FOR EITHER RAPID OR SHORT IN THE MORNING!!
What do you need a monitor after giving someone a rapid or short insulin?????
MONITOR FOR HYPOGLYCEMIA!!!!!!!!!!!!!
What is the initial non-insulin therapy for Type 2 Diabetes???? How does it work?? What are the 3 side effects?? patient teachings??
Glucophage (Metformin), a biguanide.
1. Decrease liver production of glucose
2. Increase cell sensitivity to insulin
3. Decrease CHOLESTEROL
4. WEIGHT LOSS
—-
Side effects:
1. GI UPSET
2. LACTIC ACIDOSIS
3. NOT FOR PATIENT WITH KIDNEY DISEASE!!!
—
1. Withold 48 hours BEFORE and AFTER surgery for any test where CONTRAST is used!!!!!!!! WHY? Because interaction can lead to increase risk for kidney dysfunction & lactic acidosis
2. SIGNS OF LACTIC ACIDOSIS: “MMARS”
- Malaise
- Muscle pain
- Abdominal distress
- Respiratory distress
- Somnolence
What are examples of Sulfonylureas and Meglitinides???? How do they work and What are major side effects/teaching????
Sulfonylureas: Glipizide (Glucotrol), Glyburide (Diabeta)
Meglitinides: Repaglinide (Prandin), Netaglinide (Starlix)
How they work?
1. Stimulate betta cell production of Insulin
2. **Decrease Liver production of glucose!!
–
Side effects:
1. Weight gain
2. Hypoglycemia
3. Plan to eat! Monitor BG
4. Shouldn’t be used in pt with kidney dysfunction
5. SULFA ALLERGY (Due to Sulfonylureas ONLY): IS OKAY FOR PATIENT WITH SULFA SENSITIVITY TO TAKE!!
What are examples of Thiazolidinediones???? How do they work and What are major side effects/teaching????
Piolitazone (Actos) and Rosiglitazone (Avandia)
How they work?
1. Increase cellular sensitivity to Insulin
–
Side effects/ teaching:
1. Weight gain
2. Edema
3. Heart failure . OTHER cardiovascular risk: Fluid retention, Increase LDL
–
4. liver Enzyme elevate
5. OKAY IN PATIENT WITH RENAL DYSFUNCTION
–
6. Contraceptive needed
7. Anovulatory women may resume ovulation. Birth control
Wherever glucose goes, what follows it??
Water follows!!
Osmotic diuresis (Volume loss and elyte loss) As well as Polyphagia in Hyperglycemia can lead to what????**
WEIGHT LOSS!!!!! Because of water loss (with osmotic diuretic) and breakdown of fat and protein (polyphagia)
Hyperglycemia** can cause what 3 P’s??
Polydipsia (excessive thirst), Polyuria, and Polyphagia!!!!!
What electrolytes do you lose along with osmotic diuresis???
Sodium, potassium, Chloride, and water
Why do patients with hyperglycemic tend to lose weight????
Because they are losing water from osmotic diuresis (dehydrated) and also due to the liver breaking down fat and protein because of polyphagia; cells that aren’t getting the glucose, bc either insulin is not produced or cells not responding to insulin, will send the message to the body saying that they are HUNGRY and so body will tell the liver to start breaking down fat (into ketones) and protein causing WEIGHT LOSS!!!!!!
What are other potential manifestations in the Newly diagnosed TYPE I diabetics??????***
- Bedwetting in Kids
- ## Irritability and mood changes
- Blurred vision
- Fatigue, weakness, sleepiness!!!
What does it mean when Type II diabetes may present with evidence of complications???
- Many of them will present for the FIRST time because of their complications. They may have type 2 diabetes for many years without realising it and often diagnosed when they are presented with other complication such as they aren’t able to see well so they went to see the doctor and turns out they have Type II diabetes!!!
- Since with Type II diabetes they progress more GRADUALLY, by the time TYPE II has been diagnosed, the blood sugar has destructed the body from head to toe
What are the 3 major classifications of POTENTIAL COMPLICATIONS of diabetes mellitus????!!!**
3 major classifications!!!!
- Things that can kill you OVER THE COURSE of their lifetime (long-term): Cardiovascular disease, Renal failure, Neuropathy, wound healing delay, and Eye changes!!!!!!!
- Things that can kill you in SEVERAL WEEKS TO DAYS because of infection, illness, or stress: DKA & HHS
- Things that can kill you RIGHT NOW: HYPOGLYCEMIA!!!!!!!!!!!!!!
What does Hyperglycemia do to blood vessels?? Serum Lipids????***
- Vessel wall thickening
- Tendency toward vasoconstriction
- Serum lipids not stored appropriately
What are the most VULNERABLE PARTS of the body in the diabetics??????**
- Blood vessels
- Nerve roots
- ## WBC
- Eyes
- Cardiovascular issues, including cerebrovascular, so Stroke risk. Remember: THE LEADING KILLER OF DIABETICS IS HEART DISEASE & HEART ATTACK!!!!!
- Atherosclerosis
- Feet
- Kidneys
What does hyperglycemia do to the ability of RBC’s to carry and deliver oxygen???? (talk about Hemoglobin A1C and also Pulse ox!!!!!!)
- RBCs become saturated with glucose (GLYCOSYLATION)!!!!
- ## Glucose binds to Hgb where oxygen should!!!!!!!
- Hemoglobin A1C: glucose is going to bind with RBCs since they don’t need Insulin to attach to glucose! They’ll bind to where oxygen is supposed to bind with RBC. Now, since glucose has occupied that binding site, it’s going to bind for the lifespan of that RBCs!!! Then, OXYGEN WON’T BE ABLE TO BIND W/ RBC, WHICH DECREASES THE ABILITY FOR OXYGEN TO BE CARRIED EFFECTIVELY THROUGHOUT THE BODY!!!!
- Pulse Oximeter does NOT accurately reflect this!! It’s only telling us how saturated our blood cells are, NOT what it’s saturated with!!!!!!!!!!!!!!!!!!!!!
What does GLYCOSYLATION mean????
When RBCs become saturated with glucose!!!!!!!!