Neuro Flashcards
MCA Stroke symptoms
Contralateral paralysis and sensory loss in face and upper limb. Aphasia if stroke is dominant lobe (left) or hemineglect if nondominant (right side). Homonymous hemianopsia (loss of visual field on opposite side of stroke in each eye so left side has right field loss in both eyes so eyes deviate to left)
How do you know what side of the brain speech is controlled by?
Determined by handedness where right handed ppl have left brain dominant
ACA stroke symptoms
motor/sensory loss of contralateral lower limb. can have urinary incontinence
PCA stroke symptoms
Ipsilateral sensory loss of face 9th and 10th CN, contralateral sensory loss of limbs, limb ataxia. Contralateral sensory loss of limbs. Limb ataxia
Best initial/most accurate test for stroke?
Initial: CT scan, Accurate: MRI
Tx for stroke
3-4.5 for ischemic/TIA-aspirin; if on aspirin, add dipyramidole or switch to clopidogrel
Hemorrhage: nothing, but control BP and reverse anticoag
What drug is essential for all stroke patients?
Statin regardless of LDL level
Appearance of hemorrhage vs ischemic on CT scan
Hemorrhage-white, Ischemic-black
Follow up tests for stroke to find cause
1) ECHO
2) EKG and Holter if EKG normal
3) Carotid duplex
Strongest risk factor with strokes
HTN
Major causes of intracerebral vs subarachnoid hemorrhage
Intracerebral-uncontrolled HTN, Subarachonid-Sacular/ berry aneurysm or AV malformation rupture
Tx for stroke with evidence of AFIB
Long term anticoagulation (eg warfarin, dabigatran, rivaroxaban)
Strict contraindication tPA
Hemorrhagic stroke, stroke/head trauma 185/110, Platelet1.7 INR, PT>15, Increase PTT
Basal ganglia hemorrhage neurologic findings?
Contralateral hemiparesis and hemisensory loss, homonymous hemianopsia, gaze palsy
Cerebellum hemorrhage neurologic findings?
Medial vermis-vertigo and nystagmus
Later vermis-dizziness, ataxia, and weakness
-Ataxia, nystagmus, facial weakness, occipital headache and neck stiffness
Thalamus hemorrhage neurologic findings?
Contralateral hemiparesis and hemisensory loss, nonreactive miotic pupils, upgaze palsy, eyes deviate Towards hemiparesis
Cerebral lobe hemorrhage neurologic findings?
Contralateral hemiparesis (frontal lobe), contralateral hemisensory (parietal lobe), homonymous hemianopsia (occipital lobe), eyes deviate away from hemiparesis, high incidence of seizures
Pons hemorrhage neurologic findings?
Deep coma and total paralysis within minute with pinpoint reactive pupils.
SAH complications?
Rebleeding in 1st 24 hours and cerebral vasospasm after 3 days (prevent with nimodipine)
Cushing reflux to increased ICP?
Hypertension, bradycardia, decreased resp rate
When is imaging done for tension, migraine, cluster?
Unsure of diagnosis or recent started syndrome indicates head CT or MRI
Test pseudotumor cerebri and tx.?
CT or MRI to exclude mass and opening pressure >250 on LP. Tx. acetazolamide to decrease CSF and stop offending medication if applicable
Test giant cell?
Best initial: ESR. Most accurate: Biopsy
Tx/prophylaxis tension headache?
NSAIDs/acetaminophen as tx and no prophylaxis
Tx./ prophylaxis migraine headache?
tx. Triptans, IV antiemetics (chlorpromazine). Prophylaxis >3 attacks/month: propranolol
Tx./prophylaxis cluster headache?
tx.100%o2 as abortive, subcutaneous sumitriptan, octreotide. prophylaxis: verapamil, phenytoin, ergot prednisone
Tx. protocol 1,2,3 for trigeminal neuralgia?
1) Carbamazepine/oxcarbamazepine
2) Baclofen/Lamotrigine
3) Gamma knife surgery
When is shingles vaccine indicated?
> 60
What electrolyte does not cause seizures?
Potassium disorder
Tests before EEG with 1st unprovoked seizure
CMP (electrolyte, glucose, kidney func, renal function), CT/MRI, Urine drug screen
Tx. of status epilepticus?
1) Benzos
2) Phenytoin or fosphenytoin
3) Phenobarbitol
4) NM Blockade (succinylcholine, vecuronium) followed by intubation and general anesthesia after (propofol or midazolam)
Pheyntoin side effects?
- AV block
- Hypotension
Consequence of prolonged seizure >5 minutes seen in status epilepticus?
Excitatory cytotoxicity (cortical laminar necrosis) especially common in those noncompliant to therapy
Complication of tonic clonic seizure?
Shoulder dislocation
Exception to rule where you should not start epileptic drug after single seizure?
Family hx, status epilepticus, abnormal EEG or CT lesion
Best test to tell if possibility of seizure recurrence?
Sleep deprivation EEG
What differentiates SAH from meningitis?
Loss of consciousness in 50% and very sudden onset
Best initial/most accurate SAH?
Noncontrast CT, LP showing blood w/ 1:500-1000 WBC to RBC ratio
Head CT w or w/o contrast indications?
CT w/o-suspecting blood. CT w/ cancer or infection
Tx. SAH?
1) Nimodipine, 2) Embolization (coiling), 3) VP shunt (if hydrocephalus develops), 4) Seizure prophylaxis with phenytoin
ASA infarction presentation?
Loss of all function except for the posterior column (position and vibration sensation)
Subacute combined degeneration presentation?
Loss of position and vibratory sensation (ataxic gait, paresthesia, impaired position and vibration sense)
Presentation and Treatment of spinal trauma?
Loss of reflex and motor function, hypotension. IVGlucocorticoids
Brown sequard presentation?
Pain and temp on contralateral side from injury 2 levels below and position and vibratory sense lost on ipsilateral side of injury
Best tx syringomyelia?
Surgical removal of tumor if present and drainage of fluid from cavity.
Best initial/most accurate brain abscess?
CT/MRI initial and biopsy accurate
Empiric tx brain abscess?
Penicillin + metro + ceftriaxone
Tuberous sclerosis symp?
HAMARTOMAS-Hamartomas, Ash leaf, mit regurg, angiofibroma, rhabdomyosarcoma (cardiac), tuberous sclerosis, auto dOm, mental redard, renal Angiomyolipoma, Seizure, shahgreen
Best diagnosis of NF2 acoustic schwannomas
MRI w/ gadolinium
NF1 presentation
Cafe au lait, neurofibromas (cutaneous), optic gliomas, lisch nodules (iris hamartomas),
NF2 presentation
Bilateral acoustic schwannomas, meningioma, juvenile cataracts, ependymomas
Sturge Weber presentation?
STURGE (Seizures/Stain, Tram track opposing gyri, Unilateral, Retardation, Glaucoma, Epilepsy)
Tx essential tremor?
1) propranolol 2) anticonvulsant (primodine/topiramate)
Parkinsons symptoms?
TRAPS (Tremor, Rigidity, Akinesia/brady, Postural instability (orthostatic hypotension), Shuffling gait)
What is shy drager (multiple system atrophy)?
Parkinsonism, autonomi dysfunction (cholinergic), widespread neurologic signs (cerebrellar) tx. volume expansion with hydrocortisone
Mild disease parkinsons tx >60 or
> 60: amantadine (increases dopamine release from snpc) and
Severe disease w/ inability to care and orthostasis parkinson best initial/most effective therapy
Best initial: dopamine agonists (pramipexole, ropinirole) used with COMT inhibitor (tolcapone/entacopone) to reduce “on/off” phenomenon
Most effective: Levodopa/carbidopa
Best tx to prevent progression parkinson?
MAO inhibitor (rasagiline, selegiline)
Tx of spasticity (painful muscle contractions)?
Baclofen, dantrolene, and tizanadine (alpha agonist)
Tx RLS?
Mild/intermittent: Iron with
Symptom triad and tx in huntington?
Memory (dementia), Mood (psychosis w/haloperidol or quetiapine), Movement (dyskinesia tx with tetrabenazine)
Tourette tx?
Fluphenazine, pimozide, clonazepam (Cloning pimp on tour w/ flu). Methyphenidade and ADHD intrinsic to Tourette
LP for MS?
Increase protein, 50-100 WBC, increase IgG, oligoclonal bands
Tx for acute episode vs preventing relapse MS?
Acute-high dose steroids, plasmapharesis (if steroids not effective)
Relapse-B-interferon or Glatiramer
Patient hs worsening neurological defecits with use of chronic suppressive medication for MS with new mutiple white matter lesions. What caused it?
Natalizumab-alpha 4 integrin inhibitor also associated with PML
Diagnostic test/tx ALS?
Test-EMG and CPK (secondary to muscle wasting). Riluzole decreases glutamate buildup in neurons and baclofen treats spasticity. CPAP and BiPAP help with resp difficulties
Characteristics and Most accurate test charcot marie tooth?
Inverted champagne bottle legs, high arch (pes cavus), and motor and sensory loss. EMG
Tx. peripheral neuropathy?
Pregablin/gabapentin, TCA
Lateral cutaneous nerve percipitating event and presentation?
Obesity, pregnancy, and sitting with crossed legs. Pain/numbness of outer aspect of one thigh
Peroneal neruopathy pericpitating even and presentation?
High boots and pressure on back of knee. Weak foot with decreased dorsiflexion and eversion (footdrop)