Detox Flashcards
detox
short term intervention designed to eliminate toxins from the body, promote health and assist with weight loss and reset your physiology
detox diets
total starvation to juicing to food modification, often use laxatives, diuretics, vitamins, herbs, minerals and/or cleansing foods
how many naturopathics use detox
92% and 75% fwith diet detox
most common reason for detox - 8
environmental exposure to toxins, general cleansing/preventative med, GI disorders, autoimmune disease, inflammation, fibromyalgia, chronic fatigue syndrome, weight loss
do we have toxins
nah
commercialized toxins - 5
pollutants synthetic chemicals heavy metals processed foods potentially harmful products from modern life
why is it hard to investigate commercial claims?
they dont identify the specific toxin or how they will eliminate it
quantitative measures of detox studies
none
detox diets can be good for
health promotion and weight loss
what can be toxic in the body
high doses of synthetic chemicals
POP - 5
persistent organic pollutants - industrial chemicals that accumulate in human adipose tissue - flame retardants, pesticides, paints, coolants, lubricants - polybrominated biphenyls
banned by EU, USA and Australia since 70s
linked with endocrine disruption, CV diseases, neurological and developmental defects, metabolic diseases and cancer
animal models and wild life
reduced age of menarche
Phthalate - 5
cosmetics, food packaging, plastic toys, capsule of supplements
reproductive and developmental problems in in animals
androgenic effect in humans
not covalently bonded - released upon heating
KD- decrease exposure to pregnant and kids
Bisphenol A (BPA) - 4
plastic food and drink packaging
reproductive changes, CV disease and diabetes
current exposure not considered a significant health risk
estrogen mimicking
moulds
volatile metabolites - adverse health effects
iodine
found naturally in body can lead to thyroid disorder when consumed in excess
metals - 5
toxic to humans
mercury, lead (brain), cadmium(renal), arsenic (few types of cancer, high conc in rice, cook it like pasta), aluminum (reduced bone mineral density, regulation of enzymes)
arsenic levels are problematic where?
bangladesh - conc in groundwater is high
way of detox - 4
depends on chemical - include conversion to a less toxic form
methylation of arsenic to reduce toxicity
metabolism or conjugation to produce water soluble for renal excretion
conjugation with glutathione for GI elimination as bile
intracellular metallothionein binding of heavy metals
mercury half life in blood
57 days - too much will affect the NS
lead half life in bones
20-30 yrs
Consideration for detox diets - 2
energy restriction - weight loss - redistribute POPs from fat stores into circulation
obese ind after bariatic surgery, 15 week weight loss program
half lives of BPA and phthalate
short half lives >12h but consistently present in human bodies - water bottles, food containers, linings of food and beverage cans
in how many people will BPA be detected?
urine of >90% of US - difficult to avoid plastic contamination
success rate of diets and why
20% - evolved mechanism to defend against weight loss because starvation can lead to reduced fertility and even death