Nutrition and Chronic Diseases Lecture Flashcards
Chronic non-communicable diseases
slow developing, long-lasting diseases that are not contagious. They can be treated but not always cured.
BMI ratings
<18.5 at risk
18.5-24.9 healthy
25-29.9 overweight
>30 obesity
Obese ind have an increased risk for 11 chronic diseases
cardiovascular diabetes type 2 diabetes hypertension (>130) stroke osteoarthritis heart attack cancer - liver, breast, colorectal, endometrial, gallbladder pulmonary disease erectile dysfunction and gynecological abnormalities sleep apnea ability to get pregnant decreases
How does metabolic disease precipitate liver cancer
non-alcoholic fatty liver disease identical to alcoholic. Scar tissue begins to form when the liver is in an inflammatory state - otherwise benign - risk factor for development of liver failure and cancer
Adipose -Based Chronic Disease
New theory proposed - less stigmatization and classifying ind as obese
metabolic syndrome 2
associated with risk of developing cardiovascular disease and type 2 diabetes
pre cursore to diabetes and development of cardiovascular disease - prediabetic, lifestyle habits can be changed to prevent attaining these chronic diseases
How physicians diagnose metabolic syndrome
3/5 of the following
increased waist circumference
- male cut off = 40 inches (102cm)
- female cut off = 35 inches (88cm)
High BP = >130/85mmHg - systolic more important
impaired fasting glucose >5.6mmol after 8 hours of fasting (in the morning) - hyperglycemic
lipid parameters
- HDL - whether the individual is below the threshold for healthy cholesterol - <1.0mmol HDL males; <1.3 mmol HDL females
increase in triacylglycerol in the blood (>1.7mmol/L)
US age 40-69 in 1890 vs 2000
1890 - 3/4% obesity across
2000 - 25-40% of obesity moves up from 40-69
obesity trends among Canadians in 1985, 1998, and 2011
increased substantially
1985 <10%
1998 >15% in Canada except bc and Quebec
2011 25-29% most provinces more in territories 2/3 population, BMI>25, 1/4 population obese
Leading cause of death 2+@
CVD and cancer, diabetes, cerebrovascular
What does high BMI correlate with? (2)
Higher relative risk of CVD, diabetes
What province has the lowest BMI?
BC
Does obesity happen in developing cuntries?
Yes - malnourished and overnourished
Abdominal obesity in Canadian adults and children
doubled and 3 - fold
What is responsible for the increase in obesity in children?
intergenerational obesity
intergenerational risk - women that is pregnant and gains more weight than what is recommended during pregnancy, child will have an increased risk of being obeses later in life due to epigenetic factors on the developing child - blamed used to be female only but males also count
type 2 diabetes and death
80% of people dont but they make you predisposed to CV diseases like heart attacks and stroke
Association between BMI and type 2
strong - pos relationship
How has diet changed? (6)
Increased processed foods total dietary fats has decreased from 40-30% increased meat consumption increased refined carbs decrease in dietary fibre increased kcals/day -240
risk factors
a condition or behaviour associated with an increased frequency of a disease but not proved to be causal - persist over time, cluster
How many lbs of sugar does the avg Canadian consume/year
151lbs - high fructose corn syrup has increased
sugar industry and coronary heart disease research
From harvard was anti-fat pushing the idea tht ind should be consuming more sugar and carbs
fructose is cleared by
liver via portal vein
storage of glucose
glycogen but rate limiting by ATP citrate - prevents glucose from entering the mitochondria - instead of glycogen turns into fructose then acetyl co-A then fatty acids
lipogenesis
FA in mitochondria increased by fructose