Lecture 28: Diabetes Flashcards
How many grams of FFAs in the body?
12,000
How many grams of glucose in the body? How much is circulating?
80
20 grams circulating = 80 kcal
What % of the body’s total energy requirement does the brain consume? How many grams a day is that in the resting state?
25% = 120 g/day
What is the needed blood glucose level for the brain to maintain its normal function?
70 mg/dL
What is the blood glucose limit for danger for the brain?
50 mg/dL
What 3 types of cells are insensitive to insulin?
- Brain
- RBCs/WBCs
- Renal medulla
Why do patients with sepsis often exhibit hypoglycemia?
Increase in WBCs which can only use glucose for energy
What is the renal medulla?
A deep part of the kidney which is not exposed to a lot of O2 so cannot oxidize FAs so only uses anaerobic glucose metabolism
Why is lactic acidosis often seen in extremely ill patients?
Because they rely on anaerobic glycolysis to get energy fast and produces a ton of lactate
What 4 types of cells are sensitive to insulin?
- Liver
- Muscle
- Adipocytes
- Heart
Grams of glycogen stored in muscleS?
400 g
Grams of glycogen stored in liver?
100 g
Grams of fat stores?
12,000
Grams of protein stores?
6,000
For how long after eating is exogenous glucose the main source of fuel?
4 hours
For how long after eating is glycogen the main source of fuel?
4-16 hours
For how long after eating is gluconeogenesis the main source of fuel?
16 hrs-40 days
What does the drop in gluconeogenesis after day 2 of fasting due to?
Ketogenesis helping out
Diabetes incidence?
1 in 3
How many people in the US have DM?
29.1 million
How many people in the US have pre-diabetes?
86 million
Range of normal FBG?
60-100
Range of impaired FBG?
101-125
Range of diabetes FBG?
Above 126