Nutrition Flashcards
Fat soluble vitamins?
Vitamins A, D, E, K
-Come in gelatin tablet with oil in center
Vitamin A
Retinol
Vitamin E
Tocopherol
“Toke-of-ethanol”
Vitamin K
Phylloquinone
-“File-o-kanines”
File cabinet of dogs shaped like K
Vitamin B1
Thiamine
Vitamin B2
Riboflavin
Vitamin B3
Niacin
Vitamin B5
Pantothenic acid
Pentothenic acid
Vitamin B6
Pyridoxine
Pyrido6ine
Vitamin B9
Folate
Fool comes late it is benign
Vitamin B12
Cyanocobalamin
Weird B vitamin?
Biotin
Ascorbic Acid
Vitamin C
Most common cause of blindness in young children?
Vitamin A deficiency
Retinol is very similar to retina
Xerophthalmia (dry eyes), nyctalopia (night blindness), complete blindness
Vitamin A deficiency
What can cause intracranial hypertension (pseudotumor cerebri)?
Vitamin A intoxication
-Giant A causing intracranial pressure
Large tongue and macrocytic anemia?
Vitamin B9 (folate) deficiency
What can vitamin B9 (folate) toxicity cause?
Irritability
If you give folate (B9) for macrocytic anemia, what can it mask?
B12 Deficiency
B12 deficiency?
Macrocytic anemia
-Bowel disease can lead to pernicious anemia due to poor B12 absorption secondary to decreased intrinsic factor
Can B12 in excess be toxic?
No
Bleeding gums, scurvy, leg tenderness, poor wound healing
Vitamin C deficiency
What can excessive mega doses of vitamin C cause?
Oxalate and cysteine nephrocalcinosis
Excreted through kidneys
What vitamin can trigger a hemolytic crisis in someone with G6PD deficiency?
Vitamin C
Hemolytic anemia in preemies and neurological effects in older kids
Vitamin E deficiency
Has to be a severely prolonged deficiency
-E is a fork puncturing red cells
Neuropathies, peripheral edema, thrombocytosis, muscle weakness
Vitamin E deficiency
Vitamin E toxicity?
Liver toxicity
Hemorrhagic disease of the newborn
Vitamin K deficiency
What vitamin doesn’t cross the placenta well?
Vitamin K
Why can’t a newborn produce vitamin K well?
Gut flora hasn’t been established
Vitamin K dependent factors are only what % of normal in first 2-3 days of life?
30%
Are breast fed or formula fed babies babies more vulnerable to vitamin K deficiency?
Breast fed- Breast milk doesn’t contain much vitamin K
Child born at home (did not get vitamin K at birth), exclusively breast fed, bleeding
Give vitamin K followed by FFP
K to make factors 10, 9, 7, 2
FFP for instant clotting factors (active bleeding)
What are the vitamin K dependent factors?
2, 7, 9, 10
Edema, erythrocyte explosion (hemolytic anemia), elevated platelet count
Triple E of vitamin E deficiency
What is isotretinoin an analog of?
Vitamin A
What is isotretinoin used to treat?
Acne
Which drug used for teens is a significant teratogen?
Isotretinoin
HAVE TO RULE OUT PREGANCY
Teen with symptoms of a brain tumor who takes isotretinoin
Vitamin A toxicity (pseudotumor cerebri)
Yellow toddler who eats lots of beta-carotene (carrots, sweet potatoes, apricots), but sclerae and oral mucosa aren’t yellow
No further evaluation or change diet
NOT jaundice or icteric, don’t get serum bili
What is common finding between B12 and B9 deficiency?
Macrocytic anemia
What is beta carotene converted to in the body?
Vitamin A (retinol)
It’s a precursor to vitamin A
Vitamin D2
Ergocalciferol (2 Cs, D2)
Vitamin D3
Cholecalciferol (3 Cs, D3)
25-Hydroxy Vitamin D
Calcidiol
Where is calcidiol (25-Hydroxy Vitamin D) hydroxylated?
Liver
1,25 Hydroxy Calciferol
1,25-Dihydroxycholecalciferol or calcitriol
-Calcitriol tries to help the body by increasing calcium absorption in the gut and releasing it into the blood from bone
Where is 1,25 Hydroxy-calciferol formed?
Kidney
What is the active metabolite of vitamin D?
1,25 Hydroxy-calciferol
What is the only vitamin known to be converted to hormone form?
Vitamin D
If I child is exposed to sufficient UV sunlight do they need any dietary vitamin D?
No
What is the primary storage form of vitamin D and the one you will measure?
25-Hydroxy Vitamin D
Who do you supplement vitamin D for?
Exclusively breast fed infants (by 2 weeks)
Low vitamin D causes?
Rickets
What electrolyte problems are from vitamin D excess?
Hypercalcemia and hyperphosphatemia
Symptoms of vitamin D excess?
Nausea, vomiting, weakness, polyuria, polydipsia, elevated BUN, nephrolothiasis, renal failure
It can be fatal
Similar symptoms to diabetes (both have D)
How to treat vitamin D toxicity
Hydration, lasix, correct sodium/potassium depletion
-It causes mobilization of calcium and phosphorous from bones and deposition into soft tissue
Calorie requirements
1500kcal for first 20kg, then 20kcal/kg for each additional kg
- 100kcal/kg for first 10kg
- 50kcal/kg for next 10kg
- 20kcal/kg for any more kg
What is caloric intake for children based on?
Body surface area
Which varies child to child
Recommended daily allowance (RDA) is starting point for estimating caloric requirements in kids.
Why can infants still lose weight even if they are receiving adequate nutrition, there are no increases insensible losses, and there is no evidence of renal failure?
Due to renal fluid loss as a result of increased solute load…infants kidneys can’t handle the same osmotic load of an adult during times of stress (relationship with dietary protein and renal solute load)
What are calorie requirements for term/preterm infants?
100-120 kcal/kg/day
-Preemies closer to 120, large term closer to 100
How much protein for premature infants?
3.5 g/kg/day
Protein for full term infants?
2.0-2.5 g/kg/day for first 6 months
Why do premature infants have trouble maintaining appropriate body temperature?
Lower levels of fat storage
-Expend more energy in heat production than term babies
Premature babies require more energy for what 2 things?
Organogenesis and developing fat stores
-This all increases nutritional and energy requirements in comparison to term babies
When does catch up growth in preemies happen?
First 2 years (Should attain normal height at 2 and beyond)
Post-op infant not gaining weight… Cause?
Increased urine output secondary to increased renal solute load (Even is surgery was for big GI procedure like malrotation implying poor absorption or protein losing enteropathy)
What are 4 important components of renal solute load?
-Sodium, potassium, chloride, phosphorus
What electrolyte doesn’t play a major role in renal solute load?
Calcium
If you are choosing an essential fatty acid, which one is it?
Linoleic Acid
No cow milk before…?
12 months
What milk from age 1-2?
Whole milk
Low fat milk when?
Overweight children after age 12 months
Does formula have adequate fluoride?
No, it needs to come from outside sources, like drinking water
What is the recommended concentration of iron in iron fortified formula?
12 mg/L
What can cause iron deficiency anemia in a toddler?
Drinking too much milk
Who needs iron supplementation at birth?
Only those at high risk (LBW or preterm, even if breastfed)
-Full term babies have adequate iron stores
When should all babies (even breast fed infants) get iron supplementation in their food (iron-fortified cereals)?
Start around 4-6 months of age
What blood problem is associated with obesity in children?
Iron deficiency anemia
When do you use low iron formula (1.5 mg/L)?
NEVER
Does iron fortified formula cause constipation?
No
Kid in iron fortified formula has constipation… What do you do?
Add fruit juice to increase osmotic load
-Don’t use low iron formula, dilute the formula, switch to whole milk, or add more cereal
Which is IgE mediated, milk protein allergy or milk intolerance?
Milk protein allergy
Which two formula intolerance can cause rash, vomiting, and irritability?
Milk protein allergy and milk intolerance
Due to IgE mediated response, presents with rash, vomiting, and irritability
Milk protein allergy
What formula intolerance causes irritability, but no rash or vomiting?
Lactose intolerance
When can a secondary lactase deficiency causing lactose intolerance in kids develop?
After GI infection (like rotavirus)
With true milk allergy what is there significant cross reactivity with?
Soy-based formula, use elemental formula
Infant with bloating and worsening diarrhea after formula is reintroduced into diet following episode of viral gastroenteritis?
Lactose intolerance due to secondary lactase deficiency (usually doesn’t happen, but it can)
-You can hold off on lactose-containing formula in young infant until diarrhea resolves, but DONT hold hold off on breastfeeding
Vomiting, rash, diarrhea, irritability
Milk protein allergy/intolerance
Flatulence, bloating, diarrhea, irritability
Lactose intolerance
Where are 3 places lactose is found?
Human milk, cow based formula, evaporated cow milk
Infants fed “non-traditional” formula will suffer from what?
Nutritional deficiencies
Who do you give protein hydrolysate formula to?
Infants with allergy to intact milk protein or allergy or soy protein
Non IgE mediated severe cow milk protein intolerance
FPIES: Food protein induced enterocolitis syndrome
How does FPIES present?
In first 3 months with either heme positive stools or hematochezia along with normal abdominal exam
Can FPIES affect breast fed infants?
Yes, cow milk protein ingested by mom can get into breast milk, (this is primarily due to cow milk intolerance)
What do you do for a kid with FPIES?
Switch to protein hydrolysate formula or completely eliminate implicated protein from Moms diet
Do not switch to soy formula (symptoms frequently continue with this)
Scaly dermatitis, alopecia, thrombocytopenia
Essential fatty acid deficiency
-Thin fish with scales coming off (scaly rash), that turn into platelets (low platelet count), fish is bald (alopecia)
Treatment for essential fatty acid deficiency
IV lipids (focus on linoleic acid)
Mineral deficiency presenting with dermatitis and alopecia?
Acrodermatitis enteropathica (Inherited condition where zinc isn’t absorbed well)
Infant with dermatitis and alopecia who was recently weaned from breast milk…
Zinc deficiency
Breast milk contains a protein which facilitates zinc absorption
Typical presentation of zinc deficiency?
Infant with extensive eczematous eruption, growing poorly, lesions around mouth, sometimes in perianal area
What is inheritance of acrodermatitis enteropathica?
AR
What differentiates eczema from acrodermatitis enteropathica?
Acrodermatitis enteropathica has no lichenification
Low serum copper, low serum ceruloplasmin, high tissue copper, twisted hairs (pili torti)
Menkes kinky hair syndrome
Inheritance of menkes kinky hair syndrome
X-linked
“Liver deterioration” ( jaundice, large liver), acute neurological deterioration, Kayser Fletcher rings, low ceruloplasmin
Wilson’s disease