Obesity

Question 1

Orlistat

Answer 1

Inhibit fat absorption by inhibit gastric and pancreatic lipase enzyme

Question 2

Lorcaserin

Answer 2

5-HT agonist > satiety by increase POMC production

Question 3

Phentermine

Answer 3

Appetite suppressant by induce NE+SER.+Dopamine release in the brain.
Also in peripheral induce NE+N formation ==> fat breakdown

Question 4

Sibutramine

Answer 4

Monoamine reuptake inhibitor

Decrease appetite

Question 5

Topiramate

Answer 5

It is anti-convulsion drugs. treatment for alcoholic, antipsychotic induced wight gain.
na channel blocker , its mechanism is unknown

Question 6

Metformin

Answer 6

It is an anti-diabetic (Type 2) lead to weight reduction in some individual

Question 7

Note

Answer 7

The obese state is also characterized by a decreased growth hormone

Question 8

Vaccines

Answer 8

Anti-adipose tissue antigen => decrease lipid in circulation and increase HDL

Anti-somatostatin => increase in growth hormone secretion

Anti-GIP => no insulin secretion after ingestion

Anti-ghrelin