OB Flashcards
What is the reason for increased CO and RBF in pregnancy?
Progesterone
Acid base status in pregnancy and reason?
Chronic rep alkalosis with metabolic compensation, increase PaO2 and decrease PaCO2. Progesterone stimulates resp center to increase TV and Minute ventilation
Highest accuracy for detecting gestational age is when and how?
7-10 weeks measuring crown rump length with accuracy +/- 3 days
Diagnosis and tx of PMS?
Menstrual diary. SSRI
In immature early HPG, what is cause of irregular menstrual cycles with lack of periodicity?
Not enough hormone generated such as LH/FSH to INDUCE OVULATION
Trisomy 18 vs Trisomy 21 MSAFP, B-hCG, Estriol, Inhibin A?
Trisomy 18-AFP (decrease), hCG (decrease), Estriol (decrease), Inhibin A (normal)
Trisomy 21-AFP (decrease), hCG (increase), estriol (decrease), inhibin A (increase)
Nonpathologic cause of increased MSAFP?
multiple gestation
1st trimester combined test timing?
9-13 wks
Quad screen timing?
second trimester. 15-20 wks.
Chorionic villous sampling timing, advantages and disadvantages?
10-13 weeks. definitive karyotypic analysis, pain, vaginal spotting, risk of pregnancy loss
Amniocentesis timing, advantages, and disadvantages?
15-20 weeks, definitive karyotypic analysis, pain with risk of bleeding and amniotic fluid leak, risk of injury to fetus, placenta and maternal bowel or bladder
Second trimester U/S timing, advantages and disadvantages?
18-20 weeks, noninvasive and measures growth, anatomy, and position, disadvantage includes not identifying all abnormalities, soft markers are U/S finding of uncertain significance
Cell-free fetal dna timing, advantages and disadvanges?
greater than 10 weeks; can be confirmed via chorionic villi. Noninvase and highly sensitive and specific for aneuploidy but not diagnostic is a disadvangage.
Criteria for chronic HTN with superimposed preeclampsia?
Chronic HTN (less than 20 weeks) and 1 of following: new onset proteinuria or worsening of current proteinuria, worsening of current HTN, or signs of end organ damage
Tx of hyperemesis gravidarum?
Ginger, fluid replacement, dietary modification, pyridoxine +/- doxylamine
Greatest risk factor for uterine rupture?
PRevious uterine surgery
cessation of uterine contraction and sudden onset vaginal bleeding?
uterine rupture
painless vaginal bleeding with ROM?
vasa previa
diagnosis and management of placenta previa?
diagnosis: first transabdominal NO TRANSVAGINAL. C-section at 36-37 weeks and pelvic rest (no digital vaginal exam and no intercourse)
top cause of placental abruption?
maternal HTN
diagnosis and management of placenta abrupto?
diagnosis: transabdominal U/S. management-IV crystalloid and left lateral decubitus to maximize CO and displace uterus off aortocaval vessels
Placental adherence and hemorrhage at time of attempted placental delivery?
Placenta accreta
Fetal effects of eclampsia?
3-5 minutes of fetal bradycardia during seizure followed by compensatory tachycardia and loss of variability
What is intrauterine fetal demise?
Death after 20 weeks and before onset of labor
Management and complications of intrauterine fetal demise and confirmation?
Management-Coagulation studies normal (watchful waiting), coagulation abnormal (induction of labor). Perform autopsy if possible to prevent in future
Complications-DIC from TF release from bleeding decidua into maternal circulation (same complication in placenta abruption)
Confirmation-real time ultrasonography
Unique to each 2nd and 3rd trimester delivery options for fetal death>20 wks?
D+C up till 24 weeks and repeat C-section in 3rd trimester. otherwise introduction of labor or spontaneous labor same for both.
Test to evaluate cervical insufficiency and finding?
Transvaginal U/S (gold standard) w cervix length should be >25 mm at 24 weeks. if
Management of preterm labor
tocolytic (ca2+ channel blocker), mag sul for neuroprotection, and corticosteroids for fetal lung maturity (antenatal corticosteroids)
Indications for post-term pregnancy C-section?
Fetal distress, oligohydramnios
Diagnosis of acute appendicitis in pregnant patientS?
U/S with graded compression technique. Presence of non-compression and dilation of appendix are diagnositic
15 hours after delivery, woman has fever, leukocytosis and bloody vaginal discharge that is non purulent?
Normal postpartum complication with lochia. If foul smelling, consider endometritis
Heroin vs methadone NAS child presentation?
Heroin-within 48 hours. Methadone-48-72 hours
What reflex is lost on affected side of infants with clavicular or humeral fracture during delivery? What is preserved?
Moro. Biceps and grasp
Lost reflex and preserved in erb duchenne?
decrease of biceps and moro. Preserved is grasp
Lost of reflex and preserved in klumpke?
intact moro and biceps. absent grasp
Tx of endometritis?
broad spectrum (clindamycin and gentamicin)
Primary amenorrhea work up?
1) Uterus present or absent (ultrasound or pelvic exam)
2) Uterus present do FSH (low FSH do cranial MRI, high FSH do karyotype (turner)
3) Uterus asent do karyotype and serum testosterone (karyotype XX and normal female testosterone levels means mullerian agenesis, Karyotype XY and normal male levels means AIS)
Age you have to have workup for primary amenorrhea with and without secondary sex characteristics?
With-age 16, without-age 14
1st test for secondary amenorrhea?
b-HCG
1 consequence of secondary hypogonadotropic hypogonadism?
Low bone density and osteoporosis secondary to decreased estrogen
Tx infertility in premature ovarian failure?
in vitro fertilization and donor oocytes
Amenorrhea needs to only be how long to diagnose premature ovarian failure?
3 months. DONT WAIT TILL 1 year to avoid osteoporosis at young age.
Gonad management timeline for cryptorchid gonads?
Unilateral cryptorchid testes in XY male, AIS gonads, turner syndrome?
Unilateral cryptorchid testes-orchipexy AIS gonads (testes in phenotypic females)-after puberty to allow for growth have gonadectomy Turner syndrome-earlier gonadectomy because higher risk of malignancy from streak ovaries
Cause of transverse vaginal septum?
Malformation of urogenital sinus and mullerian ducts
Congenital aromatase deficiency presentation and problems with puberty?
Ambiguous genitalia. Decrease estrogen causes primary amenorrhea, osteoprosis, and tall stature because low estrogen delays growth plate closure
management of hemorrhage at 18th week from vagina with US showing active FHR?
Ressurance and ultrasonogram 1 wk later
Finding on U/S of septic abortion?
Thick endometrial stripe
Incomplete, inevitable or missed abortion management for hemodynamically unstable (heavy bleeding) and hemodynamically stable (mild bleeding)?
Unstable-D+C
Stable-expectant management, prostaglandins e1 (misoprostol), or surgical evacuation
Septicabortion managmenet?
broad spectrum abx, urgent suction curretage for hemodynamically unstable, and hysterectomy if no response to abx, develoment of abscess, or signs of clostridial infection
Ovarian torsion vs ruptured ovarian cyst presentation
Ovarian torsion acute onset with nausea and vomiting, tender adnexa on bimanual and decreased blood flow with doppler US. Ovarian cyst acute onset after strenous activity or sex with fluid around ovary.
What must be done before someone can be worked up for PID if present with fever, chills, new vaginal dischare, lower abdominal pain, dysuria?
Transvaginal U/S to look for tuboovarian abscess
Tx of ovarian/adnexal torsion?
laparoscopy for urgent detorsion. if necrotic or malignant mass, salpingooophorectomy
Palpable breast mass workup
Less than 30 and greater than 30
Less than 30: Ultrasonography; if simple cyst can do needle aspiration (but can reaccumulate so should return in 2-4 months for follow-up). if complex cyst/mss (image guided core biopsy)
Greater than 30: Ultrasonography and mammogram; if suspicious for malignancy, core biopsy
How does fat necrosis present and tx?
Post trauma/surgery with a firm, irregular mass that has ecchymosis and skin/mipple retraction that can look radiographically similar to breast cancer. Biopsy showing fat globules and foamy histocytes in fat necrosis. NO TREATMENT
Most common underlying breast cancer found in paget disease?
Adenocarcinoma
Pain, itching and burning of the nipple that has no resolution with steroids?
Mammary paget disease
Premenopausal woman with bloody discharge from one breast without any palpable mass?
Intraductal papilloma
HER2 positivity for breast cancer predicts reponse to what drugs?
Trastuzumab and anthracycline
Nipple discharge evaluation?
Unilateral, bloody serous, or milky with palpable lump or skin changes-ultrasound and/or mamography (>30)
Milk without palpable lump or skin changes-likely physiologic (check tsh, pregnancy, prolactin, guiac, and maybe mri pituitary)
Most common location of metastases of choriocarcinoma and tx?
Lungs. Presenting with hemoptysis and multiple nodules on CXR. Can also go to brain. This is the metastatic form of Gestational trophoblastic dz. methotrexate or daptinomycin
Pelvic pain, enlarged uterus, and irregular vaginal bleeding?
GTD
Triad of ectopic pregnancy and diagnosis and tx?
Abdominal pain, amenorrhea, vaginal bleeding. Transvaginal U/S showing adnexal mass, empty uterus. Tx. methotrexate or surgical
Define infertility
conceive for greater than 1 year with age less than 35 or greater than 6 months with age greater than 35
Imaging workup for infertility
hyesterosalpinogram (used to diagnose anatomic cause such as tubal obstruction from prior pelvic obstruction)
Pelvic mass evaluation imaging and follow up from studies
Transvaginal u/s and CA-125.
- greater than 10 cm and elevated CA-125, nodular or fixed mass, ascites or evidence of metastasis needs gyn onc evaluation
- non elevated ca-125 or simple cyst less than 10 cm is followed conservatively
Tx of vaginal foreign body
removal with calcium alginate swab or warm water irrigation AFTER local anesthetic is applied
Lichen sclerosus presentation, management, and tx?
- Pruritic vulva with dysuria, dyspareunia, and painful defecation
- Exam: procelein white atrophy with premalignant lesion that must be biopsied to rule out SCC
- Tx topical corticosteroids