Drug Side Effects

Question 1

ACE-Is

Answer 1

cough

rash

proteinuria

angioedema

taste changes

teratogenic effects

Question 2

amantadine

Answer 2

ataxia

livedo reticularis

Question 3

aminoglycosides

Answer 3

ototoxicity

nephrotoxicity (Acute tubular necrosis)

Question 4

amiodarone

Answer 4

acute: AV block, hypotension, bradycardia
chronic: pulmonary fibrosis, peripheral desposition leading to bluish discoloration, arrhythmias, hypo/hyperthyroidism, corneal deposits

Question 5

amphotericin

Question 6

antipyschotics

Answer 6

sedation

acute dystonic reaction

akathisia

parkinsonism

tardative dyskinesia

NMS

Question 7

-azoles (ex: flucanozole)

Question 8

AZT

Question 9

Beta Blockers

Question 10

benzodiazepines

Answer 10

sedation

dependence

respiratory depression

Question 11

bile acid resins

Question 12

carbamazepine

Answer 12

induction of p-450 enzymes

agranulocytosis

asplastic anemia

liver toxicity

Question 13

CCBs

Answer 13

peripheral edema

constipation

cardiac depression

Question 14

chloramphenicol

Question 15

cisplatin

Answer 15

nephrotoxicity

acoustic nerve damage

Question 16

clonidine

Question 17

clozapine

Question 18

corticosteroids

Answer 18

mania

hyperglycemia (acute)

immunosuppression

bone and mineral loss

thinning of the skin

easy bruising

myopathy

cataracts (chronic)

Question 19

cyclophosphamide

Question 20

digoxin

Answer 20

GI disturbance

yellow visual changes

arrhythmias (junctional tachycardia or SVT)

Question 21

doxorubicin

Question 22

ethyl alcohol

Answer 22

acidosis

renal dysfunction

CNS depression

Question 23

Fluoroquinolones

Answer 23

cartilage damage in children

Achilles tendon rupture in adults

Question 24

furosemide

Question 25

gemfibrozil

Answer 25

myositis reversible elevation in LFTs

Question 26

halothane

Answer 26

hepatotoxicity **malignant hyperthermia**

Question 27

HCTZ

Question 28

HMG-CoA reductase inhibitors

Question 29

hydralazine

Question 30

hydroxychloroquine

Question 31

Isonizid (INH)

Answer 31

peripheral neuropathy (**prevented with pyridoxine/ Vit B6)** hepatotoxicity inhibition of p-450 enzymes seizures with overdose hemolysis in G6PD deficiency

Question 32

MAO-Is

Question 33

methanol

Answer 33

blindness ion-gap metabolic acidosis

Question 34

methotrexate

Answer 34

hepatic fibrosis pneumonitis anemia

Question 35

methyldopa

Question 36

metronidazole

Answer 36

disulfiram reaction vestibular dysfunction **metallic taste**

Question 37

niacin

Answer 37

**cutaneous flushing**

Question 38

nitroglycerin

Answer 38

hypotension tachycardia headache tolerance

Question 39

penicillamine

Question 40

penicillin/ B-lactams

Answer 40

hypersensitivity reaction

Question 41

phenytoin

Question 42

prazosin

Question 43

procainamide

Answer 43

drug-induced SLE

Question 44

propylthiouracil

Answer 44

agranulocytosis aplastic anemia

Question 45

quinidine

Question 46

reserpine

Question 47

rifampin

Question 48

salicylates

Answer 48

fever hyperventilation with **respiratory alkalosis and metabolic acidosis** dehydration diaphoresis hemorrhagic gastritis

Question 49

SSRIs

Answer 49

anxiety **sexual dysfunction** serotonin syndrome if taken with MAO-Is

Question 50

succinylcholine

Answer 50

**Malignant hyperthermia** hyperkalemia

Question 51

TCAs

Answer 51

sedation coma anticholingergic effects seizures **QRS prolongation** arrhythmias

Question 52

tetracyclines

Answer 52

tooth discoloration photosensitivity fanconi's syndrome GI distress

Question 53

trimethoprim

Answer 53

megaloblastic anemia leukopenia granulocytopenia

Question 54

valproic acid

Question 55

vancomycin

Question 56

vinblastine

Answer 56

severe myelosuppression

Question 57

vincristine

Answer 57

peripheral neuropathy paratlytic ileus