Nucleotide Metab Purines Flashcards
1
Q
Degradation of RNA or DNA & intermediates of purine synthesis
A
Salvage pathway
2
Q
Tissues/organs capable of salvage pathway only
A
Brain & bone marrow
3
Q
Transferases involved in Salvage pathway
A
– APRT (adenine phosphoribosyl transferase) for adenine.
– HGPRT (hypoxanthine guanine phosphoribosyl transferase) for guanine or hypoxanthine.
4
Q
Purine bases created by degradation of RNA or DNA and intermediate of purine synthesis can be directly converted to the corresponding nucleotides.
A
Salvage pathway
5
Q
Absence of activity of ________ leads to Lesch-Nyhan syndrome.
A
HGPRT
6
Q
C6 is from
A
CO2
7
Q
N1 is from
A
Aspartate
8
Q
C4, C5, N7
A
Glycine
9
Q
C2, C8
A
Tetrahydrofolate
10
Q
N3, N9
A
Amide N of glutamine
11
Q
Enzyme that adds phosphate group
A
Kinase
