Nutrition Module 8: Micronutrients Review Flashcards
What are the 4 lipid soluble vitamins?
ADEK
What is needed to digest lipid soluble vitamins?
Micelles
Out of the 4 lipid soluble vitamins, which one is poorly stored in the body?
Vitamin K: only last a few days
What can limit the absorption of lipid soluble vitamins?
Meal w/o fat
Vitamin A: sources? 6
- Sweet potatoes
- Carrots
- Green leafy veggies
- Eggs
- cheese
- Milk
Vitamin A: functions? 3
- Vision
- Immune function
- Growth
Vitamin A: deficiency? Common for who? 7
- Visual impairment and other occular symptoms
- Loss of appetite
- Susceptibility to infections
- Chronic skin xerosis
- Follicular hyperkeratosis with no bleeding
- Bitot’s spots
- Night blindness
Extremely common in children in underdeveloped countries
Vitamin A: toxicity? 4 + 1
RETINOL ONLY
- Liver and bone damage
- Vomiting
- Dry mucous membranes
- Headaches
+ Mutagenic potential of retinol during early pregnancy
Vitamin D: sources? 3
- Fortified milk/formula
- Fish
- Eggs
*Produced in sun-exposed skin
Vitamin D: functions? 4
- Growth regulation
- Immune function
- Calcium/Phosphorus absorption
- Bone health
Vitamin D: deficiency? Common for who? 11
- Rickets,
- Osteomalacia (softening of the bones)
- Osteoporosis
- Lax muscles
- Risk of falls
- Diminished calcium absorption and retention
- Cancer
- Bowed legs
- Epiphyseal enlargement of the wrists
- Craniotabes
- Thorax deformities
Vitamin D: toxicity? 2
- Brain damage in young infants
2. Calcification of arteries and other soft tissues
Vitamin E: sources? 3
- Vegetable oils
- Nuts and seeds
- Margarine
What is the natural form of Vitamin E? Bioavailability?
RRR-a-tocopherol: highly available
What does synthetic Vitamin E contain? Which ones ate bioavailable?
Equal amounts of 8 stereoisomers; only half (the 2-S forms) are highly bioavailable
Vitamin E: functions? 1
- Antioxidant in lipid-rich components
Vitamin E: deficiency? 2
- Peripheral neuropathy
2. Hemolysis
Vitamin E: toxicity? 2
- Bleeding
2. Hemorrhagic stroke
Vitamin K: sources? 4
- Cooked greens
- Green vegetables
- Canola and soybean oil
- Intestinal bacteria
Vitamin K: functions? 2
- Blood coagulation
2. Protein synthesis involved in mineralization (eg: involved in calcification inhibition)
Vitamin K: deficiency? 2
- Prolonged bleeding time/episodes
2. Purpura
Vitamin K: toxicity? 1
- Interferes with anticoagulant meds
What are fortified foods?
Foods with added nutrients
Are water soluble vitamins stored extensively?
NOPE except for B12
After how long can you tell you have a water soluble vitamin deficiency?
Few weeks
Vitamin C: sources? 2
- Fruits
2. Veggies
Vitamin C: functions? 5
- AA metabolism
- Bone/Teeth formation
- Collagen formation through proline and lysine hydroxylation
- Antioxidant for cell membranes
- Vitamin E regeneration
Vitamin C: deficiency? 11
SCURVY:
- Poor wound healing
- Bleeding of gums
- Perifollicular petechiae (broken capillaries)
- Cork-screw body hair
- Fatigue
- Pain
- Death
- Weakness, joint pain
- Subperiosteal bleeding
- Follicular hyperkeratosis with petechiae
- Splinter hemorrhages (nail bed)
Vitamin C: toxicity? 3
- Osmotic diarrhea
- Gastrointestinal disease
- Kidney stones (oxalate)
What are the 9 non-specific symptoms of folate deficiency?
- Loss of appetite
- Irritability*
- Hostility
- Diarrhea*
- Paranoia
- Forgetfulness
- Depression*
- Macrocytic anemia*
- Increased homocysteine blood concentration
What is the risk of folate deficiency in adults?
Cancer and CVD
What do polyglutamate folate serve as? Which kind?
Coenzyme that accept or donate 1 C units in :
- . Catabolism or interconversion of Met, His, Ser, and Gly (esp. homocysteine to cysteine)
- Choline synthesis and degradation
- Serotonin and epi synthesis
+ DNA SYNTHESIS
Fully reduced tetrahydrofolate
What are 8 good food sources of folate?
- Fresh dark leafy veggies
- Legumes
- Cereal
- Citrus fruits
- Organ meats
- Yeast
- Fortified grains
- Flour-based foods
Folate: toxicity? 2
- Masks B12 deficiency
2. Risk of tumors when taking supplements
What are the 9 water soluble vitamins?
- Vitamin C
- Folate
- Thiamin
- Riboflavin (B2)
- Niacin (B3)
- Pyridoxine (B6)
- Cobalamin (B12)
- Pantothenate
- Biotin
Thiamin: sources? 4
- Pork
- Meat substitutes
- Green peas
- Enriched grains
Thiamin: functions? 3
- Cofactor for alphaketoglutarate dehydrogenase, pyruvate dehydrogenase, etc.
- Neuron function
Thiamin: deficiency? 3
2 at risk peeps?
- Dry Beri Beri
- Wet Beri Beri
- Muscle weakness
- Alcoholics
- Hyperemesis gravidarum (pregnancy complication)
What are the symptoms of Dry Beri Beri? 4
- Neuropathy
- Confusion
- Confabulation
- Demention
What are the symptoms of Wet Beri Beri? 2
- Heart failure
2. Edema
Thiamin: toxicity? 1
None
Riboflavin: sources? 3
- Milk
- Eggs
- Broccoli
Where is riboflavin absorbed?
Proximal small intestine
Which vitamin has a saturable transport uptake mechanism?
Riboflavin
How is riboflavin excreted?
Urine
Where is riboflavin stored? 3
- Liver
- Kidney
- Muscle
Riboflavin: functions? 1
- Catalyzes redox rxns
Riboflavin: deficiency? 9
- Edema
- Dermatitis
- Angular stomatitis (inflammation of mouth mucosa)
- Anemia
- Niacin deficiency
- B6 deficiency
- Impairs folate function
- Nasolabial seborrhea
- Angular cheilosis and stomatitis
What can riboflavin deficiency result from? 3
- Cancer
- Diabetes
- CVD
Riboflavin: toxicity? 1
None
Niacin: sources? 4
- Fortified dry cereal
- Beef
- Eggs
- Milk
Niacin: functions? 2
- Fuel metabolism
2. Synthesis/removal of many compounds
What is pellagra? 6 symptoms
Common in what peeps?
Deficiency of tryptophan and niacin:
- Weight loss
- Diarrhea
- Dermatitis
- Depression
- Dementia
- Death
- Scarlet-colored tongue
- Hyperpigmented skin
Alcoholics
Niacin: toxicity? 5
- Flushing
- GI things
- Liver dysfunction
- Glucose intolerance
- Ocular effects
Pyridoxine: sources? 6
- Meat
- Poultry
- Fish
- Corn
- Bananes
- Potatoes (sweet and normal)
Pyridoxine: functions? 2
- Transamination of AAs
2. Cofactor for many enzymes
Pyridoxine: deficiency? 8
- Slow growth
- Cerebral/Peripheral neuron damage
- Confusion
- Cheilosis (dry edges of mouth)
- Depression
- Microcytic anemia
- Glossitis (tongue soreness)
- Sideroblastic anemia, anisocytosis
Pyridoxine: toxicity? 1
- Sensory neuropathy
Cobalamin: sources? 4
- Meat
- Poultry
- Dairy
- Eggs
Only foods of animal origin
Cobalamin: functions? 3
- Cofactor for methionine synthase and L-methylmalonyl CoA
2. Conversion of homocysteine to methionine
Pantothenate: deficiency? 6
- Fatigue
- Depression
- Anemia
- Loss of hair color
- Infertility
- Impaired immune response
Cobalamin: deficiency? 4
SAME AS FOLATE +
- Neuropathy
- Depression
- Confusion
- Dementia
Cobalamin: toxicity? 1
None
Pantothenate: sources? 4
- Sweet potatoes
- Legumes
- Yogurt
- Chicken
What are the 3 precursors for the synthesis of CoA?
- Pantothenate
- Cysteine
- ATP
Pantothenate: functions? 1
- Acyl carrier protein in fatty acid synthase
What are the 6 functions of CoA?
- Fuel metabolism
- Protein modification
- Synthesis of fatty acids
- Phospholipids synthesis
- Cholesterol synthesis
- Steroid hormones
Pantothenate: toxicity? 1
None
Biotin: sources? 5
- Intestinal flora
- Cauliflower
- Soybeans
- Eggs
- Mushrooms
Biotin: function? 1
Coenzyme for carboxylases
Biotinidase function? 1
Absorption and recycling of protein-bound biotin
In what people is biotin deficiency seen?
People with biotinidase defect
Biotin: toxicity? 1
None
Where is pyridoxine stored?
Muscles
Overall, what are water soluble vitamins used for?
Cofactors for fuel metabolism
Are mineral/trace elements stored extensively?
YES (weeks storage)
Where are mineral/trace elements stored?
- Bone
2. Metalloproteins