Drug Interactions and Reactions Flashcards
1
Q
induction of p-450 enzymes
A
quinidine barbiturates st john's wort phenytoin rifampin grisefulvin carbamazepine
2
Q
inhibition of p-450 enzymes
A
cimetidine ketoconazole INH grapefruit erythromycin sulfonamides
3
Q
metabolism by p-450 enzymes
A
benzodiazepines amide anesthetics metoprolol propranolol nifedipine phenytoin quinidine theophylline warfarin barbituates
4
Q
increased risk of digoxin toxicity
A
quinidine
cimetidine
amiodarone
CCB
5
Q
competition for albumin-binding sites
A
warfarin
ASA
phenytoin
6
Q
blood dyscrasias
A
ibuprofen
quinidine
methyldopa
chemotherapeutic agents
7
Q
hemolysis in G6PD-deficient patients
A
sulfonamides isoniazid ASA ibuprofen nitrofuratoin primaquine pyrimethamine chloramphenicol
8
Q
gynecomastia
A
spironolactone estrogens digitalis cimetidine chronic alcohol use ketoconazole
9
Q
steven-johnson syndrome
A
anticonvulsants
sulfonamides
penicillin
10
Q
photosensitivity
A
tetracycline
amiodarone
sulfonamides
11
Q
drug-induced SLE
A
procainamide hydralazine isoniazid penicillamine chlorpromazine methyldopa quinidine
