OB/GYN Flashcards

1
Q

What is gravidity

A

the number of times a woman has been pregnant

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2
Q

What is parity

A

The number of pregnancies that led to a birth beyond 20 weeks gestational age OR an infant weight > 500g

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3
Q

What is P####

A
(TPAL)
the number of term deliveries,
the number of preterm deliveries
the number of abortuses
the number of living children
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4
Q

What is the developmental age

A

the number of weeks and days since fertilization; usually unknown

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5
Q

What is gestational age

A

the number of weeks and days measured from the first day of the last menstrual period (LMP)

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6
Q

When is CRL considered

A

Crown Rump Length

6-12 weeks

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7
Q

When is BPD considered

A

Biparietal Diameter

After 13 weeks

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8
Q

What trimester is ultrasound measurement considered most accurate

A

1st

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9
Q

What is the standard of diagnosis for pregnancy

A

b-hCG

range of 1000-1500 IU/mL

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10
Q

Discuss b-hCG

A

Produced by the placenta
Peaks at 100,000 mIU/mL by 10 weeks GA
Decreases throughout the 2nd trimester, levels off during the 3rd

hCG levels double every 48 hours during early pregnancy

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11
Q

When is the gestational sac visible by ultrasound?

A

5 weeks GA

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12
Q

What happens to renal flow during the pregnancy

A

Increases 25-50%.

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13
Q

What happens to GFR during pregnancy

A

Increases early, then plateaus

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14
Q

What happens to uterine weight during pregnancy

A

Increases from about 60-70g to about 900-1200g

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15
Q

What is the average amount of weight gain for mothers during pregnancy

A

25 pounds (11-kg)

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16
Q

What happens to HR during pregnancy

A

increases gradually by 20%

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17
Q

What happens to BP during pregnancy

A

gradually decreases by 10% by 34 weeks, then increases to pregnancy values

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18
Q

What happens to stroke volume during pregnancy

A

Increases to a maximum at 19 weeks, then plateaus.

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19
Q

What happens to cardiac output during pregnancy

A

Rises rapidly by 20%, then gradually increases an additional 10% by 28 weeks

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20
Q

What happens with peripheral venous distention during pregnancy

A

Progressive increase to term

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21
Q

What happens to Peripheral vascular resistance during pregnancy

A

progressive decrease to term

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22
Q

What happens to respiratory rate during pregnancy

A

unchanged

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23
Q

What happens to tidal volume during pregnancy

A

increases by 30-40%

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24
Q

What happens to the expiratory reserve during pregnancy

A

gradual decrease

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25
What happens to vital capacity during pregnancy
Unchanged
26
What happens to respiratory minute volume
Increases by 40%
27
What happens to blood during pregnancy
Increases by 50% in second trimester
28
What happens to hematocrit during pregnancy
decreases slightly
29
What happens to fibrinogen during pregnancy
increases
30
What happens to Electrolytes during pregnancy
unchanged
31
What happens to sphincter tone during pregnancy
decreases
32
What happens to gastric emptying time during pregnancy
Increases
33
What does the quad screen consist of
MSAFP (maternal serum a-Fetoprotein) Inhibin A Estriol B-hCG
34
What is the unit MoM stand for
multiple of median
35
What is an elevated MSAFP (>2.5 MoM) associated with
``` Open neural tube defects Abdominal wall defects Multiple gestation Incorrect gestational dating Fetal death Placental abnormalities ```
36
What is reduced MSAFP (
Trisomy 21 and 18 Fetal demise Inaccurate gestational dating
37
What is PAPP-A
Pregnancy associated plasma protein
38
What tests are needed to detect down syndrome
PAPP-A Nuchal transparency Free B-hCG When conducted together can determine 91% of down's and 95% of Trisomy 18
39
Using a quad screen what differentiates trisomy 21 from trisomy 18
Trisomy 18: all are decreased Trisomy 21: MSAFP and Estriol are decreased while Inhibin A and B-hCG are increased
40
When is an amniocentesis indicated
1. women >35 at time of delivery 2. conjunction with abnormal quad screen 3. Rh-sensitized pregnancy to obtain fetal blood type or to detect fetal hemolysis 4. Evaluate fetal lung maturity
41
How do you evaluate fetal lung maturity using amniocentesis
lecithin-to-sphingomyelin ratio >2.5 or to detect the presence of phosphatidylglycerol
42
What is the teratogenic defect associated with ACE I
``` fetal renal tubular dysplasia neonatal renal failure oligohydramnios intrauterine growth restriction (IUGR) Lack of cranial ossification ```
43
What is the teratogenic defect associated with Alcohol
Fetal alcohol syndrome | >6 drinks per day has 40% risk
44
What are the deficits with fetal alcohol syndrome
``` growth restriction before and after birth metal retardation midfacial hypoplasia renal defect cardiac defects ```
45
What is the teratogenic defect associated with androgens
virilization of females | advanced genital development in males
46
What is the teratogenic defect associated with carbamazepine
``` neural tube defects fingernail hypoplasia microcephaly developmental delay IUGR ```
47
What is the teratogenic defect associated with cocaine
``` bowel atresias congentital malformation of the heart limbs, face, and GU Microcephaly IUGR Cerebral infarcts ```
48
What is the teratogenic defect associated with Diethylstilbestrol (DES)
Clear cell adenocarcinoma of the vagina ro cervix, vaginal adenosis, abnormalities of the cervix and uterus or testes, possible infertility
49
What is the teratogenic defect associated with Lead
increased spontaneous abortion (SAB) rate | stillbirths
50
What is the teratogenic defect associated with Lithium
Congenital heart disease (Ebsteins anomaly)
51
What is the teratogenic defect associated with methotrexate
Increased SAB
52
What is the teratogenic defect associated with organic mercury
``` Cerebral atrophy microcephaly mental retardation spasticity seizures blindness ```
53
What is the teratogenic defect associated with phenytoin
``` IUGR Mental retardation microcephaly dysmorphic craniofacial features cardiac defects fingernail hypoplasia ```
54
What is the teratogenic defect associated with radiation
microcephaly mental retardation medical diagnostic radiation delivering
55
What is the teratogenic defect associated with Streptomycin and kanamycin
hearing loss | CN VIII damage
56
What is the teratogenic defect associated with tetracycline
permanent yellow brown discoloration of deciduous teeth | hypoplasia of tooth enamel
57
What is the teratogenic defect associated with Thalidomide
bilateral limb deficiencies anotia and microtia cardiac and GI abnormalities
58
What is the teratogenic defect associated with trimethadione and paramethadione
cleft lip or cleft palate cardiac defects microcephaly mental retardation
59
What is the teratogenic defect associated with Valproic acid
neural tube defects | minor craniofacial defects
60
What is the teratogenic defect associated with vitamin A and derivatives
``` Increased SAB mircotia thymic agenesis cardiovascular defects craniofacial dysmorphism microphthalmia cleft lip or cleft palate mental retardation ```
61
What is the teratogenic defect associated with Warfarin
Nasal hypoplasia and stippled bone epiphyses developmental delay IUGR ophthalmologic abnormalities
62
When does a fetus's endocrine structures begin to function
as early as the 11th week of pregnancy
63
What are the effects of an increased amount of circulating estrogens
1. increase the maternal hepatic procution of binding proteins such as thyroid binding globulin (TBG) and cortisol binding globulin (CBG) 2. Inhibit maternal pituitary gonadotropin synthesis and release 3. Enjance placental production of 11B-hydroxysteroid dehydrogenase
64
What forms hCG
alpha and beta subunits non covalently linked alpha is similar to alpha subunit in the pituitary gonadotropins (FSH, LH, TSH)
65
Where is hCG produced
exclusively the product of the trophoblast, specifically the syncytiotrophoblast
66
When will hCG begin to be produced
as early as 6-8 days post conception
67
what is the significance of abnormally low levels of hCG
miscarriage ectopic pregnancy: (value exceeds 2000 mIU/mL and intrauterine pregnancy not visual on ultrasound.
68
What is the time difference for sensitivity for detecting hCG in the blood versuses serum
blood is 6-8 days of ovulation urine is 14 days of ovulation ONLY after implantation
69
how long after a pregnancy can hCG be detected
4 weeks for normal pregnancy 10 weeks for first trimester abortion or elective early termination
70
What are the biologic functions of hCG
1. maintain the corpus luteum and continue progesterone production 2. regulate fetal testicular testosterone production 3. TSH like properties 4. Clinical uses
71
When is hPL formed
as early as 3 weeks post conception and secreted from the synctiotrophoblast Detectable in maternal serum after 6 weeks
72
What is the biologic function of hPL
1. induces lipolysis and increases maternal free fatty acids, ketones, and glycerol, which provide energy for the mother 2. increased insulin levels
73
What are the 3 potential sources of prolactin
1. anterior lobe of the maternal pituitary gland 2. anterior lobe of the fetal pituitary gland 3. decidual tissue of the uterous
74
What is the biologic function of prolactin
1. preparing the mammary glands for lactation a. stimulates growth of mammilary tissue b. lactation does not occur during pregnancy because estrogen inhibits the action of prolactin on the breast 2. Decidual prolactin regulates fluid and electrolytes of the amniotic fluid
75
Where is progesterone produced in the pregnant state
1. corpus luteum until the 7th week | 2. Placenta after the 8th week
76
What is the biologic function of progesterone
1. prepares the endometrium for implantation of the embryo 2. relaxes the myometrium 3. prevents rejection of the fetus by the maternal immune system
77
What is a progesterone receptor antagonist
mifepristone used as as an abortifacient in the first trimester
78
What are the 3 estrogens and what is the production ratio
1. estrone (14%) - 1 OH 2. estradiol (5%) - 2 OH 3. Estriol (81%) - 3 OH later in the pregnancy estriol is produced almost exclusively by the placenta
79
Can estrogens be produced in the placenta
NO due to a lack of the enzyme necessary to confer pregnenolone to androgen precursors
80
What is do low levels of estrogen signify
1. fetal demise 2. anencephaly 3. Maternal ingestion of corticosteroids 4. placental sulfatase deficiency
81
What are the biologic activities of estrogen
1. stimulate receptor mediated LDL uptake by the placenta 2. Increases blood flow to the uterous 3. Regulates end-of-gestation events Estrogen stimulates epithelial cell proliferation in human breast tissue. However, milk release is delayed until estrogen levels decrease after delivery
82
What increases myometrial gap formation
Estriol
83
What suppresses maternal lympohocyte activity
Progesterone
84
What is necessary fro development of male external genitalia
hCG
85
What is the most sensitive marker for abnormal karyotype
hCG
86
What elevates ketone levels
hPL
87
What hormone is produced by the uterus
prolactin
88
What inhibits lactation during pregnancy
Estriol
89
Lack of this hormone can cause spontaneous abortion in the first trimester
Progesterone
90
Lack of this hormone is associated with an enzyme deficiency in the placenta
Estriol
91
Elevated levels of this hormone are associated with twin pregnancy
hCG
92
Anencephaly causes ack of production of this hormone
Estriol
93
Where are gases and nutrients exchanged between mother and fetus
The villi of the placenta
94
What is the function of the placenta
1. Mother to fetus transfer of nutrients 2. Gas exchange 3. Secretion of proteins and steroids a. Progesterone is produced by the placenta from maternal cholesterol b. Estrogen is converted from circulating fetal androgens produced in the fetal adrenal glands
95
How does the placenta immunologically protect itself from the mother
Invadinging placental cells express a unique antigen, HLA-G which is not recognized as a "foreign" antigen by the mother
96
What forms the umbilical cord
Two umbilical arteries originate from the fetal aorta one umbilical vein returns nutrient rich, oxygen rich blood to the fetus
97
What are the amniotic membranes
Amnion: a single layer of epithelial cells surrounding the fetus and containing the amniotic fluids Chorion: lies adjacent to the uterine endometrium, is exterior and fused to the amnion
98
Where is amniotic fluid derived
primarily from the fetal urine. It is important for the successful development of the bronchial tree
99
What are the requirements for fetal metabolism
1. oxygen 2. glucose 3. amino acids
100
What is the rate of fetal oxygen metabolism
8 ml/kg/min normal adult is 3 ml/kg/min
101
Where does the umbilical vein give branches
to the liver and becomes the ductus venosus
102
What is the function of the ductus venosus
mixes maternal oxygenated blood with fetal deoxygenated blood and flows into the IVC
103
What is the foramen ovale
a right to left intracardiac (atrial) shunt
104
What promotes closure of a PDA
prostaglandin inhibitors
105
What is the function of the ductus arteriosus
connects the left pulmonary artery to the arch of the aorta
106
What maintains the patency of the ductus arteriosus
Prostaglandin E
107
What does the fetal umbilical vein become in the neonate
ligamentum teres
108
The intra abdominal portion of the umbilical arteries of the fetus become what in a neonate
lateral umbilical ligaments
109
What is the normal fetal HR
120-160
110
What is the cardiac output of a normal fetal heart
200 mL/kg/min normal adult is 70 mL/kg/min
111
when do fetal lungs begin to produce surfactant
34 weeks from type II pneumocytes
112
What is the function of surfactant
lowers the surface tension in the alveoli and prevents collapse
113
How is fetal hepatic conjugation of bilirubin
deficient, and a mild hyperbilirubinemia may be seen for the first few days of life
114
Where does hematopoiesis occur
2 weeks: yolk sac 5 weeks: spleen and liver 11 weeks: bone marrow
115
What composes fetal hemoglobin
Fetus: 2 alpha and 2 gamma Adult: 2 alpha and 2 beta At term about 70% hemoglobin is fetal
116
What is the function of the thyroid in fetal development
important for normal neurological development
117
What is the most common immunoglobulin found in the fetus
IgG Only IgG can cross the placenta
118
What are some presumptive symptoms of pregnancy
1. amenorrhea 2. breast changes 3. Nausea (morning sickness) 4. Disturbances in urination 5. Fatigue 6. Sensation of fetal movement
119
What is quickening
the sensation of fetal movement. Usually between the 16th and 20th week
120
What is hegar's sign
Softening between the cervix and the uterine fundus causes a sensation of separateness between these two structures
121
what is chadwicks sign
the vaginal mucosa has a bluish color within the first 6-8 weeks of pregnancy
122
How is pregnancy confirmed
Only two ways 1. Identification of fetal heart beat (120-160) 2. Ultrasonographic representation of a fetus
123
How is EDC (estimated date of confinement) determined
9 calendar months plus 7 days from FDLMP or counting back 3 calendar months and adding 7 days to the FDLMP
124
What is the viability of life if birth occurs in the end of the second trimester
80-90%
125
What is lightening regarding pregnancy
the descent of the fetal head to or even through the pelvic inlet due to the development of a well formed lower uterine segment and a reduction in the volume of amniotic fluid
126
Regarding pregnancy what is a bloody show
a discharge of a combination of blood and mucus caused by thinning and stretching of the cervix, is a sure sign of the approach of labor
127
What is placenta previa
The placenta developing in the lower uterine segment an completely or partially covering the internal os. Usually painLESS heavy bleeding
128
What is abruptio placenta
premature separation of the normal implanted placenta. usually painful bleeding
129
What is normal fetus weight at 26, 36, and 40 weeks respectively
1000g (more than lbs) 2500g (5.5 lbs) 3300g (7-7.5 lbs)
130
What are good indications of fetal lung maturation with reduced risk of RDS
Leithin-to-sphingomyelin (L/S) Ratio of or greater than 2:1 A greater indicator is presence of phosphatidylglycerol
131
What accelerates fetal lung maturation
Glucocorticoids. Stress will increase fetal cortisol production. Administration of maternal glucocorticoids
132
What are the types of fetal presentation
1. Cephalic a. Vertex (chin in) (95%) b. Face (Neck extended) c. Brow (slightly extended but will convert to a vertex or a face during labor) 2. Breech presentation a. Complete b. Incomplete c. Frank
133
What is a complete breech presentation
both the legs and the hips are flexed
134
What is an incomplete breech presentation
one hip is not flexed, and on foot or knee lies below the breech
135
What is a frank breech
the hips are flexed and the legs are extended
136
What is puerperium
period of 4-6 weeks and starts immediately after delivery and ends when the reproductive tract has returned to its nonpregnant condition
137
How does breast feeding accelerate involution of the uterus
stimulation of the nipples releases oxytocin from the neurohypophysis; the resulting contractions of the myometrium facilitate the involution of the uterus
138
What is lochia
uterine discharge that follows delivery and last for 3-4 weeks. Foul smelling lochia suggests: 1. lochia rubra: blood stained fluid last for the first 3-4 days 2. lochia serosa: discharge appears 3-4 days after delivery. It is paler than lochia rubra because it is admixed with serum 3. Lochia alba: after the 10 day, because of admixture with leukocytes, the lochia assumes a white or yellow-white color
139
What kind of contraception can lactating mothers use
Progesterone only oral contraceptions as soon as their milk supply is established. Progesterone only contraceptives do not appear to have adverse effects on lactation.
140
What is the most common cause of postpartum hemorrhage
1. Uterine atony (most common) a. general anesthesia b. multiple fetuses c. prolonged labor d. rapid labor e. high parity f. vigorously stimulated with oxytocin 2. Retention of of placental tissue
141
What are some uterine contracting agents
Oxytocin methylergonovine Prostaglandin F(2a)
142
What is a puerperal infection
infection of the GU tract during the puerperium accompanied by a temperature of 100.4 or higher that occurs for at least of the first 10 days after postpartum EXCLUSIVE of the first 24 hours
143
How is milk production stimulated
Prolactin which is released from the anterior pituitary gland Continuous production is controlled by a stimulus of the breast that curtails the release of prolactin-inhibiting factor from the hypothalamus
144
What is responsible for milk let down
Oxytocin released from the posterior pituitary
145
What kind of drugs or excreted in high concentrations in breast milk
lipid soluble drugs
146
What are the two phases of the menstrual cycle and how do they differ in duration
Follicular is the 1st half and is variable in length. Secretory phase is the second half and is fixed at 12-16 days
147
How is EDC determined
EDC is determined by using naegele's rule. When FDLMP is uncertain, ultrasound can be used. Use LMP unless 1. Ultrasound dating in 1st trimester differs by more than 7-10 days 2. Ultrasound dating in 2nd trimester differs by more than 14 days 3. Ultrasound dating in 3rd trimester differs by more than 21 days.
148
Foamy white vaginal liquid with a strawberry discoloration of the cervix is suggestive of what
Trichomonas
149
White curdy vaginal discharge is suggestive of what
candida
150
Foul-smelling, gray discharge may indicate what
bacterial vaginosis
151
What is the diagonal conjugate
measured from the sacral promontory to the anterior inferior pubic symphysis. can be measured on on pelvic examination
152
what is the obstetric conjugate
the length from the sacral promontory to the posterior pubic symphysis. Measurement is determined by subtracting 1.5 to 2 cm from the diagonal conjugate. The obstetric conjugate is the shortest anterior posterior diameter through which the fetal head must pass.
153
What are the for pelvic types
Android gynecoid platypelloid anthropoid
154
Describe the gynecoid pelvis
``` Most common type (50%) Overall shape is round posterior sagittal diameter of the inlet is only slightly shorter than the anterior sagittal diameter. Ishial spines are not prominent Wide pubic arch ```
155
Describe the android pelvis
overall shape is heart like posterior sagittal diameter of the inlet is much shorter than anterior sagittal, limiting the space for the fetal head ischial spines are prominent Narrow pubic arch
156
Describe the anthropoid pelvis
Overall shape is long and oval Anteriorposterior diameter is greater than the transverse prominent ischial spines narrow pubic arch
157
Describe the platypelloid pelvis
Least frequent | flattened shaped with short anterioposterior diameter and wide transverse diameter
158
What women should be offered genetic testing
All women. Women over the age of 35 should be offered genetic testing through chorionic villous sampling or amniocentesis
159
When is the quad screening performed
15-21 weeks
160
What is the difference between integrated and sequential screening
sequential screening: the results of the first trimester screenings are released to the patient and the provider Integrated screening: the result of the first trimester test is withheld and incorporated into a final overall risk assessment
161
What is the frequent of prenatal visits
every 4 weeks until 24-28 weeks every 2 weeks until 36 weeks weekly until delivery
162
What amount of weight should be gained during pregnancy
Normal BMI: 25-35 lbs less than 19 BMI: 28-40 lbs more than 29 BMI: 15 lbs
163
How many calories should be taken in during pregnancy
2500
164
What food items should be avoided during pregnancy
unpasteurized cheeses raw shellfish fish that have high mercury levels
165
What is the effects of caffeine during pregnancy
greater than 5 cups per day has been associated with an increased risk of spontaneous abortion
166
Are whites or black mothers a greater risk during pregnancy
Blacks: 4X higher maternal mortality 2X perinatal mortality
167
What is the perinatal period
20 weeks gestation - 28 days after birth
168
What are some items that increase risk in pregnant patients
``` Low socioeconomic status Maternal age Less than 20 Maternal age greater than 35 Substance abuse Domestic Violence ```
169
How is a short cervical discovered and what are the associated complications
Cervical length less than 2.5 cm Determined by ultrasound at 20-24 weeks. associated with risk of preterm birth
170
What are the contraindications for a vaginal birth after cesarean
Classical uterine incision Active herpes infection Myomectomy Placenta previa
171
What is eisenmengers syndrome
he process in which a left-to-right shunt caused by a congenital heart defect causes increased flow through the pulmonary vasculature, causing pulmonary hypertension,[1][2] which in turn causes increased pressures in the right side of the heart and reversal of the shunt into a right-to-left shunt. In adults, the most common causes of cyanotic congenital heart disease are Eisenmenger syndrome and tetralogy of Fallot. Eisenmenger's syndrome specifically refers to the combination of systemic-to-pulmonary communication, pulmonary vascular disease, and cyanosis.
172
What happens to clotting factors during pregnancy
Increased production of clotting factors by the liver. Increases the risk of thromboembolic events
173
What congenital abnormality in the fetus is associated with maternal Rho and La antibodies
associated with greater risk of congenital hear blocks
174
What is consanguinity
marriage between close relatives
175
What effect may the use of Paxil (paroxetine) have on fetal development
greater risk for fetal cardiac malformations
176
When is a gestational diabetes screen completed
24-28 weeks with a 1 hour 50g glucose test
177
What can be used to reduce incidence of neural tube defects
0.4 mg folic acid daily reduces incidence in the general population by 50% 4 mg daily in patients with previous NTD pregnancies will reduce risk by 70%
178
What is the most common cause of inherited mental retardation
Fragile X
179
What is the inherritance pattern of fragile x
X linked recessive
180
When are serum markers drawn during pregnancy
``` First trimester ( 10weeks 4 days - 13 weeks 6 days) Included are: MSAFP B-hCG PAPP-A ``` ``` Second trimester (15-22 weeks) Included are: MSAFP B-hCG Estriol Inhibin A ```
181
What invasive testing is done in the first trimester
CVS (Chorionic Villus Sampling) done in weeks 10-12 Risk of fetal loss is 1% Rh negative women who are not sensitized receive Rho(D) immune globulin after the procedure
182
What invasive testing is done in the second trimester
Amniocentesis Risk of loss is 0.25 - 0.5% If conducted in the 3rd trimester, the risk of preterm delivery is 1-2% Rh negative women who are not sensitized receive Rho(D) immune globulin after the procedure
183
An increase in NT (nuchal translucency) is suggest what
Trisomy 18 or Trisomy 21 Estriol is increased with 18 Estriol is decreased with 21
184
What is the most common inherited disorder in caucasions
Cystic fibrosis | Carrier rate is 1 in 25
185
What is the most common mutation associated with CF
Delta F508 There are 23 mutations that are tested in genetic screens which accounts for 80% of cases It is an autosomal recessive trait
186
What are the 3 types of normal hemoglobin
Hemoglobin A: 2 alpha and 2 Beta chains (95%) Hemoglobin A2: 2 Alpha and 2 delta Hemoglobin F: 2 alpha and 2 Gama
187
What is the most common inherited trait in african americans
Sickle Cell Frequency of trait is 1 in 12 Autosomal recessive inheritance
188
What is Tay Sachs disease
the congenital absence of the enzyme hexosaminidase A, which results in an over accumulation of GM2 gangliosides, leading to severe progressive neurologic disease causing death in early childhood Carrier rate in Ashkenazi Jews is 1 in 30 Autosomal recessive inheritance
189
What is an ultrasound
low energy high frequency sound wave | Frequencies between 3.5 and 5 MHz
190
What are the determining factors for amniotic fluid on ultrasound
Measurement of the deepest single pocket of amniotic fluid | 8cm polyhydramnios
191
How is fetal well being measured during a 3rd trimester ultrasound
Biophysical profile 1. Amniotic Fluid 2. Fetal Tone 3. Fetal Movements 4. Fetal breathing 5. Nonstress test score of 2 is normal 0 is abnormal for each section. Total score of 8-10 is normal
192
When is fetal echocardiography indicated
``` Risk factors for CHD (congenital heart disease) suspected CHD's on ultrasound suspected fetal arrhythmia other congenital abnormality nonimmune hydrops fetalis ```