Ob: teratogenic agents Flashcards
fetal renal tubular dysplasia and neonatal renal failure
oligohydramnios
IUGR
lack of cranial ossification
ACEIs
growth restriction before and after birth
mental retardation
midfacial hypoplasia
renal and cardiac defects
alcohol
-consumption of > 6 drinks per day is an assoc 40% risk of fetal alcohol syndrome
virilization of females
advanced genital development in males
androgens
neural tube defects fingernail hypoplasia microcephaly developmental delay IUGR
carbamazepine
bowel atresias congenital malformation of the heart, limbs, face and GU tract microcephaly IUGR cerebral infaarctions
cocaine
clear cell adenocarcinoma of the vagina or cervix
vaginal adenosis
abnormalities of the cervix and uterus or testes
possible infertility
diethylstilbestrol (DES)
increase spontaneous abortion rate
stillbirths
lead
congenital heart disease (Ebstein anomaly)
lithium
increase spontaneous abortion rate
methotrexate
cerebral atrophy michrocephaly mental retardation spasticity seizures blindness
organic mercury
IUGR mental retardation microcephaly dysmorphic craniofacial features cardiac defects fingernail hypoplasia
phenytoin
microcephaly
mental retardation
radiation
-medical diagnostic radiation delivering < 0.05 Gy to the fetus has no teratogenic risk
hearing loss
CN VIII damage
streptomycin
kanamycin
permanent yellow-brown discoloration of deciduous teeth
hypoplasia of tooth enamel
tetracycline
bilateral limb deficiencies
anotia and microtia
cardiac and GI anomalies
thalidomide
cleft lip or cleft palate
cardiac defects
microcephaly
mental retardation
trimethadione
paramethadione
neural tube defects (spina bifida)
minor craniofacial defects
valproic acid
increase spontaneous abortion rate microtia thymic agenesis cardiovascular defects craniofacial dysmorphism microphthalmia cleft lip or cleft palate mental retardation
Vit A and derivatives
nasal hypoplasia and stippled bone epiphyses
developmental delay
IUGR
opthalmologic abnormalities
warfarin
